Zobrazeno 1 - 10
of 277
pro vyhledávání: '"Toshiyuki Sakaeda"'
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 203 (2022)
This study was conducted to evaluate the long-term plasma concentration profiles of dapagliflozin and its effects on the glycated hemoglobin (HbA1c) level, body weight, and estimated glomerular filtration rate (eGFR) in 72 Japanese outpatients with t
Externí odkaz:
https://doaj.org/article/ee53ec6d8c4d4daf96507c309f1d0539
Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1.
Autor:
Yutaka Takaoka, Atsuko Takeuchi, Aki Sugano, Kenji Miura, Mika Ohta, Takashi Suzuki, Daisuke Kobayashi, Takuji Kimura, Juichi Sato, Nobutaro Ban, Hisahide Nishio, Toshiyuki Sakaeda
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225244 (2019)
UDP-glucuronosyltransferase 1A1 (UGT1A1) is an enzyme that is found in the endoplasmic reticulum membrane and can reportedly have a large number of amino acid substitutions that result in the reduction of glucuronidation capacity. For example, advers
Externí odkaz:
https://doaj.org/article/5c987badd56346a1b30ffdc27ddf910c
Publikováno v:
Antibiotics, Vol 9, Iss 4, p 199 (2020)
Recent research has found higher levels and longer total exposure of azithromycin, a macrolide antibiotic agent, in the interstitial fluid of the skin than in the plasma. This unique distribution is expected to contribute to its antimicrobial activit
Externí odkaz:
https://doaj.org/article/8216a7bc1e354a78a3583f0cb2d15f00
Publikováno v:
International Journal of Medical Sciences, Vol 8, Iss 6, Pp 487-491 (2011)
Objective: Adverse event reports (AERs) submitted to the US Food and Drug Administration (FDA) were reviewed to confirm platinum agent-associated adverse events, and to clarify the rank-order of these drugs in terms of susceptibility.Methods: After a
Externí odkaz:
https://doaj.org/article/fab6f7179b534349860f4c4f2b544a9d
Publikováno v:
International Journal of Medical Sciences, Vol 8, Iss 4, Pp 332-338 (2011)
Objective: Adverse event reports (AERs) submitted to the US Food and Drug Administration (FDA) were reviewed to confirm the platinum agent-associated mild, severe, and lethal hypersensitivity reactions.Methods: Authorized pharmacovigilance tools were
Externí odkaz:
https://doaj.org/article/cc542d266eb74db3a64d677be7de45a9
Autor:
Tatsurou Yagami, Yukio Takahara, Chiyomi Ishibashi, Gaku Sakaguchi, Naohiro Itoh, Keiichi Ueda, Hitoshi Nakazato, Noboru Okamura, Yoshiharu Hiramatsu, Tsunetoshi Honma, Akinori Arimura, Toshiyuki Sakaeda, Goro Katsuura
Publikováno v:
Neurobiology of Disease, Vol 16, Iss 3, Pp 481-489 (2004)
Amyloid β protein (Aβ) deposits are found in the striatum of patients with Alzheimer disease (AD) showing extrapyramidal motor dysfunction, but neuronal cell loss has not yet been detected. To clarify how Aβ impairs motor function, we analyzed int
Externí odkaz:
https://doaj.org/article/31a42d5b18564294b052118ae1be4f94
Autor:
Ayano Inoba, Kaori Kadoyama, Keiko Minami, Akiko Tamon, Masahiro Tsuda, Toshiyuki Sakaeda, Yasushi Okuno
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 11, Iss 1, Pp 140-141 (2016)
Externí odkaz:
https://doaj.org/article/ee220db40ca94a5c9faeb105feabf521
Autor:
Yasuhiro Yamamoto, Kenkichi Takase, Junji Kishino, Megumi Fujita, Noboru Okamura, Toshiyuki Sakaeda, Masafumi Fujimoto, Tatsurou Yagami
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17552 (2011)
15-deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)) is one of factors contributed to the neurotoxicity of amyloid β (Aβ), a causative protein of Alzheimer's disease. Type 2 receptor for prostaglandin D(2) (DP2) and peroxysome-proliferator activated
Externí odkaz:
https://doaj.org/article/719813be86c243dab0ba9827cd761198
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28124 (2011)
OBJECTIVE: Adverse event reports (AERs) submitted to the US Food and Drug Administration (FDA) were reviewed to assess the muscular and renal adverse events induced by the administration of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase in
Externí odkaz:
https://doaj.org/article/14976299349244cc9a7a53cbbf821016
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18141 (2011)
Heat shock proteins (Hsp) are a family of stress-inducible molecular chaperones that play multiple roles in a wide variety of animals. However, the roles of Hsps in parasitic nematodes remain largely unknown. To elucidate the roles of Hsps in the sur
Externí odkaz:
https://doaj.org/article/f00a200e11a946709ed5e555bdf8ab50