Zobrazeno 1 - 10
of 333
pro vyhledávání: '"Toshiyuki SAKAKI"'
Autor:
Satoko Kise, Ayano Iijima, Chika Nagao, Tadashi Okada, Miyu Nishikawa, Shinichi Ikushiro, Tomoko Nakanishi, Shigeto Sato, Kaori Yasuda, Toshiyuki Sakaki
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Type II rickets is a hereditary disease caused by a mutation in the vitamin D receptor (VDR) gene. The main symptoms of this disease are bone dysplasia and alopecia. Bone dysplasia can be ameliorated by high calcium intake; however, there is
Externí odkaz:
https://doaj.org/article/ff036fc97d624357a3c28fab11ccd90d
Autor:
Miyu Nishikawa, Naruhiro Murose, Hiroki Mano, Kaori Yasuda, Yasuhiro Isogai, Atsushi Kittaka, Masashi Takano, Shinichi Ikushiro, Toshiyuki Sakaki
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Active vitamin D form 1α,25-dihydroxtvitamin D3 (1,25(OH)2D3) plays pivotal roles in calcium homeostasis and osteogenesis via its transcription regulation effect via binding to vitamin D receptor (VDR). Mutated VDR often causes hereditary v
Externí odkaz:
https://doaj.org/article/2b3ef7c02bbe4b7293d7104a7bf1433b
Autor:
Yuichiro Iwai, Ayano Iijima, Satoko Kise, Chika Nagao, Yuto Senda, Kana Yabu, Hiroki Mano, Miyu Nishikawa, Shinichi Ikushiro, Kaori Yasuda, Toshiyuki Sakaki
Publikováno v:
Biomolecules, Vol 13, Iss 11, p 1666 (2023)
Vitamin D has been known to exert a wide range of physiological effects, including calcemic, osteogenic, anticancer, and immune responses. We previously generated genetically modified (GM) rats and performed a comparative analysis of their physiologi
Externí odkaz:
https://doaj.org/article/e749c0be2c0c4e7db9e49c2f8585cda7
Autor:
Yuka Mizumoto, Ryota Sakamoto, Kazuto Iijima, Naoto Nakaya, Minami Odagi, Masayuki Tera, Takatsugu Hirokawa, Toshiyuki Sakaki, Kaori Yasuda, Kazuo Nagasawa
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1036 (2023)
Vitamin D3 (1) is metabolized by various cytochrome P450 (CYP) enzymes, resulting in the formation of diverse metabolites. Among them, 4α,25-dihydroxyvitamin D3 (6a) and 4β,25-dihydroxyvitamin D3 (6b) are both produced from 25-hydroxyvitamin D3 (2)
Externí odkaz:
https://doaj.org/article/c5b86fd457e040e49e31682f095f8413
Autor:
Fumihiro Kawagoe, Kaori Yasuda, Sayuri Mototani, Toru Sugiyama, Motonari Uesugi, Toshiyuki Sakaki, Atsushi Kittaka
Publikováno v:
ACS Omega, Vol 4, Iss 6, Pp 11332-11337 (2019)
Externí odkaz:
https://doaj.org/article/2c9112394dd8460db46e56762c130f84
Autor:
Sayuri Mototani, Fumihiro Kawagoe, Kaori Yasuda, Hiroki Mano, Toshiyuki Sakaki, Atsushi Kittaka
Publikováno v:
Molecules, Vol 27, Iss 16, p 5352 (2022)
In this paper, we report an efficient synthetic route for the 23,23-difluoro-25-hydroxyvitamin D3 (5) and its 24-hydroxylated analogues (7,8), which are candidates for the CYP24A1 main metabolites of 5. The key fragments, 23,23-difluoro-CD-ring precu
Externí odkaz:
https://doaj.org/article/3fe0d8b40b954d64881c01047bf1b804
Autor:
Chika NAGAO, Satoko KISE, Ayano IIJIMA, Tadashi OKADA, Tomoko NAKANISHI, Shigeto SATO, Miyu NISHIKAWA, Shinchi IKUSHIRO, Kaori YASUDA, Toshiyuki SAKAKI
Publikováno v:
Journal of Nutritional Science and Vitaminology. 69:90-97
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::494bd37790327d9f818fe793f0ccbdc6
https://doi.org/10.3177/jnsv.69.90
https://doi.org/10.3177/jnsv.69.90
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 86:1670-1679
The major quercetin metabolite, quercetin-3-glucuronide, exerts various biological activities, including anti-inflammatory effects. This study aimed to evaluate the metabolic profiles and biological properties of the positional isomers of quercetin m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dae968db04b8f2501af523d049e4eb5
https://doi.org/10.1093/bbb/zbac150
https://doi.org/10.1093/bbb/zbac150
Autor:
Nagasawa, Yuka Mizumoto, Ryota Sakamoto, Kazuto Iijima, Naoto Nakaya, Minami Odagi, Masayuki Tera, Takatsugu Hirokawa, Toshiyuki Sakaki, Kaori Yasuda, Kazuo
Publikováno v:
Biomolecules; Volume 13; Issue 7; Pages: 1036
Vitamin D3 (1) is metabolized by various cytochrome P450 (CYP) enzymes, resulting in the formation of diverse metabolites. Among them, 4α,25-dihydroxyvitamin D3 (6a) and 4β,25-dihydroxyvitamin D3 (6b) are both produced from 25-hydroxyvitamin D3 (2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::5b41600fbfbc40f9408efe9cde95ea9a
Autor:
Teisuke, Takita, Hiro, Sakuma, Ren, Ohashi, Somaye, Nilouyal, Sho, Nemoto, Moeka, Wada, Yuya, Yogo, Kaori, Yasuda, Shinichi, Ikushiro, Toshiyuki, Sakaki, Kiyoshi, Yasukawa
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 86:444-454
CYP105A1 from Streptomyces griseolus converts vitamin D3 to its biologically active form, 1α,25-dihydroxy vitamin D3. R73A/R84A mutation enhanced the 1α- and 25-hydroxylation activity for vitamin D3, while M239A mutation generated the 1α-hydroxyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5138c930daa370e7a8a0d4f326e28f
https://doi.org/10.1093/bbb/zbac019
https://doi.org/10.1093/bbb/zbac019