Molecular and cellular toxicology : an introduction / Dr. Lesley A. Stanley. [elektronicky zdroj]

Autor: Stanley, Lesley, author

Externí odkaz: Kolekce e-knih KNAV

Workshop on acceleration of the validation and regulatory acceptance of alternative methods and implementation of testing strategies

Autor: Piersma, A H, Burgdorf, T, Louekari, K, Desprez, B, Taalman, R, Landsiedel, R, Barroso, J, Rogiers, V, Eskes, C, Oelgeschläger, M, Whelan, M, Braeuning, A, Vinggaard, A M, Kienhuis, A, van Benthem, J, Ezendam, J, Sub RIVM, dIRAS RA-1

Publikováno v: Piersma, A H, Burgdorf, T, Louekari, K, Desprez, B, Taalman, R, Landsiedel, R, Barroso, J, Rogiers, V, Eskes, C, Oelgeschläger, M, Whelan, M, Braeuning, A, Vinggaard, A M, Kienhuis, A, van Benthem, J & Ezendam, J 2018, ' Workshop on acceleration of the validation and regulatory acceptance of alternative methods and implementation of testing strategies ', Toxicology in Vitro, vol. 50, pp. 62-74 . https://doi.org/10.1016/j.tiv.2018.02.018
Toxicology in Vitro, 50, 62. NLM (Medline)

This report describes the proceedings of the BfR-RIVM workshop on validation of alternative methods which was held 23 and 24 March 2017 in Berlin, Germany. Stakeholders from governmental agencies, regulatory authorities, universities, industry and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045381594e3001d197f7f8ac98ab9db5
https://doi.org/10.1016/j.tiv.2018.02.018

Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes

Autor: Fritsche, Ellen, Grandjean, Philippe, Crofton, Kevin M, Aschner, Michael, Goldberg, Alan, Heinonen, Tuula, Hessel, Ellen V S, Hogberg, Helena T, Bennekou, Susanne Hougaard, Lein, Pamela J, Leist, Marcel, Mundy, William R, Paparella, Martin, Piersma, Aldert H, Sachana, Magdalini, Schmuck, Gabriele, Solecki, Roland, Terron, Andrea, Monnet-Tschudi, Florianne, Wilks, Martin F, Witters, Hilda, Zurich, Marie-Gabrielle, Bal-Price, Anna, Sub RIVM, dIRAS RA-1

Publikováno v: Toxicology and Applied Pharmacology
Toxicology and Applied Pharmacology, 354, 3. Academic Press Inc.
Fritsche, Ellen; Grandjean, Philippe; Crofton, Kevin M; Aschner, Michael; Goldberg, Alan; Heinonen, Tuula; et al.(2018). Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes.. Toxicology and applied pharmacology, 354, 3-6. doi: 10.1016/j.taap.2018.02.004. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/8g38c80h
Fritsche, E, Grandjean, P, Crofton, K M, Aschner, M, Goldberg, A, Heinonen, T, Hessel, E V S, Hogberg, H T, Bennekou, S H, Lein, P J, Leist, M, Mundy, W R, Paparella, M, Piersma, A H, Sachana, M, Schmuck, G, Solecki, R, Terron, A, Monnet-Tschudi, F, Wilks, M F, Witters, H, Zurich, M-G & Bal-Price, A 2018, ' Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes ', Toxicology and Applied Pharmacology, vol. 354, pp. 3-6 . https://doi.org/10.1016/j.taap.2018.02.004

This consensus statement voices the agreement of scientific stakeholders from regulatory agencies, academia and industry that a new framework needs adopting for assessment of chemicals with the potential to disrupt brain development. An increased pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0d81de43a1f9c1f946e667b9511151
http://europepmc.org/articles/PMC6097873

The urgency for optimization and harmonization of thyroid hormone analyses and their interpretation in developmental and reproductive toxicology studies

Autor: Beekhuijzen, Manon, Schneider, Steffen, Barraclough, Narinder, Hallmark, Nina, Hoberman, Alan, Lordi, Sheri, Moxon, Mary, Perks, Deborah, Piersma, Aldert H, Makris, Susan L, Sub RIVM, dIRAS RA-1

Publikováno v: Reproductigve Toxicoloy, 80, 126. Elsevier

In recent years several OECD test guidelines have been updated and some will be updated shortly with the requirement to measure thyroid hormone levels in the blood of mammalian laboratory species. There is, however, an imperative need for clarificati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a829ba6d1c7016025c8bc0936d4851a
https://dspace.library.uu.nl/handle/1874/374722

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity

Autor: Bal-Price, Anna, Hogberg, Helena T, Crofton, Kevin M, Daneshian, Mardas, FitzGerald, Rex E, Fritsche, Ellen, Heinonen, Tuula, Hougaard Bennekou, Susanne, Klima, Stefanie, Piersma, Aldert H, Sachana, Magdalini, Shafer, Timothy J, Terron, Andrea, Monnet-Tschudi, Florianne, Viviani, Barbara, Waldmann, Tanja, Westerink, Remco H S, Wilks, Martin F, Witters, Hilda, Zurich, Marie-Gabrielle, Leist, Marcel

Multiple non-animal-based test methods have never been formally validated. In order to use such new approach methods (NAMs) in a regulatory context, criteria to define their readiness are necessary. The field of developmental neurotoxicity (DNT) test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cfbc427e3d3f7e06b638bc3e6a6ada8c
http://hdl.handle.net/10029/621475