Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Toshiyuki Tsukaguchi"'
Autor:
Masahiro Aoki, Nobuya Ishii, Yasuko Satoh, Toshihiko Fujii, Toshiyuki Tsukaguchi, Nukinori Akiyama, Yoshito Nakanishi
Recent cancer genome profiling studies have identified many novel genetic alterations, including rearrangements of genes encoding FGFR family members. However, most fusion genes are not functionally characterized, and their potentials in targeted the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca22b26ce6e3e9a352ffd8a3e7f4b9ac
https://doi.org/10.1158/1535-7163.c.6536803.v1
https://doi.org/10.1158/1535-7163.c.6536803.v1
Autor:
Toshiyuki Mio, Nobuhiro Oikawa, Yoshiyuki Ono, Kiyoshi Hasegawa, Atsuko Higashida, Kenji Takanashi, Yukako Tachibana, Toshihiko Fujii, Kiyoaki Sakata, Miyuki Yoshida, Hiromi Tanimura, Masami Hasegawa, Toshiyuki Tsukaguchi, Hitoshi Sase, Hiroshi Tanaka
Members of the tropomyosin receptor kinase (TRK) family are expressed in their constitutively activated forms as a result of a gene fusion that occurs across a wide variety of cancer types. We have identified CH7057288 as a potent and selective TRK i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfa93b96927a6877a3f05c4196107dc2
https://doi.org/10.1158/1535-7163.c.6537879.v1
https://doi.org/10.1158/1535-7163.c.6537879.v1
Autor:
Masahiro Aoki, Nobuya Ishii, Yasuko Satoh, Toshihiko Fujii, Toshiyuki Tsukaguchi, Nukinori Akiyama, Yoshito Nakanishi
Gene signature of FGFR3-BAIAP2L1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34cd505bad97f19033cd4daaf997bd8c
https://doi.org/10.1158/1535-7163.22501492.v1
https://doi.org/10.1158/1535-7163.22501492.v1
Autor:
Masahiro Aoki, Nobuya Ishii, Yasuko Satoh, Toshihiko Fujii, Toshiyuki Tsukaguchi, Nukinori Akiyama, Yoshito Nakanishi
Pathway analysis of FGFR3-BAIAP2L1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab92914def57b57a899b90f333e57370
https://doi.org/10.1158/1535-7163.22501513.v1
https://doi.org/10.1158/1535-7163.22501513.v1
Autor:
Toshiyuki Mio, Nobuhiro Oikawa, Yoshiyuki Ono, Kiyoshi Hasegawa, Atsuko Higashida, Kenji Takanashi, Yukako Tachibana, Toshihiko Fujii, Kiyoaki Sakata, Miyuki Yoshida, Hiromi Tanimura, Masami Hasegawa, Toshiyuki Tsukaguchi, Hitoshi Sase, Hiroshi Tanaka
Figure S1. Chemical structure, Figure S2. Kinase selectivity, Figure S3. PK, Figure S4. Inhibition of proliferation and induction of apoptosis in vivo, Figure S5. TP53 sequencing, Table S2. Crystallographic data collection, Table S3. Genes changed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532037d80c5ba0c7ef960e1800880011
https://doi.org/10.1158/1535-7163.22504872
https://doi.org/10.1158/1535-7163.22504872
Autor:
Masahiro Aoki, Nobuya Ishii, Yasuko Satoh, Toshihiko Fujii, Toshiyuki Tsukaguchi, Nukinori Akiyama, Yoshito Nakanishi
Supplementary materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547240e15914a3f217f8e068791d3d56
https://doi.org/10.1158/1535-7163.22501489
https://doi.org/10.1158/1535-7163.22501489
Autor:
Hiroshi Sakamoto, Osamu Kondoh, Yoshiaki Watanabe, Miyuki Yoshida, Yasuko Satoh, Toshiyuki Tsukaguchi, Tatsushi Kodama
Supplementary Figures S1-S5. Figure S1: Kinase selectivity of alectinib, vandetanib, cabozantinib, sorafenib, sunitinib, and ponatinib against several kinases including RET. Figure S2: Effect of crizotinib or LDK378 against Ba/F3 cells expressing KIF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ee0f9f29687f483c70e880c01eb97d
https://doi.org/10.1158/1535-7163.22502463.v1
https://doi.org/10.1158/1535-7163.22502463.v1
Autor:
Toshiyuki Mio, Nobuhiro Oikawa, Yoshiyuki Ono, Kiyoshi Hasegawa, Atsuko Higashida, Kenji Takanashi, Yukako Tachibana, Toshihiko Fujii, Kiyoaki Sakata, Miyuki Yoshida, Hiromi Tanimura, Masami Hasegawa, Toshiyuki Tsukaguchi, Hitoshi Sase, Hiroshi Tanaka
Cell line information and sensitivity to CH7057288 in high-throughput assay systems.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a35d417f0e205af5dc4491844a23fe55
https://doi.org/10.1158/1535-7163.22504869
https://doi.org/10.1158/1535-7163.22504869
Autor:
Nobuya Ishii, Yuko Aoki, Naoki Taka, Hirosato Ebiike, Toshiyuki Mio, Hidetoshi Shindoh, Kenji Morikami, Takehito Isobe, Hitoshi Sase, Kiyoaki Sakata, Toshihiko Fujii, Toshiyuki Tsukaguchi, Nukinori Akiyama, Yoshito Nakanishi
Supplementary Materials and Methods from The Fibroblast Growth Factor Receptor Genetic Status as a Potential Predictor of the Sensitivity to CH5183284/Debio 1347, a Novel Selective FGFR Inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01026f8d65f8ae2359cbbdaf1c7f8e2
https://doi.org/10.1158/1535-7163.22501813
https://doi.org/10.1158/1535-7163.22501813
Autor:
Nobuya Ishii, Yuko Aoki, Naoki Taka, Hirosato Ebiike, Toshiyuki Mio, Hidetoshi Shindoh, Kenji Morikami, Takehito Isobe, Hitoshi Sase, Kiyoaki Sakata, Toshihiko Fujii, Toshiyuki Tsukaguchi, Nukinori Akiyama, Yoshito Nakanishi
Supplementary Figures S1-S7 and Table. S1: Determination of the binding mode of the FGFR inhibitor CH5183284/Debio 1347. S2: Effects of CH5183284/Debio 1347 and cediranib on in vitro VEGF-induced tube formation. S3: Kinase activity of FGFR2 WT, V564F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7730b1607e611f614d761c364343ce4c
https://doi.org/10.1158/1535-7163.22501816.v1
https://doi.org/10.1158/1535-7163.22501816.v1