Výsledky vyhledávání - "Toxine marine"

Role of enteric glial cells in the toxicity of phycotoxins: Investigation with a tri-culture intestinal cell model

Autor: Antoine Huguet, Océane Reale, Valérie Fessard, Dorina Bodi

Publikováno v: Toxicology Letters
Toxicology Letters, Elsevier, 2021, 351, pp.89-98. ⟨10.1016/j.toxlet.2021.08.013⟩

International audience; Lipophilic phycotoxins are secondary metabolites produced by phytoplankton. They can accumulate in edible filtering-shellfish and cause human intoxications, particularly gastrointestinal symptoms. Up to now, the in vitro intes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d389612e7ee2de4301eef0d287efe327
https://hal-anses.archives-ouvertes.fr/anses-03378478

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Differences in Toxic Response Induced by Three Variants of the Diarrheic Shellfish Poisoning Phycotoxins in Human Intestinal Epithelial Caco-2 Cells

Autor: Antoine Huguet, Hélène Quenault, Valérie Fessard, Fanny Rousselet, Olivia Drapeau

Publikováno v: Toxins
Toxins, MDPI, 2020, 12 (12), pp.783. ⟨10.3390/toxins12120783⟩
Volume 12
Issue 12
Toxins, Vol 12, Iss 783, p 783 (2020)

International audience; Diarrheic shellfish poisoning (DSP) is caused by the consumption of shellfish contaminated with a group of phycotoxins that includes okadaic acid (OA), dinophysistoxin-1 (DTX-1), and dinophysistoxin-2 (DTX-2). These toxins are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff23e1744da06c733c311b5ae98b75b
http://europepmc.org/articles/PMC7764622

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Co-culture model of Caco-2/HT29-MTX cells: A promising tool for investigation of phycotoxins toxicity on the intestinal barrier

Autor: Océane Reale, Antoine Huguet, Valérie Fessard

Publikováno v: Chemosphere
Chemosphere, Elsevier, 2021, 273, pp.128497. ⟨10.1016/j.chemosphere.2020.128497⟩

International audience; Most lipophilic phycotoxins have been involved in human intoxications but some of these toxins have never been proven to induce human gastro-intestinal symptoms, although intestinal damage in rodents has been documented. For i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1fc259d501a6f94fbefbda3e0acc1b
https://pubmed.ncbi.nlm.nih.gov/34756374

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Pinnatoxins' Deleterious Effects on Cholinergic Networks: From Experimental Models to Human Health

Autor: Eric Abadie, Jordi Molgó, Jean-Paul Vernoux, Emmeline Lagrange, Marie-Bénédicte Peyrat, Nicolas Delcourt, César Mattei, Valérie Fessard, Nathalie Arnich, Jean-Marc Fremy, Thomas Maignien

Publikováno v: Marine Drugs
Marine drugs
Marine drugs, 2019, 17 (7), pp.425. ⟨10.3390/md17070425⟩
Marine Drugs (1660-3397) (MDPI AG), 2019-07, Vol. 17, N. 7, P. 425 (13p.)
Marine drugs, MDPI, 2019, 17 (7), pp.425. ⟨10.3390/md17070425⟩
Marine Drugs, Vol 17, Iss 7, p 425 (2019)

International audience; Pinnatoxins (PnTXs) are emerging neurotoxins that were discovered about 30 years ago. They are solely produced by the marine dinoflagellate Vulcanodinium rugosum, and may be transferred into the food chain, as they have been f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52aa561965265f1a3f19ff81c3b5a731
https://pubmed.ncbi.nlm.nih.gov/31330850

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Metabolism of the Marine Phycotoxin PTX-2 and Its Effects on Hepatic Xenobiotic Metabolism: Activation of Nuclear Receptors and Modulation of the Phase I Cytochrome P450

Autor: Ludovic Le Hégarat, Dominique Hurtaud-Pessel, Antoine Huguet, Valérie Fessard, Stefanie Hessel-Pras, Alfonso Lampen, Estelle Dubreil, Jimmy Alarcan

Publikováno v: Toxins
Toxins, MDPI, 2017, 9 (7), pp.673-673. ⟨10.1016/j.ab.2006.04.046⟩
Toxins, Vol 9, Iss 7, p 212 (2017)
Toxins; Volume 9; Issue 7; Pages: 212

International audience; PTX-2 is a marine biotoxin frequently found in shellfish that can lead to food intoxication in humans. Information regarding PTX-2 metabolism is scarce, and little is known of its effect on xenobiotic-metabolizing enzymes (XME

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2260844f2933153cb29ede71e33ccf2
https://hal-anses.archives-ouvertes.fr/anses-01570019

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Domoic acid induces direct DNA damage and apoptosis in Caco-2 cells: Recent advances

Autor: William Gerson Matias, Serge Moukha, C. R. Carvalho Pinto-Silva, Edmond E. Creppy

Publikováno v: Environmental Toxicology
Environmental Toxicology, Wiley, 2008, 23 (6), pp.657-663. ⟨10.1002/tox.20361⟩

International audience; Domoic acid (DA) is a neurotoxin produced by sea-water phytoplankton. Shellfish feeding on the phytoplankton can bioconcentrate DA, leading to a potentially serious health hazard for people consuming the contaminated shellfish

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c77ae484fe7fda80c87a451772a5cf
https://doi.org/10.1002/tox.20361

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The cytotoxicity and genotoxicity of okadaic acid are cell-line dependent

Autor: Théophile A. Mobio, Serge Moukha, Edmond Ekoue Creppy, Ghada Souid-Mensi, Khira Maaroufi

Publikováno v: Toxicon
Toxicon, Elsevier, 2008, 51 (8), pp.1338-1344. ⟨10.1016/j.toxicon.2008.03.002⟩

International audience; Okadaic acid (OA) is a polyether fatty acid produced mainly by dinoflagellates causing diarrhoeic shellfish poisoning (DSP) in humans. To resolve the controversies concerning its genotoxicity in vitro, we have investigated eve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3db2a834b3e6e9743b95b5072c3eb3c
https://doi.org/10.1016/j.toxicon.2008.03.002

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Dissertation/ Thesis

Approches synthétiques aux fragments spiroimines du 13-desméthyle spirolide C et de la gymnodimine

Autor: Guthertz, Alexandre

La Gymnodimine et le 13-desméthyle Spirolide C sont des neurotoxines macrocycliques à imine cyclique. Elles ont été isolées dans des organismes filtreurs tels que les moules et les huitres et sont produites par des algues unicellulaires de type

Externí odkaz: http://www.theses.fr/2015BORD0342/document

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Dissertation/ Thesis

Synthèse totale du 13-desméthyle spirolide C

Autor: Rambla, Matt

Les gymnodimines, les spirolides, les pinnatoxines et les ptériatoxines constituent une famille de toxines d’origine marine de structures complexes, produites en faibles quantités par des microorganismes marins appelés dinoflagellés. Ces toxine

Externí odkaz: http://www.theses.fr/2015PA112169/document

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Dissertation/ Thesis

Etudes sur la synthèse du coeur spiroimine de la (–)-gymnodimine A et réaction d'addition asymétrique de silyloxyfuranes sur des accepteurs de Michael cycliques

Autor: Jusseau, Xavier

Externí odkaz: http://www.theses.fr/2013PA112283/document

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