SorCS2 deletion leads to altered neuronal lysosome activity

Autor: Oliveira Tg, Almeida Sec, Toth Ae, Nielsen Ms, Miranda Am

Vps10p domain receptors are important for regulating intracellular protein sorting within the central nervous system and as such constitute risk factors for different brain pathologies. Here, we show that removal of SorCS2 leads to altered lysosomal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df42a83423b07332b44c9ae3e347404d
https://doi.org/10.1101/2021.04.08.439000

Sortilin regulates blood-brain barrier integrity.

Autor: Toth AE; Department of Biomedicine, Faculty of Health, Aarhus University, Denmark.; Lundbeck Foundation Research Initiative on Brain Barriers and Drug Delivery, Copenhagen, Denmark., Helms HC; Lundbeck Foundation Research Initiative on Brain Barriers and Drug Delivery, Copenhagen, Denmark.; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Harazin A; Department of Biomedicine, Faculty of Health, Aarhus University, Denmark., Johnsen KB; Lundbeck Foundation Research Initiative on Brain Barriers and Drug Delivery, Copenhagen, Denmark.; Department of Health Technology, Section for Biotherapeutic Engineering and Drug Targeting, Technical University of Denmark, Lyngby, Denmark., Goldeman C; Lundbeck Foundation Research Initiative on Brain Barriers and Drug Delivery, Copenhagen, Denmark.; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Burkhart A; Lundbeck Foundation Research Initiative on Brain Barriers and Drug Delivery, Copenhagen, Denmark.; Laboratory of Neurobiology, Biomedicine Group, Department of Health Science and Technology, Aalborg University, Denmark., Thomsen MS; Lundbeck Foundation Research Initiative on Brain Barriers and Drug Delivery, Copenhagen, Denmark.; Laboratory of Neurobiology, Biomedicine Group, Department of Health Science and Technology, Aalborg University, Denmark., Kempen PJ; Lundbeck Foundation Research Initiative on Brain Barriers and Drug Delivery, Copenhagen, Denmark.; Department of Health Technology, Section for Biotherapeutic Engineering and Drug Targeting, Technical University of Denmark, Lyngby, Denmark., Klepe A; Department of Biomedicine, Faculty of Health, Aarhus University, Denmark., Lipka DV; Department of Biomedicine, Faculty of Health, Aarhus University, Denmark., Møller PL; Department of Biomedicine, Faculty of Health, Aarhus University, Denmark., Andresen TL; Lundbeck Foundation Research Initiative on Brain Barriers and Drug Delivery, Copenhagen, Denmark.; Department of Health Technology, Section for Biotherapeutic Engineering and Drug Targeting, Technical University of Denmark, Lyngby, Denmark., Nyegaard M; Department of Biomedicine, Faculty of Health, Aarhus University, Denmark., Moos T; Lundbeck Foundation Research Initiative on Brain Barriers and Drug Delivery, Copenhagen, Denmark.; Laboratory of Neurobiology, Biomedicine Group, Department of Health Science and Technology, Aalborg University, Denmark., Brodin B; Lundbeck Foundation Research Initiative on Brain Barriers and Drug Delivery, Copenhagen, Denmark.; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Nielsen MS; Department of Biomedicine, Faculty of Health, Aarhus University, Denmark.; Lundbeck Foundation Research Initiative on Brain Barriers and Drug Delivery, Copenhagen, Denmark.

Publikováno v: The FEBS journal [FEBS J] 2022 Feb; Vol. 289 (4), pp. 1062-1079. Date of Electronic Publication: 2021 Oct 20.

Giant and multiple cardiac papillary fibroelastomas masquerading as acute cerebrovascular events.

Autor: Teodoru CA; Department of Ophthalmology, Department of Biochemistry, Victor Babeş University of Medicine and Pharmacy, Timişoara, Romania; sutamarius@yahoo.ro, dia_bonte@yahoo.com., Preda MA, Borugă VM, Şuţă MC, Dărăbuş DM, Toth AE, Al Barri L, Cornea RF, Grigorescu AE, Bonţe DC, Stanca S, Feier HB

Publikováno v: Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie [Rom J Morphol Embryol] 2020 Jul-Sep; Vol. 61 (3), pp. 947-951.

The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells.

Autor: Toth AE; Department of Biomedicine, Faculty of Health, Aarhus University, Ole Worms Allé 3, 8000, Aarhus, Denmark. toth@biomed.au.dk.; Lundbeck Foundation, Research Initiative on Brain Barriers and Drug Delivery, Scherfigsvej 7, 2100, Copenhagen, Denmark. toth@biomed.au.dk., Nielsen SSE; Department of Biomedicine, Faculty of Health, Aarhus University, Ole Worms Allé 3, 8000, Aarhus, Denmark.; Lundbeck Foundation, Research Initiative on Brain Barriers and Drug Delivery, Scherfigsvej 7, 2100, Copenhagen, Denmark., Tomaka W; Department of Biomedicine, Faculty of Health, Aarhus University, Ole Worms Allé 3, 8000, Aarhus, Denmark., Abbott NJ; Institute of Pharmaceutical Science, King's College London, 150 Stamford Street, SE1 9NH, London, UK., Nielsen MS; Department of Biomedicine, Faculty of Health, Aarhus University, Ole Worms Allé 3, 8000, Aarhus, Denmark. mn@biomed.au.dk.; Lundbeck Foundation, Research Initiative on Brain Barriers and Drug Delivery, Scherfigsvej 7, 2100, Copenhagen, Denmark. mn@biomed.au.dk.

Publikováno v: Fluids and barriers of the CNS [Fluids Barriers CNS] 2019 May 30; Vol. 16 (1), pp. 14. Date of Electronic Publication: 2019 May 30.

The Endo-Lysosomal System of Brain Endothelial Cells Is Influenced by Astrocytes In Vitro.

Autor: Toth AE; Department of Biomedicine, Faculty of Health, Aarhus University, Ole Worms Allé 3, 8000, Aarhus, Denmark.; Lundbeck Foundation, Research Initiative on Brain Barriers and Drug Delivery, Scherfigsvej 7, 2100, Copenhagen, Denmark., Siupka P; Department of Biomedicine, Faculty of Health, Aarhus University, Ole Worms Allé 3, 8000, Aarhus, Denmark.; Lundbeck Foundation, Research Initiative on Brain Barriers and Drug Delivery, Scherfigsvej 7, 2100, Copenhagen, Denmark., P Augustine TJ; Research Program for Molecular Neurology, Helsinki University, Haartmaninkatu 8, 00290, Helsinki, Finland., Venø ST; Department of Biomedicine, Faculty of Health, Aarhus University, Ole Worms Allé 3, 8000, Aarhus, Denmark.; Lundbeck Foundation, Research Initiative on Brain Barriers and Drug Delivery, Scherfigsvej 7, 2100, Copenhagen, Denmark., Thomsen LB; Lundbeck Foundation, Research Initiative on Brain Barriers and Drug Delivery, Scherfigsvej 7, 2100, Copenhagen, Denmark.; Laboratory of Neurobiology, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 3, 9220, Aalborg, Denmark., Moos T; Lundbeck Foundation, Research Initiative on Brain Barriers and Drug Delivery, Scherfigsvej 7, 2100, Copenhagen, Denmark.; Laboratory of Neurobiology, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 3, 9220, Aalborg, Denmark., Lohi HT; Research Program for Molecular Neurology, Helsinki University, Haartmaninkatu 8, 00290, Helsinki, Finland., Madsen P; Department of Biomedicine, Faculty of Health, Aarhus University, Ole Worms Allé 3, 8000, Aarhus, Denmark., Lykke-Hartmann K; Department of Biomedicine, Faculty of Health, Aarhus University, Ole Worms Allé 3, 8000, Aarhus, Denmark.; Department of Clinical Genetics, Aarhus University Hospital, Brendstrupgårdsvej 21, 8200, Aarhus, Denmark.; Department of Clinical Medicine, Faculty of Health, Aarhus University, Bartholins Alle 6, 8000, Aarhus, Denmark., Nielsen MS; Department of Biomedicine, Faculty of Health, Aarhus University, Ole Worms Allé 3, 8000, Aarhus, Denmark. mn@biomed.au.dk.; Lundbeck Foundation, Research Initiative on Brain Barriers and Drug Delivery, Scherfigsvej 7, 2100, Copenhagen, Denmark. mn@biomed.au.dk.

Publikováno v: Molecular neurobiology [Mol Neurobiol] 2018 Nov; Vol. 55 (11), pp. 8522-8537. Date of Electronic Publication: 2018 Mar 20.