Zobrazeno 1 - 10
of 238
pro vyhledávání: '"Toshiyuki, Nomura"'
Synergistic apoptotic effects in cancer cells by the combination of CLK and Bcl-2 family inhibitors.
Autor:
Aiko Murai, Shunsuke Ebara, Satoshi Sasaki, Tomohiro Ohashi, Tohru Miyazaki, Toshiyuki Nomura, Shinsuke Araki
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240718 (2020)
Emerging evidence indicates that alternative splicing plays a critical role in cancer progression through abnormal expression or mutation of splicing factors. Small-molecule splicing modulators have recently attracted considerable attention as a nove
Externí odkaz:
https://doaj.org/article/d70071ab62df463cb60eee743a603d5b
Autor:
Ron de Jong, Takashi Satou, Bheema Paraselli, Charles Grimshaw, Yoshikazu Ohta, Mika Teratani, Toshiyuki Nomura, Seigo Ishino, BiChing Sang, Petro Halkowycz, Bumsup Lee, Robyn Fabrey, Sarah Elliott, Lilly Zhang, Takashi Hoshino, Deepika Balakrishna, Jennifer Matuszkiewicz, Lihong Shi, Pamela Farrell
PDF file - 56 KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d578afa59c63d95d6d60d9fb9d264df
https://doi.org/10.1158/1535-7163.22498837.v1
https://doi.org/10.1158/1535-7163.22498837.v1
Autor:
Ron de Jong, Takashi Satou, Bheema Paraselli, Charles Grimshaw, Yoshikazu Ohta, Mika Teratani, Toshiyuki Nomura, Seigo Ishino, BiChing Sang, Petro Halkowycz, Bumsup Lee, Robyn Fabrey, Sarah Elliott, Lilly Zhang, Takashi Hoshino, Deepika Balakrishna, Jennifer Matuszkiewicz, Lihong Shi, Pamela Farrell
PDF file - 3 MB, Quantitative cellular target profiling of TAK-901 using affinity chromatography.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76153b0135413183ebb9ffa88719414
https://doi.org/10.1158/1535-7163.22498843
https://doi.org/10.1158/1535-7163.22498843
Autor:
Tyler Funnell, Shinya Tasaki, Arusha Oloumi, Shinsuke Araki, Esther Kong, Damian Yap, Yusuke Nakayama, Christopher S. Hughes, S.-W. Grace Cheng, Hirokazu Tozaki, Misa Iwatani, Satoshi Sasaki, Tomohiro Ohashi, Tohru Miyazaki, Nao Morishita, Daisuke Morishita, Mari Ogasawara-Shimizu, Momoko Ohori, Shoichi Nakao, Masatoshi Karashima, Masaya Sano, Aiko Murai, Toshiyuki Nomura, Noriko Uchiyama, Tomohiro Kawamoto, Ryujiro Hara, Osamu Nakanishi, Karey Shumansky, Jamie Rosner, Adrian Wan, Steven McKinney, Gregg B. Morin, Atsushi Nakanishi, Sohrab Shah, Hiroyoshi Toyoshiba, Samuel Aparicio
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The phosphorylation of serine/arginine-rich proteins by CDC-like kinase is a central regulatory mechanism for RNA splicing reactions. Here, the authors synthesize a novel small molecule CLK inhibitor and map CLK-responsive alternative splicing events
Externí odkaz:
https://doaj.org/article/5aad2179e7e647afa20357dc81dea1bc
Autor:
Kazuhide Nakamura, Toshiyuki Nomura, Yusuke Kamada, Satoru Matsumoto, Shinji Iwasaki, Akio Mizutani, Yoshinori Ishikawa, Shinji Takagi
Supplementary Table 2: Genes commonly up-regulated or down-regulated by T-3775440 treatment in NCI-H1417, NCI-H510A, and NCI-526 cells. Supplementary Table 3: Plasma concentration and pharmacokinetic properties of T-3775440 in mice treated with a sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59aa0a4056e207801f097555a1fc50ee
https://doi.org/10.1158/0008-5472.22415366
https://doi.org/10.1158/0008-5472.22415366
Autor:
Kazuhide Nakamura, Toshiyuki Nomura, Yusuke Kamada, Satoru Matsumoto, Shinji Iwasaki, Akio Mizutani, Yoshinori Ishikawa, Shinji Takagi
T-3775440 is an irreversible inhibitor of the chromatin demethylase LSD1, which exerts antiproliferative effects by disrupting the interaction between LSD1 and GFI1B, a SNAG domain transcription factor, inducing leukemia cell transdifferentiation. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90a111c5411d840d2bd99bea697fc178
https://doi.org/10.1158/0008-5472.c.6509255.v1
https://doi.org/10.1158/0008-5472.c.6509255.v1
Autor:
Kazuhide Nakamura, Toshiyuki Nomura, Yusuke Kamada, Satoru Matsumoto, Shinji Iwasaki, Akio Mizutani, Yoshinori Ishikawa, Shinji Takagi
Supplementary Table S1: Genes up-regulated or down-regulated in H1417, H510A, or H526 cell line upon T-3775440 treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f8749323abfad61b414488e0825d90
https://doi.org/10.1158/0008-5472.22415369
https://doi.org/10.1158/0008-5472.22415369
Autor:
Hayato Tokumoto, Shizue Yoshihara, Kasumi Yamamoto, Yoshino Nakajima, Kana Ibuchi, Toshiyuki Nomura, Kensuke Kurahashi
Engineered ZnO nanoparticles exist in particle and ion states in aqueous solutions. This study was compared the exposure of different state Zn for lettuce seedlings as in vitro organ culture of root using lettuce seedlings for short time in petri dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a92e5c460888e015558dea29455e7dc
https://doi.org/10.21203/rs.3.rs-2635985/v1
https://doi.org/10.21203/rs.3.rs-2635985/v1
Autor:
Kenichi Iwai, Masahiro Yaguchi, Kazuho Nishimura, Yukiko Yamamoto, Toshiya Tamura, Daisuke Nakata, Ryo Dairiki, Yoichi Kawakita, Ryo Mizojiri, Yoshiteru Ito, Moriteru Asano, Hironobu Maezaki, Yusuke Nakayama, Misato Kaishima, Kozo Hayashi, Mika Teratani, Shuichi Miyakawa, Misa Iwatani, Maki Miyamoto, Michael G Klein, Wes Lane, Gyorgy Snell, Richard Tjhen, Xingyue He, Sai Pulukuri, Toshiyuki Nomura
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 6, Pp n/a-n/a (2018)
Abstract The modulation of pre‐mRNA splicing is proposed as an attractive anti‐neoplastic strategy, especially for the cancers that exhibit aberrant pre‐mRNA splicing. Here, we discovered that T‐025 functions as an orally available and potent
Externí odkaz:
https://doaj.org/article/5f979a579b0246ad90c5cfcded6e406d
Publikováno v:
2022 International Workshop on Acoustic Signal Enhancement (IWAENC).