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pro vyhledávání: '"Townsend-Nicholson A"'
Autor:
Townsend-Nicholson A; Research Department of Structural & Molecular Biology, Division of Biosciences, University College London, London, UK. a.townsend-nicholson@ucl.ac.uk.
Publikováno v:
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2024; Vol. 2716, pp. 413-420.
Autor:
Martin RL; Research Department of Structural & Molecular Biology, Division of Biosciences, University College London, London, UK. reuben.martin.18@ucl.ac.uk.; Evotec (UK) Ltd., Abingdon, Oxfordshire, UK. reuben.martin.18@ucl.ac.uk., Heifetz A; In Silico Research and Development, Evotec UK Ltd., Abingdon, UK. alexander.heifetz@evotec.com., Bodkin MJ; Evotec (UK) Ltd., Abingdon, Oxfordshire, UK., Townsend-Nicholson A; Research Department of Structural & Molecular Biology, Division of Biosciences, University College London, London, UK.
Publikováno v:
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2024; Vol. 2716, pp. 293-306.
Akademický článek
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Publikováno v:
Journal of personalized medicine. 12(10)
The G protein-coupled receptor (GPCR) Smoothened (Smo) is a central signal transducer of the Hedgehog (Hh) pathway which has been linked to diverse forms of tumours. Stimulated by advancements in structural and functional characterisation, the Smo re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8844aa9dc17c9eb7cbe7ccb7f0bf207f
https://pubmed.ncbi.nlm.nih.gov/36294790
https://pubmed.ncbi.nlm.nih.gov/36294790
Autor:
Stefania Monteleone, Dmitri G. Fedorov, Andrea Townsend-Nicholson, Michelle Southey, Michael Bodkin, Alexander Heifetz
Publikováno v:
Journal of chemical information and modeling. 62(16)
Protein-protein interactions (PPIs) are essential for the function of many proteins. Aberrant PPIs have the potential to lead to disease, making PPIs promising targets for drug discovery. There are over 64,000 PPIs in the human interactome reference
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749e987fedc984e4013b9d707ddb6a9d
https://pubmed.ncbi.nlm.nih.gov/35939049
https://pubmed.ncbi.nlm.nih.gov/35939049
Akademický článek
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Akademický článek
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Publikováno v:
Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology. 50(5)
The final year of a biochemistry degree is usually a time to experience research. However, laboratory-based research projects were not possible during COVID-19. Instead, we used open datasets to provide computational research projects in metagenomics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8381b9451fac9bdcd0f62d38a3e398
https://pubmed.ncbi.nlm.nih.gov/35972192
https://pubmed.ncbi.nlm.nih.gov/35972192
Publikováno v:
Artificial Intelligence in Drug Design ISBN: 9781071617861
Drug-target residence time, the duration of binding at a given protein target, has been shown in some protein families to be more significant for conferring efficacy than binding affinity. To carry out efficient optimization of residence time in drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae909e9bc2eb004d8dfb46df2ea6ac17
https://doi.org/10.1007/978-1-0716-1787-8_8
https://doi.org/10.1007/978-1-0716-1787-8_8
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2390
Drug-target residence time, the duration of binding at a given protein target, has been shown in some protein families to be more significant for conferring efficacy than binding affinity. To carry out efficient optimization of residence time in drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::482a84fb0fc8d8ec8525f9321cc09afc
https://pubmed.ncbi.nlm.nih.gov/34731470
https://pubmed.ncbi.nlm.nih.gov/34731470