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Qualification of a multiplexed tissue imaging assay and detection of novel patterns of HER2 heterogeneity in breast cancer.

Autor: Guerriero JL; Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, 02115, USA. JGuerriero@bwh.harvard.edu.; Breast Tumor Immunology Laboratory, Dana-Farber Cancer Institute, Boston, MA, 02215, USA. JGuerriero@bwh.harvard.edu.; Ludwig Center for Cancer Research at Harvard, Harvard Medical School, Boston, MA, 02215, USA. JGuerriero@bwh.harvard.edu.; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA, 02215, USA. JGuerriero@bwh.harvard.edu., Lin JR; Ludwig Center for Cancer Research at Harvard, Harvard Medical School, Boston, MA, 02215, USA.; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA, 02215, USA., Pastorello RG; Breast Tumor Immunology Laboratory, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Department of Pathology, Hospital Sírio Libanês, São Paulo, SP, 01308-050, Brazil., Du Z; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, Guangzhou, China., Chen YA; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA, 02215, USA., Townsend MG; Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Breast Tumor Immunology Laboratory, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Shimada K; Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Breast Tumor Immunology Laboratory, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Ludwig Center for Cancer Research at Harvard, Harvard Medical School, Boston, MA, 02215, USA.; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA, 02215, USA., Hughes ME; Breast Oncology Program, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA, 02215, USA., Ren S; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Tayob N; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Zheng K; Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, 02115, USA., Mei S; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA, 02215, USA., Patterson A; Breast Oncology Program, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA, 02215, USA., Taneja KL; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Metzger O; Breast Oncology Program, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA, 02215, USA., Tolaney SM; Breast Oncology Program, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA, 02215, USA., Lin NU; Breast Oncology Program, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA, 02215, USA., Dillon DA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Schnitt SJ; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Sorger PK; Ludwig Center for Cancer Research at Harvard, Harvard Medical School, Boston, MA, 02215, USA.; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA, 02215, USA., Mittendorf EA; Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Breast Tumor Immunology Laboratory, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Ludwig Center for Cancer Research at Harvard, Harvard Medical School, Boston, MA, 02215, USA.; Breast Oncology Program, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA, 02215, USA., Santagata S; Ludwig Center for Cancer Research at Harvard, Harvard Medical School, Boston, MA, 02215, USA.; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA, 02215, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

Publikováno v: NPJ breast cancer [NPJ Breast Cancer] 2024 Jan 02; Vol. 10 (1), pp. 2. Date of Electronic Publication: 2024 Jan 02.

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Akademický článek

Comparing syngeneic and autochthonous models of breast cancer to identify tumor immune components that correlate with response to immunotherapy in breast cancer.

Autor: Lal JC; Breast Tumor Immunology Laboratory, Susan F. Smith Center for Women's Cancers, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA.; Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA., Townsend MG; Breast Tumor Immunology Laboratory, Susan F. Smith Center for Women's Cancers, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA.; Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, 02115, USA., Mehta AK; Breast Tumor Immunology Laboratory, Susan F. Smith Center for Women's Cancers, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA., Oliwa M; Breast Tumor Immunology Laboratory, Susan F. Smith Center for Women's Cancers, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA.; Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, 02115, USA., Miller E; Nanostring Technologies, Seattle, WA, USA., Sotayo A; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA., Cheney E; Breast Tumor Immunology Laboratory, Susan F. Smith Center for Women's Cancers, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA., Mittendorf EA; Breast Tumor Immunology Laboratory, Susan F. Smith Center for Women's Cancers, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA.; Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Breast Oncology Program, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA, USA.; Ludwig Center for Cancer Research at Harvard, Harvard Medical School, Boston, MA, USA., Letai A; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA.; Ludwig Center for Cancer Research at Harvard, Harvard Medical School, Boston, MA, USA., Guerriero JL; Breast Tumor Immunology Laboratory, Susan F. Smith Center for Women's Cancers, Dana-Farber Cancer Institute, Boston, MA, USA. JGuerriero@bwh.harvard.edu.; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA. JGuerriero@bwh.harvard.edu.; Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, 02115, USA. JGuerriero@bwh.harvard.edu.; Breast Oncology Program, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA, USA. JGuerriero@bwh.harvard.edu.; Ludwig Center for Cancer Research at Harvard, Harvard Medical School, Boston, MA, USA. JGuerriero@bwh.harvard.edu.

Publikováno v: Breast cancer research : BCR [Breast Cancer Res] 2021 Aug 05; Vol. 23 (1), pp. 83. Date of Electronic Publication: 2021 Aug 05.

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Akademický článek

Macrophage Biology and Mechanisms of Immune Suppression in Breast Cancer.

Autor: Mehta AK; Breast Tumor Immunology Laboratory, Dana-Farber Cancer Institute, Boston, MA, United States.; Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, United States., Kadel S; Breast Tumor Immunology Laboratory, Dana-Farber Cancer Institute, Boston, MA, United States., Townsend MG; Breast Tumor Immunology Laboratory, Dana-Farber Cancer Institute, Boston, MA, United States.; Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, United States., Oliwa M; Breast Tumor Immunology Laboratory, Dana-Farber Cancer Institute, Boston, MA, United States.; Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, United States., Guerriero JL; Breast Tumor Immunology Laboratory, Dana-Farber Cancer Institute, Boston, MA, United States.; Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2021 Apr 23; Vol. 12, pp. 643771. Date of Electronic Publication: 2021 Apr 23 (Print Publication: 2021).

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