Výsledky vyhledávání - "Toxicology and Applied Pharmacology"

The role of annoyance in the relation between transportation noise and children’s health and cognition

Autor: J.H.C.M. Lammers, H.H. Emmen, Mats E. Nilsson, Irene van Kamp, Stephen Stansfeld, Charlotte Clark, Elise van Kempen

Publikováno v: Journal of the Acoustical Society of America, 5, 128, 2817-2828

On the basis of this study it cannot be ruled out that the appraisal of the noise affects the association between air and road traffic noise exposure and children's health and cognition. However, the conclusion is limited due to the relatively small

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bdc9a635c98fe0854ed4fb08942f394
https://doi.org/10.1121/1.3483737

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Neurobehavioral Effects of Cyclohexane in Rat and Human

Autor: D.E. Owen, H.H. Emmen, Hans Muijser, B.M. Kulig, J.H.C.M. Lammers, E.M.G. Hoogendijk, Richard H. McKee

Publikováno v: International Journal of Toxicology, 6, 28, 488-497

The neurobehavioral effects of inhaled cyclohexane in rats and humans are investigated to define relationships between internal doses and acute central nervous system effects. Rats are exposed for 3 consecutive days at target concentrations of 0, 1.4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e01dfe5460b0024c90fa654ed583f4b
https://doi.org/10.1177/1091581809345534

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Molecular Characterization of Trimellitic Anhydride–induced Respiratory Allergy in Brown Norway Rats

Autor: Joost P. Bruijntjes, André Boorsma, Hans Muijser, Kitty C.M. Verhoeckx, Josje H.E. Arts, Rob H. Stierum, Marijana Radonjic, Marinus Dansen, Wilbert H. M. Heijne, C. Frieke Kuper

Publikováno v: Toxicologic pathology, 7, 36, 985-998

To contribute to the hazard identification of low molecular weight (LMW) respiratory allergens, respiratory allergy induced by trimellitic anhydride (TMA) was characterized by whole genome analysis of lung tissue and blood proteomics in Brown Norway

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc08d93897b2b068e1efc3230e7f9da
https://doi.org/10.1177/0192623308327410

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Effects of Cyclosporin A and Cyclophosphamide on Peyer’s Patches in Rat, Exposed in utero and Neonatally or During Adult Age

Autor: Maaike Van Zijverden, Mariska Tegelenbosch-Schouten, C. Frieke Kuper, Carlijn Klaassen, Andre Wolterbeek

Publikováno v: Toxicologic Pathology, 2, 35, 226-232

The effects of cyclosporin A (CY) and cyclophosphamide (CPS) on Peyer's patches (PP) were studied in Wistar rats, exposed in utero and neonatally or during adult age. In one study, pregnant dams received 5 or 15 mg/kg bw/day CY from gestation day 6 t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b1303b08f6dce53da44f92d6752476
https://doi.org/10.1080/01926230601156245

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The CD28/CTLA-4-B7 signaling pathway is involved in both allergic sensitization and tolerance induction to orally administered peanut proteins

Autor: Raymond Pieters, Ellen J. Wehrens, Louis Boon, Peter J.S. van Kooten, Stefan Nierkens, Wilco de Jong, Léon M.J. Knippels, Femke van Wijk

Publikováno v: Journal of Immunology, 11, 178, 6894-6900
Journal of Immunology, 178, 6894-900
Journal of Immunology, 178, 11, pp. 6894-900

Contains fulltext : 51645.pdf (Publisher’s version ) (Closed access) Dendritic cells are believed to play an essential role in regulating the balance between immunogenic and tolerogenic responses to mucosal Ags by controlling T cell differentiation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df4ef4938fd4835f5f3efac7284f265
https://hdl.handle.net/2066/51645

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Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in Brown Norway rats

Autor: Jonathan D. de Jonge, Raymond Pieters, Henk Van Loveren, Jennie Odink, André Penninks, Janine Ezendam, Léon M.J. Knippels, Milanthy S. Pourier

Publikováno v: Toxicology, 1-2, 239, 68-76
Toxicology, 239(1-2), 68-76. Elsevier Ireland Ltd

Other factors than the allergen itself may be of importance in the development of food allergy. This report describes the influence of the immunosuppressive compound bis(tributyltin)oxide (TBTO), present in the food chain, on the development of food

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e603ebe65a668c066d501785ab79e564
https://doi.org/10.1016/j.tox.2007.06.090

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Dose-Response Relationships and Threshold Levels in Skin and Respiratory Allergy

Autor: Josje H. E. Arts, Carolien Mommers, Cees de Heer

Publikováno v: Critical Reviews in Toxicology, 3, 36, 219-251

A literature study was performed to evaluate dose-response relationships and no-effect levels for sensitization and elicitation in skin- and respiratory allergy. With respect to the skin, dose-response relationships and no-effect levels were found fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639a373f422561aa8269be85e0868f81
https://doi.org/10.1080/10408440500534149

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Neurobehavioural evaluation and kinetics of inhalation of constant or fluctuating toluene concentrations in human volunteers

Autor: Hans Muijser, J.H.C.M. Lammers, J.G.M. Bessems, Wim J.A. Meuling, Andreas P. Freidig

Publikováno v: Environmental Toxicology and Pharmacology, 3, 20, 431-442

The health risks of inhalation exposure to volatile organic solvents may not only depend on the total external dose, but also on the pattern of exposure. It has been suggested that exposure to regularly occurring peak concentrations may have a strong

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd7c1fd2f8710487bf2942ce4315562
https://doi.org/10.1016/j.etap.2005.05.003

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Prenatal developmental toxicity study with 7-hydroxymatairesinol potassium acetate (HMRlignan) in rats

Autor: A Roberts, D.H Waalkens-Berendsen, M Unkila, H Korte, A.P.M Wolterbeek

Publikováno v: Regulatory Toxicology and Pharmacology, 1, 40, 1-8

Plant lignan 7-hydromatairesinol, a novel precursor of the mammalian lignan enterolactone was evaluated in a prenatal developmental toxicity study conducted in the Wistar rat. Mated female rats were fed diets containing 0, 0.25, 1, and 4% (w/w) of 7-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbfa844a2547c7145bffc7dbffe85790
https://doi.org/10.1016/j.yrtph.2004.04.001

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Embryotoxicity and teratogenicity study with neohesperidin dihydrochalcone in rats

Autor: A. Bär, D.H. Waalkens-Berendsen, M.E.M Kuilman-Wahls

Publikováno v: Regulatory Toxicology and Pharmacology, 1, 40, 74-79

The embryotoxicity/teratogenicity of neohesperidin dihydrochalcone (NHDC) was examined in Wistar Crl:(WI)WU BR rats. NHDC was fed at dietary concentrations of 0, 1.25, 2.5 or 5 to groups of 28 mated female rats from day 0 to 21 of gestation. At Cesar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97dc60705d9e0633fd15987394426b9d
https://doi.org/10.1016/j.yrtph.2004.05.007

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