Zobrazeno 1 - 10 of 246 pro vyhledávání: '"Toshiyuki SAKAKI"'
1
Akademický článek
Gene therapy for alopecia in type II rickets model rats using vitamin D receptor-expressing adenovirus vector
Autor: Satoko Kise, Ayano Iijima, Chika Nagao, Tadashi Okada, Miyu Nishikawa, Shinichi Ikushiro, Tomoko Nakanishi, Shigeto Sato, Kaori Yasuda, Toshiyuki Sakaki
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Type II rickets is a hereditary disease caused by a mutation in the vitamin D receptor (VDR) gene. The main symptoms of this disease are bone dysplasia and alopecia. Bone dysplasia can be ameliorated by high calcium intake; however, there is
Externí odkaz: https://doaj.org/article/ff036fc97d624357a3c28fab11ccd90d
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2
Akademický článek
Robust osteogenic efficacy of 2α-heteroarylalkyl vitamin D analogue AH-1 in VDR (R270L) hereditary vitamin D-dependent rickets model rats
Autor: Miyu Nishikawa, Naruhiro Murose, Hiroki Mano, Kaori Yasuda, Yasuhiro Isogai, Atsushi Kittaka, Masashi Takano, Shinichi Ikushiro, Toshiyuki Sakaki
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Active vitamin D form 1α,25-dihydroxtvitamin D3 (1,25(OH)2D3) plays pivotal roles in calcium homeostasis and osteogenesis via its transcription regulation effect via binding to vitamin D receptor (VDR). Mutated VDR often causes hereditary v
Externí odkaz: https://doaj.org/article/2b3ef7c02bbe4b7293d7104a7bf1433b
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3
Akademický článek
Characterization of Rickets Type II Model Rats to Reveal Functions of Vitamin D and Vitamin D Receptor
Autor: Yuichiro Iwai, Ayano Iijima, Satoko Kise, Chika Nagao, Yuto Senda, Kana Yabu, Hiroki Mano, Miyu Nishikawa, Shinichi Ikushiro, Kaori Yasuda, Toshiyuki Sakaki
Publikováno v: Biomolecules, Vol 13, Iss 11, p 1666 (2023)
Vitamin D has been known to exert a wide range of physiological effects, including calcemic, osteogenic, anticancer, and immune responses. We previously generated genetically modified (GM) rats and performed a comparative analysis of their physiologi
Externí odkaz: https://doaj.org/article/e749c0be2c0c4e7db9e49c2f8585cda7
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4
Akademický článek
Differential Metabolic Stability of 4α,25- and 4β,25-Dihydroxyvitamin D3 and Identification of Their Metabolites
Autor: Yuka Mizumoto, Ryota Sakamoto, Kazuto Iijima, Naoto Nakaya, Minami Odagi, Masayuki Tera, Takatsugu Hirokawa, Toshiyuki Sakaki, Kaori Yasuda, Kazuo Nagasawa
Publikováno v: Biomolecules, Vol 13, Iss 7, p 1036 (2023)
Vitamin D3 (1) is metabolized by various cytochrome P450 (CYP) enzymes, resulting in the formation of diverse metabolites. Among them, 4α,25-dihydroxyvitamin D3 (6a) and 4β,25-dihydroxyvitamin D3 (6b) are both produced from 25-hydroxyvitamin D3 (2)
Externí odkaz: https://doaj.org/article/c5b86fd457e040e49e31682f095f8413
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6
Akademický článek
The First Convergent Synthesis of 23,23-Difluoro-25-hydroxyvitamin D3 and Its 24-Hydroxy Derivatives: Preliminary Assessment of Biological Activities
Autor: Sayuri Mototani, Fumihiro Kawagoe, Kaori Yasuda, Hiroki Mano, Toshiyuki Sakaki, Atsushi Kittaka
Publikováno v: Molecules, Vol 27, Iss 16, p 5352 (2022)
In this paper, we report an efficient synthetic route for the 23,23-difluoro-25-hydroxyvitamin D3 (5) and its 24-hydroxylated analogues (7,8), which are candidates for the CYP24A1 main metabolites of 5. The key fragments, 23,23-difluoro-CD-ring precu
Externí odkaz: https://doaj.org/article/3fe0d8b40b954d64881c01047bf1b804
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7
Akademický článek
Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice.
Autor: Yoshihisa Hirota, Kimie Nakagawa, Keigo Isomoto, Toshiyuki Sakaki, Noboru Kubodera, Maya Kamao, Naomi Osakabe, Yoshitomo Suhara, Toshio Okano
Publikováno v: PLoS ONE, Vol 13, Iss 10, p e0199856 (2018)
Calcium (Ca) absorption from the intestinal tract is promoted by active vitamin D (1α,25D3). Vitamin D not only promotes Ca homeostasis, but it also inhibits bone resorption and promotes osteogenesis, thus playing a role in the maintenance of normal
Externí odkaz: https://doaj.org/article/50be2928bad14f6d810ba5b6e8da038f
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8
Akademický článek
Avian cytochrome P450 (CYP) 1-3 family genes: isoforms, evolutionary relationships, and mRNA expression in chicken liver.
Autor: Kensuke P Watanabe, Yusuke K Kawai, Yoshinori Ikenaka, Minami Kawata, Shin-Ichi Ikushiro, Toshiyuki Sakaki, Mayumi Ishizuka
Publikováno v: PLoS ONE, Vol 8, Iss 9, p e75689 (2013)
Cytochrome P450 (CYP) of chicken and other avian species have been studied primarily with microsomes or characterized by cloning and protein expression. However, the overall existing isoforms in avian CYP1-3 families or dominant isoforms in avian xen
Externí odkaz: https://doaj.org/article/40d55cf1d7e64c159e4b5de179711cee
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10
Comparison of metabolism and biological properties among positional isomers of quercetin glucuronide in LPS- and RANKL-challenged RAW264.7 cells
Autor: Miyu, Nishikawa, Yuriko, Kada, Mirai, Kimata, Toshiyuki, Sakaki, Shinichi, Ikushiro
Publikováno v: Bioscience, Biotechnology, and Biochemistry. 86:1670-1679
The major quercetin metabolite, quercetin-3-glucuronide, exerts various biological activities, including anti-inflammatory effects. This study aimed to evaluate the metabolic profiles and biological properties of the positional isomers of quercetin m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dae968db04b8f2501af523d049e4eb5
https://doi.org/10.1093/bbb/zbac150
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