Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Toxic oligomers"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 1595-1602 (2021)
Poly glutamine and glutamine-rich peptides play a central role in a plethora of pathological aggregation events. However, biophysical characterization of soluble oligomers -the most toxic species involved in these processes- remains elusive due to th
Externí odkaz:
https://doaj.org/article/ec5ced50bc0f49d5bb16de881b3bc3e7
Autor:
Catherine K. Xu, Marta Castellana-Cruz, Serene W. Chen, Zhen Du, Georg Meisl, Aviad Levin, Benedetta Mannini, Laura S. Itzhaki, Tuomas P. J. Knowles, Christopher M. Dobson, Nunilo Cremades, Janet R. Kumita
Publikováno v:
Molecules, Vol 27, Iss 4, p 1293 (2022)
A wide variety of oligomeric structures are formed during the aggregation of proteins associated with neurodegenerative diseases. Such soluble oligomers are believed to be key toxic species in the related disorders; therefore, identification of the s
Externí odkaz:
https://doaj.org/article/22de59ffd416471b9dbd2a4adc27aee5
Autor:
Perni, Michele, Galvagnion, Céline, Maltsev, Alexander, Meisl, Georg, Müller, Martin B. D., Challa, Pavan K., Kirkegaard, Julius B., Flagmeier, Patrick, Cohen, Samuel I. A., Cascella, Roberta, Chen, Serene W., Limbocker, Ryan, Sormanni, Pietro, Heller, Gabriella T., Aprile, Francesco A., Cremades, Nunilo, Cecchi, Cristina, Chiti, Fabrizio, Nollen, Ellen A. A., Knowles, Tuomas P. J., Vendruscolo, Michele, Bax, Adriaan, Zasloff, Michael, Dobson, Christopher M.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2017 Feb 01. 114(6), E1009-E1017.
Externí odkaz:
https://www.jstor.org/stable/26479247
Autor:
Roberta Cascella, Cristina Cecchi
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4914 (2021)
Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder that is characterized by amyloid β-protein deposition in senile plaques, neurofibrillary tangles consisting of abnormally phosphorylated tau protein, and neuronal l
Externí odkaz:
https://doaj.org/article/29b12d8fbb4d4ee48b2d06f9290640a9
Publikováno v:
Life, Vol 11, Iss 5, p 431 (2021)
α-Synuclein (αS) is an intrinsically disordered and highly dynamic protein involved in dopamine release at presynaptic terminals. The abnormal aggregation of αS as mature fibrils into intraneuronal inclusion bodies is directly linked to Parkinson
Externí odkaz:
https://doaj.org/article/9780ceb0824c4c369a1076c296215bb5
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7443 (2020)
One of the most commonly occurring neurodegenerative disorders, Alzheimer’s disease (AD), encompasses the loss of cognitive and memory potential, impaired learning, dementia and behavioral defects, and has been prevalent since the 1900s. The accele
Externí odkaz:
https://doaj.org/article/e6e5bcbfd9214d6ca5119468808ade29
Akademický článek
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Autor:
Hazel L. Roberts, David R. Brown
Publikováno v:
Biomolecules, Vol 5, Iss 2, Pp 282-305 (2015)
In a number of neurological diseases including Parkinson’s disease (PD), α‑synuclein is aberrantly folded, forming abnormal oligomers, and amyloid fibrils within nerve cells. Strong evidence exists for the toxicity of increased production and ag
Externí odkaz:
https://doaj.org/article/0380f55dbfce48a88c2d81ca0c381903
Autor:
Luisa Diomede, Giuseppe Di Fede, Margherita Romeo, Renzo Bagnati, Roberta Ghidoni, Fabio Fiordaliso, Monica Salio, Alessandro Rossi, Marcella Catania, Anna Paterlini, Luisa Benussi, Antonio Bastone, Matteo Stravalaci, Marco Gobbi, Fabrizio Tagliavini, Mario Salmona
Publikováno v:
Neurobiology of Disease, Vol 62, Iss , Pp 521-532 (2014)
Although Alzheimer's disease (AD) is usually sporadic, in a small proportion of cases it is familial and can be linked to mutations in β-amyloid precursor protein (APP). Unlike the other genetic defects, the mutation [alanine-673→valine-673] (A673
Externí odkaz:
https://doaj.org/article/1be080dfcc94491f9bba46b21ce8c636
Autor:
Elena E. Ferapontova
Publikováno v:
Ferapontova, E E 2022, ' Bioelectrochemical analysis of neurodegeneration : Refocusing efforts ', Current Opinion in Electrochemistry, vol. 32, 100924 . https://doi.org/10.1016/j.coelec.2021.100924
Since 1970s, electrochemistry is enthusiastically used for studies of severe neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, or prion-associated transmissible spongiform encephalopathies, associated with the neuronal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d940d5299a6da52a0796338fd6cead
https://pure.au.dk/portal/da/publications/bioelectrochemical-analysis-of-neurodegeneration(99efdd65-fee3-4a4d-bd3a-73b222db501a).html
https://pure.au.dk/portal/da/publications/bioelectrochemical-analysis-of-neurodegeneration(99efdd65-fee3-4a4d-bd3a-73b222db501a).html
