Výsledky vyhledávání - "Toshiyuki Yoneda"

Akademický článek

The lactate sensor GPR81 regulates glycolysis and tumor growth of breast cancer

Autor: Shota Ishihara, Kenji Hata, Katsutoshi Hirose, Tatsuo Okui, Satoru Toyosawa, Narikazu Uzawa, Riko Nishimura, Toshiyuki Yoneda

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)

Abstract Metabolic reprogramming is a malignant phenotype of cancer. Cancer cells utilize glycolysis to fuel rapid proliferation even in the presence of oxygen, and elevated glycolysis is coupled to lactate fermentation in the cancer microenvironment

Externí odkaz: https://doaj.org/article/cfb73f1b70b14fa58f27af5a6bfb900e

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2

Autor: Koichiro Ono, Kenji Hata, Eriko Nakamura, Shota Ishihara, Sachi Kobayashi, Masako Nakanishi, Michiko Yoshida, Yoshifumi Takahata, Tomohiko Murakami, Seiichi Takenoshita, Toshihisa Komori, Riko Nishimura, Toshiyuki Yoneda

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)

Koichiro Ono et al. report that Dmrt2 is a critical transcription factor for chondrocyte maturation during endochondral ossification. The study shows that Dmrt2 is the direct target of Sox9 and acts as a transcriptional coactivator of Runx2 providing

Externí odkaz: https://doaj.org/article/ea57b097864a4a5aa98c9580d3f4f6a3

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Sensory nerves: A driver of the vicious cycle in bone metastasis?

Autor: Toshiyuki Yoneda, Masahiro Hiasa, Tatsuo Okui, Kenji Hata

Publikováno v: Journal of Bone Oncology, Vol 30, Iss , Pp 100387- (2021)

Bone is one of the preferential target organs of cancer metastasis. Bone metastasis is associated with various complications, of which bone pain is most common and debilitating. The cancer-associated bone pain (CABP) is induced as a consequence of in

Externí odkaz: https://doaj.org/article/8fb4701042514ad0a5cd59ee0ca81d3e

Zobrazit plný text záznamu

Akademický článek

Japanese Expert Panel Meeting on the Management of Prostate Cancer with Bone Metastases

Publikováno v: Oncology and Therapy, Vol 6, Iss 2, Pp 157-171 (2018)

Abstract Introduction The incidence of prostate cancer in Japan continues to increase, necessitating the continued development of effective therapies and strategies. Recent advances in treatments have improved the prognosis of metastatic disease and

Externí odkaz: https://doaj.org/article/39f60399f876455299e1113900fc8ff0

Zobrazit plný text záznamu

Akademický článek

The HMGB1/RAGE axis induces bone pain associated with colonization of 4T1 mouse breast cancer in bone

Autor: Tatsuo Okui, Masahiro Hiasa, Shoji Ryumon, Kisho Ono, Yuki Kunisada, Soichiro Ibaragi, Akira Sasaki, G. David Roodman, Fletcher A. White, Toshiyuki Yoneda

Publikováno v: Journal of Bone Oncology, Vol 26, Iss , Pp 100330- (2021)

Bone pain is a common complication of breast cancer (BC) bone metastasis and is a major cause of increased morbidity and mortality. Although the mechanism of BC-associated bone pain (BCABP) remains poorly understood, involvement of BC products in the

Externí odkaz: https://doaj.org/article/feab4f9e534e44f0a0d928b0f0cc2144

Zobrazit plný text záznamu

Akademický článek

Identifying the preferable rheumatoid arthritis subgroups for intervention with the anti-RANKL antibody denosumab to reduce progression of joint destruction

Autor: Désirée van der Heijde, Tsutomu Takeuchi, Yoshiya Tanaka, Hisashi Yamanaka, Satoshi Soen, Toshiyuki Yoneda, Sakae Tanaka, Takaya Nitta, Naoki Okubo, Naoki Ishiguro, Takeshi Ohira, Harry Genant

Publikováno v: RMD Open, Vol 6, Iss 2 (2020)

Objectives To clarify which rheumatoid arthritis (RA) patients benefit most from the anti-receptor activator of nuclear factor-κB ligand antibody denosumab to reduce the progression of joint destruction.Methods We pooled patient data from the 12-mon

Externí odkaz: https://doaj.org/article/daabaeb77bd14d7884e5eb30d20b465e

Zobrazit plný text záznamu

Akademický článek

The SK-N-AS human neuroblastoma cell line develops osteolytic bone metastases with increased angiogenesis and COX-2 expression

Autor: Takahiro Tsutsumimoto, Paul Williams, Toshiyuki Yoneda

Publikováno v: Journal of Bone Oncology, Vol 3, Iss 3, Pp 67-76 (2014)

Neuroblastoma (NB), which arises from embryonic neural crest cells, is the most common extra-cranial solid tumor of childhood. Approximately half of NB patients manifest bone metastasis accompanied with bone pain, fractures and bone marrow failure, l

Externí odkaz: https://doaj.org/article/4820cbce5902443b92d48b3caef46948

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání