Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Toya Ohashi"'
Autor:
Toshiki Tsunogai, Toya Ohashi, Yohta Shimada, Takashi Higuchi, Ayaka Kimura, Ayako M. Watabe, Fusao Kato, Hiroyuki Ida, Hiroshi Kobayashi
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 448-460 (2022)
GM1-gangliosidosis is a progressive neurodegenerative glycosphingolipidosis resulting from a GLB1 gene mutation causing a deficiency of the lysosomal enzyme β-galactosidase, which leads to the abnormal accumulation of GM1 ganglioside in the central
Externí odkaz:
https://doaj.org/article/7324db0761c5449a83b52405a909083c
Autor:
Ikuko Anan, Toru Sakuma, Eiko Fukuro, Satoshi Morimoto, Ayumi Nojiri, Makoto Kawai, Ken Sakurai, Masahisa Kobayashi, Hiroshi Kobayashi, Hiroyuki Ida, Toya Ohashi, Michihiro Yoshimura, Yoshikatsu Eto, Kenichi Hongo
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 31, Iss , Pp 100858- (2022)
Aims: T1 mapping in cardiac magnetic resonance imaging enables us to distinguish various myocardial diseases showing left ventricular hypertrophy. Fabry disease is a lysosomal storage disorder causing the accumulation of glycosphingolipids into vario
Externí odkaz:
https://doaj.org/article/123629e70f1948b28f4633d9f2a25793
Autor:
Miho Wada, Yohta Shimada, Sayoko Iizuka, Natsumi Ishii, Hiromi Hiraki, Toshiaki Tachibana, Kazuhiro Maeda, Mitsuru Saito, Shoutaro Arakawa, Takuya Ishimoto, Takayoshi Nakano, Hiroyuki Ida, Toya Ohashi, Hiroshi Kobayashi
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 261-274 (2020)
Mucopolysaccharidosis type II is a disease caused by organ accumulation of glycosaminoglycans due to iduronate 2-sulfatase deficiency. This study investigated the pathophysiology of the bone complications associated with mucopolysaccharidosis II and
Externí odkaz:
https://doaj.org/article/d2d11fb78c1542e5850cea2f318246be
Autor:
Satoshi Morimoto, Ayumi Nojiri, Eiko Fukuro, Ikuko Anan, Makoto Kawai, Ken Sakurai, Masahisa Kobayashi, Hiroshi Kobayashi, Hiroyuki Ida, Toya Ohashi, Takahiro Shibata, Michihiro Yoshimura, Yoshikatsu Eto, Kenichi Hongo
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2021)
Objective: An electrocardiogram (ECG) is an important tool for demonstrating cardiac manifestations in various heart diseases. The present study clarified the characteristics of ECG parameters in Japanese Fabry patients under long-term enzyme replace
Externí odkaz:
https://doaj.org/article/da0c6b32638244dbab3db5b7fe5d67f6
Autor:
Naoki Takada, Hiroshi Sugano, Yoshihiro Shirai, Nobuhiro Saito, Ryoga Hamura, Tomohiko Taniai, Tadashi Uwagawa, Katsuhiko Yanaga, Toru Ikegami, Toya Ohashi, Ken Eto
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257019 (2021)
Nuclear factor kappa B (NF-κB) is a transcriptional factor that can be activated by radiotherapy and chemotherapy. The synthetic protease inhibitor nafamostat mesilate (NM) inhibits NF-κB activity and exerts antitumor actions in various types of ca
Externí odkaz:
https://doaj.org/article/57ecd7a11fee43a397cbac4cb04ddc4f
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 24, Iss , Pp 100623- (2020)
Fabry disease is an X-linked metabolic disorder due to a pathogenic mutation of the GLA gene. The accumulation of globotriaosylceramide (Gb3) damages multiple organs, including the heart, kidney and nervous system, especially in classical type Fabry
Externí odkaz:
https://doaj.org/article/3d092ae8b684436d9f8cb32564ab2224
Autor:
Masahisa Kobayashi, Toya Ohashi, Sayoko Iizuka, Eiko Kaneshiro, Takashi Higuchi, Yoshikatsu Eto, Hiroyuki Ida
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 1, Iss C, Pp 283-287 (2014)
We examined alpha-galactosidase A (GLA) gene mutations in 74 Japanese families with Fabry disease (FD) to determine the frequency of de novo mutations. In 5 of 74 families (6.8%), the probands had no positive family histories and were diagnosed as de
Externí odkaz:
https://doaj.org/article/e26b6b49fe23409bbbe9314dbc294bd5
Autor:
Hiroshi Sugano, Yoshihiro Shirai, Takashi Horiuchi, Nobuhiro Saito, Yohta Shimada, Ken Eto, Tadashi Uwagawa, Toya Ohashi, Katsuhiko Yanaga
Publikováno v:
Cancers, Vol 11, Iss 3, p 335 (2019)
The authors would like to make a correction to their published paper [...]
Externí odkaz:
https://doaj.org/article/cd2158184dbc47ccbee1d9d2aa5842cc
Autor:
Hiroshi Sugano, Yoshihiro Shirai, Takashi Horiuchi, Nobuhiro Saito, Yohta Shimada, Ken Eto, Tadashi Uwagawa, Toya Ohashi, Katsuhiko Yanaga
Publikováno v:
Cancers, Vol 10, Iss 10, p 386 (2018)
Neoadjuvant chemoradiotherapy followed by radical surgery is the standard treatment for patients with locally advanced low rectal cancer. However, several studies have reported that ionizing radiation (IR) activates nuclear factor kappa B (NF-κB) th
Externí odkaz:
https://doaj.org/article/f4178e7d15c5415ea20a53c5188e7367
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Pompe disease (PD) is a lysosomal disorder caused by acid α-glucosidase (GAA) deficiency. Progressive muscular weakness is the major symptom of PD, and enzyme replacement therapy can improve the clinical outcome. However, to achieve a better clinica
Externí odkaz:
https://doaj.org/article/afbdbc9c86034657ad08ae419fbbf912