Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Toufike Kanouni"'
Autor:
Delphine Duteil, Milica Tosic, Franziska Lausecker, Hatice Z. Nenseth, Judith M. Müller, Sylvia Urban, Dominica Willmann, Kerstin Petroll, Nadia Messaddeq, Laura Arrigoni, Thomas Manke, Jan-Wilhelm Kornfeld, Jens C. Brüning, Vyacheslav Zagoriy, Michael Meret, Jörn Dengjel, Toufike Kanouni, Roland Schüle
Publikováno v:
Cell Reports, Vol 17, Iss 4, Pp 1008-1021 (2016)
Previous work indicated that lysine-specific demethylase 1 (Lsd1) can positively regulate the oxidative and thermogenic capacities of white and beige adipocytes. Here we investigate the role of Lsd1 in brown adipose tissue (BAT) and find that BAT-sel
Externí odkaz:
https://doaj.org/article/15acdfef4129450fb67865a1bd83d169
Autor:
Roland Schüle, Jochen Maurer, Toufike Kanouni, Jeffrey A. Stafford, Michael B. Wallace, Jiangchun Xu, Elmar Stickeler, Melanie Boerries, Marie Follo, Amelie Proske, Peter Bronsert, Nicola Iovino, Fides Zenk, Anita Allen, Dominica Willmann, Sylvia Urban, Bogdan-Tiberius Preca, Juliane Strietz, Stella S. Stepputtis, Eric Metzger
This file contains the legends to all Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5761318b1f6435dcbf3e792e5a2fa818
https://doi.org/10.1158/0008-5472.22419060.v1
https://doi.org/10.1158/0008-5472.22419060.v1
Autor:
Roland Schüle, Jochen Maurer, Toufike Kanouni, Jeffrey A. Stafford, Michael B. Wallace, Jiangchun Xu, Elmar Stickeler, Melanie Boerries, Marie Follo, Amelie Proske, Peter Bronsert, Nicola Iovino, Fides Zenk, Anita Allen, Dominica Willmann, Sylvia Urban, Bogdan-Tiberius Preca, Juliane Strietz, Stella S. Stepputtis, Eric Metzger
H3K9me3 levels increase upon treatment with QC6352. Changes in H3K9me3 levels are depicted according to genomic location.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03971b883243e51d248ae86c72123875
https://doi.org/10.1158/0008-5472.22419069
https://doi.org/10.1158/0008-5472.22419069
Autor:
Roland Schüle, Jochen Maurer, Toufike Kanouni, Jeffrey A. Stafford, Michael B. Wallace, Jiangchun Xu, Elmar Stickeler, Melanie Boerries, Marie Follo, Amelie Proske, Peter Bronsert, Nicola Iovino, Fides Zenk, Anita Allen, Dominica Willmann, Sylvia Urban, Bogdan-Tiberius Preca, Juliane Strietz, Stella S. Stepputtis, Eric Metzger
Traditional treatments for breast cancer fail to address therapy-resistant cancer stem–like cells that have been characterized by changes in epigenetic regulators such as the lysine demethylase KDM4. Here, we describe an orally available, selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::568147c1824ce1c828b615cb332bfec3
https://doi.org/10.1158/0008-5472.c.6510285.v1
https://doi.org/10.1158/0008-5472.c.6510285.v1
Autor:
David J. Hosfield, Jiangchun Xu, Young K. Chen, Matt M. Kreilein, James Marvin Veal, Chon Lai, Christophe Severin, Toufike Kanouni, Stephen W. Kaldor, Lee N. Lawton, Robert Cho, Joselyn R. Del Rosario, Ryan Stansfield, Jeffrey A. Stafford, Natalie Y.-Y. Yuen, Shawn O’Connell, Paula Alessandra Tavares-Greco, Zhe Nie, Lihong Shi
Publikováno v:
Journal of Medicinal Chemistry. 63:14522-14529
Histone demethylase LSDl (KDMlA) belongs to the flavin adenine dinucleotide (FAD) dependent family of monoamine oxidases and is vital in regulation of mammalian biology. Dysregulation and overexpression of LSD1 are hallmarks of a number of human dise
Autor:
Nichol L. G. Miller, Tim S. Wang, Paul Severson, Ping Jiang, Michelle Perez, Noel Timple, Toufike Kanouni, Aleksandra Franovic, Eric S. Martin, Eric Murphy
Publikováno v:
Cancer Research. 82:2674-2674
Background: In the US in 2021, invasive melanoma will account for an estimated 106,000 new cases and > 7,000 deaths. Somatic mutations that activate the MAPK signaling pathway are a leading cause of melanoma with 50% harboring oncogenic BRAF alterati
Autor:
Anita Allen, Marie Follo, Sylvia Urban, Roland Schüle, Jochen Maurer, Stella S. Stepputtis, Melanie Boerries, Jeffrey A. Stafford, Dominica Willmann, Peter Bronsert, Fides Zenk, Toufike Kanouni, Juliane Strietz, Michael Brennan Wallace, Nicola Iovino, Jiangchun Xu, Eric Metzger, Amelie Proske, Bogdan-Tiberius Preca, Elmar Stickeler
Publikováno v:
Cancer research : an official organ of the American Association for Cancer Research
Traditional treatments for breast cancer fail to address therapy-resistant cancer stem–like cells that have been characterized by changes in epigenetic regulators such as the lysine demethylase KDM4. Here, we describe an orally available, selective
Autor:
Joselyn R. Del Rosario, James M. Veal, Young K. Chen, Lihong Shi, Zhe Nie, Ryan Stansfield, Christophe Severin, Chon Lai, Robert Cho, Toufike Kanouni, Jiangchun Xu, Jeffrey A. Stafford
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(1)
The histone demethylase LSD1 is a key enzyme in the epigenetic regulation of gene transcription. Here we present our efforts to discover small molecule reversible inhibitors of LSD1 as an attractive approach to treat hematologic malignancies and cert
Autor:
Beverly M. Knight, Smith Christopher, Phong H. Vu, Corey Wyrick, J. David Lawson, Mallareddy Komandla, Toufike Kanouni, Ewan Taylor, Mark Sabat, Douglas R. Dougan
Publikováno v:
Journal of Medicinal Chemistry. 58:5437-5444
The discovery and optimization of a series of 4-aminocinnoline-3-carboxamide inhibitors of Bruton's tyrosine kinase are reported. A fragment-based screening approach incorporating X-ray co-crystallography was used to identify a cinnoline fragment and
Autor:
Andrew McGeehan, Joselyn R. Del Rosario, Young K. Chen, Lihong Shi, James M. Veal, Michael S. Weiss, David J. Hosfield, Alessandro Cuomo, Neethan A. Lobo, Jennifer Matuszkiewicz, Shih Chu Kao, Jeffrey A. Stafford, Tiziana Bonaldi, Michael Brennan Wallace, Natalie Y. Yuen, Ryan Stansfield, Shawn M. O'Connell, Chon Lai, Toufike Kanouni
Publikováno v:
ACS medicinal chemistry letters. 8(8)
Histone lysine demethylases (KDMs) play a vital role in the regulation of chromatin-related processes. Herein, we describe our discovery of a series of potent KDM4 inhibitors that are both cell permeable and antiproliferative in cancer models. The mo