Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Toshiyuki Negoro"'
Autor:
Makoto Murata, Kaori Kato, Chiaki Migihashi, Toshiyuki Negoro, Akihito Fujii, Futoshi Hasegawa, Takafumi Matsumoto, Kazumi Niidome
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4266-4270
Furan-2-carbohydrazides were found as orally active glucagon receptor antagonists. Starting from the hit compound 5, we successfully determined the structure activity relationships of a series of derivatives obtained by modifying the acidity of the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fee41960943ec3385b1effaab3ce6c1
https://doi.org/10.1016/j.bmcl.2014.07.025
https://doi.org/10.1016/j.bmcl.2014.07.025
Publikováno v:
Biochemical Pharmacology. 71:338-353
AS-3201 [(3R)-2'-(4-bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'(1'H)-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone] is a structurally novel and stereospecifically potent aldose reductase (AKR1B; EC 1.1.1.21) inhibitor, which contains a succinimide r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2dab3a43df0f29dc7c2dd175bcdf8c1
https://doi.org/10.1016/j.bcp.2005.10.036
https://doi.org/10.1016/j.bcp.2005.10.036
Autor:
Kenji Suzuki, Jun-Ichi Matsumoto, Makoto Murata, Toshiyuki Negoro, Yoshiyuki Ono, Buichi Fujitani, Akemi Kuromiya, Masanobu Komiya, Ueda Shozo
Publikováno v:
Journal of Medicinal Chemistry. 41:4118-4129
A series of novel tetrahydropyrrolo[1,2-a]pyrazine derivatives were synthesized and evaluated as aldose reductase inhibitors (ARIs) on the basis of their abilities to inhibit porcine lens aldose reductase (AR) in vitro and to inhibit sorbitol accumul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9528354190fd338af75d0f5c468a2e4
https://doi.org/10.1021/jm9802968
https://doi.org/10.1021/jm9802968
Autor:
Buichi Fujitani, Jun-Ichi Matsumoto, Makoto Murata, Toshiyuki Negoro, Akemi Kuromiya, Kenji Suzuki, Yoshiyuki Ono, Masanobu Komiya, Ueda Shozo
Publikováno v:
ChemInform. 30
A series of novel tetrahydropyrrolo[1,2-a]pyrazine derivatives were synthesized and evaluated as aldose reductase inhibitors (ARIs) on the basis of their abilities to inhibit porcine lens aldose reductase (AR) in vitro and to inhibit sorbitol accumul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::512bdb8cec62e9730ccb4f61dfdf1b3b
https://doi.org/10.1002/chin.199911179
https://doi.org/10.1002/chin.199911179
Publikováno v:
Journal of Medicinal Chemistry. 21:1265-1269
Forty-six 1-cycloalkyl-4-(1,2-diphenylethyl)piperazines were synthesized. The influence of substituents on phenyl groups of 1-cycloalkyl-4-(1,2-diphenylethyl)piperazines 4a-c on the analgesic activity was investigated in experimental animals. The mos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ffe3ee796845d3547ea2a6d9b3ff1b1
https://doi.org/10.1021/jm00210a017
https://doi.org/10.1021/jm00210a017
Autor:
Yutaka Sekine, Shoko Ishikawa, Toshiyuki Negoro, Sachiko Oida, Akira Kagemoto, Yoshiaki Terauchi
Publikováno v:
Journal of Pharmacobio-Dynamics. 11:459-464
A sensitive and specific radioimmunoassay has been developed for the determination of L-6-keto-piperidine-2-carbonyl-L-leucyl-L-proline amide (RGH-2202), a new analog of thyrotropin-releasing hormone (TRH), in plasma. An antiserum was produced in gui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345c3ebefc5772d67c9a242af53ed421
https://doi.org/10.1248/bpb1978.11.459
https://doi.org/10.1248/bpb1978.11.459
Autor:
Keiichi Tanaka, Naoko Mikuriya, Masahisa Hashimoto, Hisashi Miyazaki, Toshihiko Fujii, Akira Kagemoto, Toshiyuki Negoro, Yutaka Sekine, Hideo Furukawa
Publikováno v:
Drug Metabolism and Pharmacokinetics. 2:587-603
Absorption, distribution, excretion and metabolism of [14C]cadralazine were studied in rats after 10 consecutive daily oral administration at the dose of 3 mg/kg. 1. Plasma levels at 1 hr after each administration were around 1 μg eq./ml. Levels aft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6222bb7c59c839cd24317d29486d8bbe
https://doi.org/10.2133/dmpk.2.587
https://doi.org/10.2133/dmpk.2.587
Autor:
Naoko Mikuriya, Keiichi Tanaka, Hisashi Miyazaki, Masahisa Hashimoto, Akira Kagemoto, Yutaka Sekine, Hideki Amejima, Toshihiko Fujii, Toshiyuki Negoro
Publikováno v:
Drug Metabolism and Pharmacokinetics. 2:613-624
For elucidation of common characteristics in disposition of hydralazine vasodilators, distribution of [14C]hydralazine and [14C]budralazine was studied in normal rats at the time points of their maximal tissue levels and at 24 hr after single and 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f3185318030b7442dac8d7ea04ba175
https://doi.org/10.2133/dmpk.2.613
https://doi.org/10.2133/dmpk.2.613
Autor:
Akira Kagemoto, Midori Miki, Tadao Maeda, Hirosato Suzuki, Toshiyuki Negoro, Yutaka Sekine, Masahisa Mashimoto
Publikováno v:
Journal of pharmacobio-dynamics. 4(3)
radioimmunoassays have been developed which enable accurate and sensitive determination of gliclazide in human serum. Antisera A and B against gliclazide were obtained from guinea pigs immunized with conjugates A and B prepared by coupling gliclazide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38f487feae7a14236c900fecbc1fcae
https://pubmed.ncbi.nlm.nih.gov/7252771
https://pubmed.ncbi.nlm.nih.gov/7252771
Autor:
Toshiyuki Negoro, Hitoshi Uno, Haruki Nishimura, Yoshinori Nishikawa, Kagayaki Natsuka, Hideo Nakamura
Publikováno v:
Journal of medicinal chemistry. 30(10)
Racemates and enantiomers of 1-substituted 4-[2-(3-hydroxyphenyl)-1-phenylethyl]piperazine derivatives (3-18) were synthesized, and their analgesic and other pharmacological activities and structure-activity relationships were investigated. The S-(+)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f505a08d4a757e2e90e216eeac4d62
https://pubmed.ncbi.nlm.nih.gov/3656354
https://pubmed.ncbi.nlm.nih.gov/3656354