Výsledky vyhledávání - "Tove, Olafsen"

Akademický článek

PET imaging and treatment of pancreatic cancer peritoneal carcinomatosis after subcutaneous intratumoral administration of a novel oncolytic virus, CF33-hNIS-antiPDL1

Autor: Zhifang Zhang, Annie Yang, Shyambabu Chaurasiya, Anthony K. Park, Sang-In Kim, Jianming Lu, Tove Olafsen, Susanne G. Warner, Yuman Fong, Yanghee Woo

Publikováno v: Molecular Therapy: Oncolytics, Vol 24, Iss , Pp 331-339 (2022)

Peritoneal carcinomatosis of gastrointestinal malignancies remains fatal. CF33-hNIS-antiPDL1, a chimeric orthopoxvirus expressing the human sodium iodide symporter (hNIS) and anti-human programmed death-ligand 1 antibody, has demonstrated robust prec

Externí odkaz: https://doaj.org/article/b136a546a3ad407fb2d3b3567d1fefc5

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Akademický článek

A comprehensive preclinical study supporting clinical trial of oncolytic chimeric poxvirus CF33-hNIS-anti-PD-L1 to treat breast cancer

Autor: Shyambabu Chaurasiya, Annie Yang, Zhifang Zhang, Jianming Lu, Hannah Valencia, Sang-In Kim, Yanghee Woo, Suanne G. Warner, Tove Olafsen, Yuqi Zhao, Xiwei Wu, Seymour Fein, Linda Cheng, Maria Cheng, Nicholas Ede, Yuman Fong

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 102-116 (2022)

CF33-hNIS-anti-PD-L1 is an oncolytic chimeric poxvirus encoding two transgenes: human sodium iodide symporter and a single-chain variable fragment against PD-L1. Comprehensive preclinical pharmacology studies encompassing primary and secondary pharma

Externí odkaz: https://doaj.org/article/970c8e52369d4fbd868c37193c54a126

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Akademický článek

Targeted alpha therapy with astatine-211-labeled anti-PSCA A11 minibody shows antitumor efficacy in prostate cancer xenografts and bone microtumors

Autor: Tom A. Bäck, Karin Jennbacken, Malin Hagberg Thulin, Sture Lindegren, Holger Jensen, Tove Olafsen, Paul J. Yazaki, Stig Palm, Per Albertsson, Jan-Erik Damber, Anna M. Wu, Karin Welén

Publikováno v: EJNMMI Research, Vol 10, Iss 1, Pp 1-12 (2020)

Abstract Purpose Targeted alpha therapy (TAT) is a promising treatment for micrometastatic and minimal residual cancer. We evaluated systemic α-radioimmunotherapy (α-RIT) of metastatic castration-resistant prostate cancer (mCRPC) using the α-parti

Externí odkaz: https://doaj.org/article/cb79622cfe444d258013759e1047e094

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Akademický článek

Heart Uptake of [18F]Fluoro-4-Thia-Oleate in a Non-Alcoholic Fatty Liver Disease Mouse Model

Autor: Junfeng Li, Weidong Hu, Jiangling Peng, Patty Wong, Fouad Kandeel, Tove Olafsen, John E. Shively

Publikováno v: Pharmaceuticals, Vol 15, Iss 12, p 1577 (2022)

The world-wide high incidence of non-alcoholic fatty liver disease (NAFLD) is of concern for its progression to insulin resistance, steatohepatitis and cardiovascular disease (CVD). The increased uptake of fatty acids in critical organs plays a major

Externí odkaz: https://doaj.org/article/3f9c736a80a54457bdf7222f4732c34c

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Akademický článek

Biodistribution of Intra-Arterial and Intravenous Delivery of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in a Rat Model to Guide Delivery Strategies for Diabetes Therapies

Autor: Junfeng Li, Hirotake Komatsu, Erasmus K. Poku, Tove Olafsen, Kelly X. Huang, Lina A. Huang, Junie Chea, Nicole Bowles, Betty Chang, Jeffrey Rawson, Jiangling Peng, Anna M. Wu, John E. Shively, Fouad R. Kandeel

Publikováno v: Pharmaceuticals, Vol 15, Iss 5, p 595 (2022)

Umbilical cord mesenchymal stem cell-derived extracellular vesicles (UC-MSC-EVs) have become an emerging strategy for treating various autoimmune and metabolic disorders, particularly diabetes. Delivery of UC-MSC-EVs is essential to ensure optimal ef

Externí odkaz: https://doaj.org/article/fc5d815ac8214fe2a4665d2d91fb950d

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Akademický článek

Identification of miRNA signatures associated with radiation-induced late lung injury in mice.

Autor: Claude J Rogers, Agnes I Lukaszewicz, Jason Yamada-Hanff, Ewa D Micewicz, Josephine A Ratikan, Mark A Starbird, Thomas A Miller, Christine Nguyen, Jason T Lee, Tove Olafsen, Keisuke S Iwamoto, William H McBride, Dörthe Schaue, Naresh Menon

Publikováno v: PLoS ONE, Vol 15, Iss 5, p e0232411 (2020)

Acute radiation exposure of the thorax can lead to late serious, and even life-threatening, pulmonary and cardiac damage. Sporadic in nature, late complications tend to be difficult to predict, which prompted this investigation into identifying non-i

Externí odkaz: https://doaj.org/article/9ef236df45954e98bbb80c111b9106d1

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