Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Toshiyuki, Miyashita"'
Autor:
Kazuaki Nagao, Chise Kato, Yu Ikemoto, Toshino Motojima, Katsunori Fujii, Akihiro Umezawa, Toshiyuki Miyashita
Publikováno v:
Discover Oncology, Vol 13, Iss 1, Pp 1-12 (2022)
Abstract Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder with an increased incidence of tumors, such as basal cell carcinomas and medulloblastomas. The PTCH1 gene, responsible for NBCCS, suppresses the hedgehog signalin
Externí odkaz:
https://doaj.org/article/df180476f51e4bfcad68c3fcba2c1b10
Autor:
Ellen Toyonaga, Hiroo Hata, Chihiro Nakayama, Erina Homma, Toshiyuki Miyashita, Hiroshi Shimizu
Publikováno v:
Case Reports in Oncology, Vol 8, Iss 3, Pp 536-539 (2015)
Nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin syndrome, is a rare hereditary condition characterized by a wide range of developmental abnormalities and a predisposition to neoplasms. The syndrome consists of early-onset and/or mu
Externí odkaz:
https://doaj.org/article/59b7169acc1f49c98e230b3bf76387c0
Autor:
Atsushi Fukuda, Atsushi Mitani, Toshiyuki Miyashita, Takashi Sado, Akihiro Umezawa, Hidenori Akutsu
Publikováno v:
PLoS Genetics, Vol 12, Iss 10, p e1006375 (2016)
In female mammals, activation of Xist (X-inactive specific transcript) is essential for establishment of X chromosome inactivation. During early embryonic development in mice, paternal Xist is preferentially expressed whereas maternal Xist (Xm-Xist)
Externí odkaz:
https://doaj.org/article/67535ad785524be781ce2fe387356fc6
Autor:
Michiyo Nasu, Toshiyuki Miyashita, Katsunori Fujii, Hiromi Hatsuse, Masashi Toyoda, Yu Ikemoto, Toshino Motojima, Akihiro Umezawa, Kazuhiro Kajiwara
Publikováno v:
Aging (Albany NY)
Gorlin syndrome is a rare autosomal dominant hereditary disease with high incidence of tumors such as basal cell carcinoma and medulloblastoma. Disease-specific induced pluripotent stem cells (iPSCs) have now been used as a model to analyze disease p
Autor:
Akihiro Umezawa, Yu Ikemoto, Naoki Shimojo, Marina Nagamine, Katsunori Fujii, Hajime Ikehara, Toshiyuki Miyashita
Publikováno v:
Laboratory Investigation. 100:657-664
The hedgehog signaling pathway is a vital factor for embryonic development and stem cell maintenance. Dysregulation of its function results in tumor initiation and progression. The aim of this research was to establish a disease model of hedgehog-rel
Autor:
Toshiyuki Miyashita, Takashi Miyajima, Yoshikatsu Eto, Kazuaki Nagao, Hiroko Yanagisawa, Mohammad Arif Hossain
Publikováno v:
Molecular Genetics and Metabolism. 126:460-465
Lysosomes are an essential organ for cellular metabolism and play an important role in autophagy. We examined the association between methylation and autophagy in a severely affected female patient with Fabry disease, which is caused by mutation of t
Autor:
Naoki Shimojo, Toshiyuki Miyashita, Michiko Nakazato, Katsunori Fujii, Hideki Uchikawa, Eiji Shimizu, Tadashi Shiohama
Publikováno v:
Pediatrics international : official journal of the Japan Pediatric SocietyReferences. 63(2)
Background Nevoid basal cell carcinoma syndrome (NBCCS) is a neurocutaneous disease, characterized by tumorigenesis and developmental anomalies due to aberrant sonic hedgehog (Shh) signaling. Patients with NBCCS typically appear calm and carefree, su
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49926 (2012)
Glucocorticoid (GC) is a major therapeutic agent for the treatment of leukemia because of its ability to induce apoptosis in lymphoid cells. The mechanism causing apoptosis, however, is still controversial. Since the glucocorticoid receptor is a tran
Externí odkaz:
https://doaj.org/article/6e6bdda91bfe4e74a50be5e308ab23ce
Autor:
Hiromi Hatsuse, Hajime Ikehara, Yu Ikemoto, Mokuri Masuda, Kohzoh Kameyama, Toshiyuki Miyashita, Akihiro Umezawa, Masashi Toyoda, Katsunori Fujii, Chise Kato, Yoshinaga Takayama, Kazuaki Nagao, Kazuko Fujitani
Publikováno v:
Journal of Medical Genetics. 54:579-584
Background Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterised by developmental defects and tumorigenesis, such as medulloblastomas and basal cell carcinomas, caused by mutations of the patched-1 ( PTCH1 ) gen
Autor:
Hiromi Mizuochi, Hideki Uchikawa, Toshiyuki Miyashita, Naoki Shimojo, Tadashi Shiohama, Katsunori Fujii
Publikováno v:
American Journal of Medical Genetics Part A. 173:946-952
Brain morphology is tightly regulated by diverse signaling pathways. Hedgehog signaling is a candidate pathway considered responsible for regulating brain morphology. Nevoid basal cell carcinoma syndrome (NBCCS), caused by a PTCH1 mutation in the hed