Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Toyofumi Yamaguchi"'
Publikováno v:
Microbiology and Immunology. 61:398-402
An anti-varicella-zoster virus compound, a 5-chlorobenzo[b]thiophen derivative (45B5), was characterized. Its 50% effective concentration against the cell-free vaccine Oka strain and 50% cytotoxic concentration in human fibroblasts were 16.9 µM and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be3e3ece26b9ade292207d5413450b7c
https://doi.org/10.1111/1348-0421.12507
https://doi.org/10.1111/1348-0421.12507
Publikováno v:
Antiviral Chemistry & Chemotherapy, Vol 26 (2018)
Antiviral Chemistry & Chemotherapy
Antiviral Chemistry & Chemotherapy
Background Previously, we established a reporter cell line for human cytomegalovirus and screened anti-human cytomegalovirus compounds using the cell line. In this study, we characterized one of the identified compounds, 2,4-diamino-6–(4-methoxyphe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0dd45d46cb1a6bbe7776cd73bfd9232
https://doaj.org/article/347948cd52444f4db0b10d5605677677
https://doaj.org/article/347948cd52444f4db0b10d5605677677
Publikováno v:
Microbiology and immunology. 61(9)
An anti-varicella-zoster virus compound, a 5-chlorobenzo[b]thiophen derivative (45B5), was characterized. Its 50% effective concentration against the cell-free vaccine Oka strain and 50% cytotoxic concentration in human fibroblasts were 16.9 µM and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::68d507ae3b10d9d5e2b00590619e0894
https://pubmed.ncbi.nlm.nih.gov/28833387
https://pubmed.ncbi.nlm.nih.gov/28833387
Autor:
Toyofumi Yamaguchi, Kaede Hashimoto, Minami Kato, Saki Fukuchi, Souichi Yamada, Harutaka Katano, Naoki Inoue, Kohji Moriishi, Yuko Sato
Publikováno v:
Vaccine. 31:3199-3205
Background Cytomegalovirus (CMV) is the most common cause of congenital virus infection. Infection of guinea pigs with guinea pig CMV (GPCMV) can provide a useful model for the analysis of its pathogenesis as well as for the evaluation of vaccines. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be6e4678bf8bc836cccc3382258f186
https://doi.org/10.1016/j.vaccine.2013.04.078
https://doi.org/10.1016/j.vaccine.2013.04.078
Publikováno v:
Antiviral research. 140
Previously we established reporter cell lines for human cytomegalovirus (HCMV) and varicella zoster virus (VZV) and identified several antiviral compounds against these viruses using the reporter cells. In this study, we found that one of the identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27cd9772de3e1578cbb259a0adabeafa
https://pubmed.ncbi.nlm.nih.gov/28161581
https://pubmed.ncbi.nlm.nih.gov/28161581
Autor:
Hazuki Takahashi, Mineo Saneyoshi, Xiaohong Liu, Yoko Harada, Yoshiyuku Mizushina, Yuta Ogimura, Toyofumi Yamaguchi, Tsukasa Ogawara
Publikováno v:
Nucleic Acids Research
Telomerase adds telomeric DNA repeats to the ends of linear chromosomal DNA. 3'-Azido-3'-deoxythymidine 5'-triphosphate (AZTTP) is a known telomerase inhibitor. To obtain more selective and potent inhibitors that can be employed as tools for studying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530b7a58564aa02f4befed447cd0b9ef
https://doi.org/10.1093/nar/gkm859
https://doi.org/10.1093/nar/gkm859
Autor:
Chikako Murakami, Kenji Mori, Masahiko Oshige, Osamu Koiwai, Toyofumi Yamaguchi, Mineo Saneyoshi, Noriko Shimazaki, Hiromi Yoshida, Yoshiyuki Mizushina, Kengo Sakaguchi, Nobuyuki Kasai, Hirosato Takikawa, Fumio Sugawara, Xianai Xu
Publikováno v:
Journal of Biochemistry. 133:541-552
Hippospongic acid A (HA-A) is a novel natural triterpene metabolite that exhibits inhibitory activity against the gastrulation of starfish embryos isolated from a marine sponge, Hippospongia sp. We succeeded in chemically synthesizing the natural ena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a427af710dd27d8478b65808a5c6edf
https://doi.org/10.1093/jb/mvg070
https://doi.org/10.1093/jb/mvg070
Autor:
Rieko Yamada, Mineo Saneyoshi, Motoki Saito, Aki Tomikawa, Toyofumi Yamaguchi, Fuyuki Ishikawa, Koichi Shudo
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 20:1243-1246
In order to clarify whether L-enantiomers of natural 2'-deoxyribonucleoside 5'-triphosphates (dNTPs) are recognized by human telomerase, a quantitative telomerase assay based on the 'stretch PCR' method was developed and used for kinetic analysis. Am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4988f17b3c37b6868358bf83074c77ed
https://doi.org/10.1081/ncn-100002527
https://doi.org/10.1081/ncn-100002527
Autor:
Takayasu Date, Mineo Saneyoshi, Toyofumi Yamaguchi, Fumio Sugawara, Kengo Sakaguchi, Yoshiyuki Mizushina, Tadayasu Ohkubo
Publikováno v:
Journal of Biological Chemistry. 274:25599-25607
We reported previously that long-chain fatty acids are potent inhibitors of mammalian DNA polymerase beta. At present, based on information available from the NMR structure of the N-terminal 8-kDa domain, we examined the structural interaction with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85e0dba7c2f926a1d5a3a90b850bef85
https://doi.org/10.1074/jbc.274.36.25599
https://doi.org/10.1074/jbc.274.36.25599
Autor:
Kengo Sakaguchi, Linda Hanashima, Fumio Sugawara, Shonen Yoshida, Akio Matsukage, Mineo Saneyoshi, Toyofumi Yamaguchi, Masaharu Takemura, Yoshiyuki Mizushina
Publikováno v:
Biochemical and Biophysical Research Communications. 249:17-22
We found and isolated two natural products in the extract from a basidiomycete, Ganoderma lucidum, as eukaryotic DNA polymerase inhibitors. The compounds were identified as cerebrosides, (4E,8E)-N-D-2'-hydroxypalmitoyl- 1-O-beta-D-glucopyranosyl-9-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363a9fc9fa5c14ba5eb3a3ef16736f01
https://doi.org/10.1006/bbrc.1998.9091
https://doi.org/10.1006/bbrc.1998.9091