Membrane vesicles from periodontal pathogens and their potential roles in periodontal disease and systemic illnesses

Autor: Li Ma, Zhengguo Cao

Publikováno v: Journal of Periodontal Research. 56:646-655

Periodontium is an ordered ecological system where a dynamic equilibrium exists between oral microorganisms and the host defense system, and periodontal disease occurs whenever the balance is broken. Periodontal pathogens mainly include gram-negative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2612f58a7853e289a04a14d378f486ac
https://doi.org/10.1111/jre.12884

Novel thin-film nanofibrous composite membranes containing directional toxin transport nanochannels for efficient and safe hemodialysis application

Autor: Benjamin S. Hsiao, Yadong Zhu, Xufeng Yu, Xuefen Wang, Tonghui Zhang, Cheng Cheng

Publikováno v: Journal of Membrane Science. 582:151-163

Polymeric hemodialysis (HD) membranes with limited porosities, tortuous pores, and broad pore size distributions suffer from a trade-off between permeability-i.e., how fast toxins pass through the membranes-and selectivity-i.e., to what extent necess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ba86081819a71232c7c6d579df826bb
https://doi.org/10.1016/j.memsci.2019.04.006

Beyond Toxin Transport: Novel Role of ABC Transporter for Enzymatic Machinery of Cereulide NRPS Assembly Line

Autor: Imrich Barák, Genia Lücking, Monika Ehling-Schulz, Michael Sulyok, Agnieszka Gacek-Matthews, Zuzana Chromiková

Publikováno v: mBio, Vol 11, Iss 5 (2020)
mBio

This study revealed a novel, potentially conserved mechanism involved in the biosynthesis of microbial natural products, exemplified by the mitochondrial active depsipeptide cereulide. Similar to other bioactive substances, such as the last-resort an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0abbed4d520ff3b97ab7411a981e0047
https://doi.org/10.1128/mbio.01577-20

Quantitative analysis of receptor-mediated uptake and pro-apoptotic activity of mistletoe lectin-1 by high content imaging

Autor: Beztsinna, N., de Matos, M. B. C., Walther, J., Heyder, C., Hildebrandt, E., Leneweit, G., Mastrobattista, E., Kok, R. J., Afd Pharmaceutics, Pharmaceutics

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports, 8(1). NLM (Medline)
Scientific Reports
Scientific reports, 8, Art. Nr.: 2768

Ribosome inactivating proteins (RIPs) are highly potent cytotoxins that have potential as anticancer therapeutics. Mistletoe lectin 1 (ML1) is a heterodimeric cytotoxic protein isolated from European Mistletoe and belongs to RIP class II. The aim of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25ea283e97b1bc3c6b79fe9bb67e227
https://doaj.org/article/f01b05bd7dc54a97b4639ca51fc7ac36

Toxins Utilize the Endoplasmic Reticulum-Associated Protein Degradation Pathway in Their Intoxication Process

Autor: Monika Słomińska-Wojewódzka, Jowita Nowakowska-Gołacka, Hanna Sominka, Natalia Sowa-Rogozińska

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 6, p 1307 (2019)
International Journal of Molecular Sciences

Several bacterial and plant AB-toxins are delivered by retrograde vesicular transport to the endoplasmic reticulum (ER), where the enzymatically active A subunit is disassembled from the holotoxin and transported to the cytosol. In this process, toxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f9711b03b7887e4897260a14be90a6
http://www.mdpi.com/1422-0067/20/6/1307