Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Toshiyuki HONDA"'
Publikováno v:
BMC Research Notes, Vol 12, Iss 1, Pp 1-7 (2019)
Abstract Objective A dual inhibitor of focal adhesion kinase (FAK) and insulin-like growth factor 1 receptor (IGF-1R), TAE226, was evaluated in a panel of cancer cell lines, MIA PaCa-2 human pancreatic tumor and 4T1 murine breast tumor models. The pr
Externí odkaz:
https://doaj.org/article/f6300bd517b0413780d8f644353baa66
Publikováno v:
Heliyon, Vol 5, Iss 11, Pp e02849- (2019)
Objective: To identify an agonist of RXRα and RARα with reduced undesired profiles of all-trans retinoic acid for differentiation-inducing therapy of acute promyelocytic leukemia (APL), such as its susceptibility to P450 enzyme, induction of P450 e
Externí odkaz:
https://doaj.org/article/dfe66de0792548d89b02eec6cb744bbd
Publikováno v:
Nihon Kikai Gakkai ronbunshu, Vol 82, Iss 842, Pp 16-00294-16-00294 (2016)
Forklift trucks, a typical distribution vehicle, have a vibration problem in the vertical direction between 2 and 3 Hz, which is induced by surface roughness of the road. This vibration reduces not only the comfort of the operator, but also the distr
Externí odkaz:
https://doaj.org/article/a663421e694e4193813d0099afc0c78c
Autor:
Iain M. Wallace, Hyun-Hee Cho, Pramod Pandey, Soo-Hee Park, Allison Fedolak, Dechristopher Brian Addison, Christopher Hogan, Olga Rozhitskaya, Derek Bamford, Liansheng Su, Toshiyuki Honda, Rohit Duvadie, Linh Vong, Elizabeth Tomlinson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:991-994
The relaxin family peptide receptors have been implicated in numerous physiological processes including energy homeostasis, cardiac function, wound healing, and reproductive function. Two family members, RXFP3 and RXFP4, are class A GPCRs with endoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418b6fe5324da9d6735f1f588262d09c
https://doi.org/10.1016/j.bmcl.2019.02.013
https://doi.org/10.1016/j.bmcl.2019.02.013
Publikováno v:
Heliyon
Heliyon, Vol 5, Iss 11, Pp e02849-(2019)
Heliyon, Vol 5, Iss 11, Pp e02849-(2019)
Objective To identify an agonist of RXRα and RARα with reduced undesired profiles of all-trans retinoic acid for differentiation-inducing therapy of acute promyelocytic leukemia (APL), such as its susceptibility to P450 enzyme, induction of P450 en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb82e52f3f36c0e08f0eee71e3d949a9
http://europepmc.org/articles/PMC6872757
http://europepmc.org/articles/PMC6872757
Autor:
Connie R. Bezzina, Sara Vandenwijngaert, Najim Lahrouchi, John L. Diener, Clara D. Ledsky, Daniel Bloch, Lisa Ames, Florian Wunderer, Toshiyuki Honda, Mohsin A.F. Khan, Christopher Newton-Cheh, Emmanuel S. Buys
Publikováno v:
Circulation. Genomic and precision medicine, 12(8). Lippincott Williams and Wilkins Ltd.
Background: Human genetic variation in the NPR1 (natriuretic peptide receptor 1 gene, encoding NPR-A, atrial natriuretic peptide receptor 1) was recently shown to affect blood pressure (BP). NPR-A catalyzes the intracellular conversion of guanosine t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e41c5662cca44172c9724a5a78783ed
https://pubmed.ncbi.nlm.nih.gov/31430210
https://pubmed.ncbi.nlm.nih.gov/31430210
Publikováno v:
BMC Research Notes
BMC Research Notes, Vol 12, Iss 1, Pp 1-7 (2019)
BMC Research Notes, Vol 12, Iss 1, Pp 1-7 (2019)
Objective A dual inhibitor of focal adhesion kinase (FAK) and insulin-like growth factor 1 receptor (IGF-1R), TAE226, was evaluated in a panel of cancer cell lines, MIA PaCa-2 human pancreatic tumor and 4T1 murine breast tumor models. The profiling d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8b9e17a5b801d86d731bdfbaf1b60f8
https://doi.org/10.1186/s13104-019-4389-7
https://doi.org/10.1186/s13104-019-4389-7
Publikováno v:
Transactions of the JSME (in Japanese). 82:16-00294
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::decfa653f42d38ca2c116f7124722df3
https://doi.org/10.1299/transjsme.16-00294
https://doi.org/10.1299/transjsme.16-00294
Autor:
Sally Loi, Lac Lee, Jean Regard, Dominique Custeau, Andrew Patterson, Lin Deng, Julien Papillon, Aimee Reynolds, Tyler Harrison, Micah Hollis-Symynkywicz, Jovita Marcinkeviciene, Lawrence G. Hamann, Anup Patnaik, Xianglin Ren, Jutta Blank, Nigel Casson, Laura Axford, Toshiyuki Honda, Lisa Ames, Lihe Zhang, Martin L. Marro
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 367(1)
Myeloperoxidase (MPO) is a leukocyte-derived redox enzyme that has been linked to oxidative stress and damage in many inflammatory states, including cardiovascular disease. We have discovered aminopyridines that are potent mechanism-based inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444de565ea988076b4b032134228dce7
https://pubmed.ncbi.nlm.nih.gov/30076263
https://pubmed.ncbi.nlm.nih.gov/30076263
Publikováno v:
Applied Physics B. 111:117-126
The localized enhanced near field on nanostructures has been attracting much attention for a template for size-selective optical trapping (tweezers) beyond the diffraction limit. The near-field optical trapping has mainly been studied using metallic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::491956afe251ecab4f1f19bff86ef95f
https://doi.org/10.1007/s00340-012-5314-0
https://doi.org/10.1007/s00340-012-5314-0