Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Tovah A. Day"'
Autor:
Ke Cong, Nathan MacGilvary, Silviana Lee, Shannon G. MacLeod, Jennifer Calvo, Min Peng, Arne Nedergaard Kousholt, Tovah A. Day, Sharon B. Cantor
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The effectiveness of poly (ADP-ribose) polymerase inhibitors (PARPi) in creating single-stranded DNA gaps and inducing sensitivity requires the FANCJ DNA helicase. Yet, how FANCJ relates to PARP1 inhibition or trapping, which contribute to P
Externí odkaz:
https://doaj.org/article/f2a25b0a9e8844edac2e653b074386d2
Pgc-1α controls epidermal stem cell fate and skin repair by sustaining NAD+ homeostasis during aging
Autor:
Wesley Wong, Elizabeth D. Crane, Hui Zhang, Jiahe Li, Tovah A. Day, Alex E. Green, Keir J. Menzies, Justin D. Crane
Publikováno v:
Molecular Metabolism, Vol 65, Iss , Pp 101575- (2022)
Objective: The epidermal barrier is renewed by the activation, proliferation, and differentiation of keratinocyte stem cells after injury and aging impedes this repair process through undefined mechanisms. We previously identified a gene signature of
Externí odkaz:
https://doaj.org/article/7e3ab768e88f4099a66bb1191480b146
Autor:
Tovah A. Day, Jacob V. Layer, J. Patrick Cleary, Srijoy Guha, Kristen E. Stevenson, Trevor Tivey, Sunhee Kim, Anna C. Schinzel, Francesca Izzo, John Doench, David E. Root, William C. Hahn, Brendan D. Price, David M. Weinstock
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Chromosomal rearrangements are key events in the pathogenesis of a range of disorders. Here the authors utilize a zinc finger nuclease translocation reporter to identify PARP3 as a regulator of these events at sites enriched for G quadruplex DNA.
Externí odkaz:
https://doaj.org/article/bbb73c46fe524682b8101ab1da9d52fc
Autor:
Young Eun Choi, Khyati Meghani, Marie-Eve Brault, Lucas Leclerc, Yizhou J. He, Tovah A. Day, Kevin M. Elias, Ronny Drapkin, David M. Weinstock, Fanny Dao, Karin K. Shih, Ursula Matulonis, Douglas A. Levine, Panagiotis A. Konstantinopoulos, Dipanjan Chowdhury
Publikováno v:
Cell Reports, Vol 14, Iss 3, Pp 429-439 (2016)
High-grade serous ovarian carcinomas (HGSOCs) with BRCA1/2 mutations exhibit improved outcome and sensitivity to double-strand DNA break (DSB)-inducing agents (i.e., platinum and poly(ADP-ribose) polymerase inhibitors [PARPis]) due to an underlying d
Externí odkaz:
https://doaj.org/article/dc85450a47e44ae48eb08de310818370
Autor:
Tovah A. Day, Jacob V. Layer, J. Patrick Cleary, Srijoy Guha, Kristen E. Stevenson, Trevor Tivey, Sunhee Kim, Anna C Schinzel, Francesca Izzo, John Doench, David E. Root, William C. Hahn, Brendan D. Price, David M. Weinstock
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 8: Article number: 15110 (2017); Published: 27 Apr 2017; Updated: 13 Jun 2017 In this Article, the antibody ‘BG4’ is consistently referred to incorrectly as ‘hf2’. These errors appear in the Results and Methods. Addition
Externí odkaz:
https://doaj.org/article/33d89e69f3c3479ba5e142d3eeee307f
Publikováno v:
Oncogene
Mutagenesis is a key hallmark and enabling characteristic of cancer cells, yet the diverse underlying mutagenic mechanisms that shape cancer genomes are not understood. This review will consider the emerging challenge of determining how DNA damage re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::330cab2c36211e8de2cdfc80803299ce
http://europepmc.org/articles/PMC8639439
http://europepmc.org/articles/PMC8639439
Autor:
Michael T. Hemann, Alexandria Van Scoyk, Jacob V. Layer, Alexander J. Brown, Tovah A. Day, Yunpeng Liu, Brendan D. Price, Steven A. Roberts, Kristen E. Stevenson, Nealia C.M. House, David M. Weinstock, Lydie Debaize
Publikováno v:
Proc Natl Acad Sci U S A
Recent studies have implicated DNA polymerases θ (Pol θ) and β (Pol β) as mediators of alternative nonhomologous end-joining (Alt-NHEJ) events, including chromosomal translocations. Here we identify subunits of the replicative DNA polymerase δ (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3003fff880d2d483ebaf9db588ff6cec
https://doi.org/10.1073/pnas.2014176117
https://doi.org/10.1073/pnas.2014176117
Autor:
Michael L. Durando, Sanjay V. Menghani, Jessica L. Baumann, Danny G. Robles, Tovah A. Day, Cyrus Vaziri, Aaron J. Scott
Publikováno v:
Journal of the National Comprehensive Cancer Network : JNCCN. 20(3)
The stability of the human genome depends upon a delicate balance between replication by high- and low-fidelity DNA polymerases. Aberrant replication by error-prone polymerases or loss of function of high-fidelity polymerases predisposes to genetic i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc99859c3a1c45e857908f546a21b4ba
https://pubmed.ncbi.nlm.nih.gov/35276675
https://pubmed.ncbi.nlm.nih.gov/35276675
Publikováno v:
Trends in Genetics. 35:159-172
Although stress-induced synthesis of mono(ADP-ribose) (mADPr) and poly(ADP-ribose) (pADPr) conjugates by pADPr polymerase (PARP) enzymes has been studied extensively, the removal and degradation of pADPr, as well as the fate of ADPr metabolites, have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839e744ef26668149074712e8091b47c
https://doi.org/10.1016/j.tig.2018.12.002
https://doi.org/10.1016/j.tig.2018.12.002
Autor:
William C. Hahn, David E. Root, Anna C. Schinzel, J. Patrick Cleary, David M. Weinstock, Brendan D. Price, Srijoy Guha, John G. Doench, Jacob V. Layer, Tovah A. Day, Trevor Tivey, Kristen E. Stevenson, Sunhee Kim, Francesca Izzo
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications
Chromosomal rearrangements are essential events in the pathogenesis of both malignant and nonmalignant disorders, yet the factors affecting their formation are incompletely understood. Here we develop a zinc-finger nuclease translocation reporter and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf539731a508d815dd4c40eb87c6bba
https://doaj.org/article/bbb73c46fe524682b8101ab1da9d52fc
https://doaj.org/article/bbb73c46fe524682b8101ab1da9d52fc