Zobrazeno 1 - 10
of 308
pro vyhledávání: '"Toshiyuki, Ishiwata"'
Autor:
Yuta Doshida, Shinichi Hashimoto, Sadahiro Iwabuchi, Yuka Takino, Toshiyuki Ishiwata, Toshiro Aigaki, Akihito Ishigami
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Senescent cells are predicted to occur and increase in animal tissues with aging. However, senescent cells in the tissues of aged animals remain to be identified. We refer to the marker genes to identify senescent cells in tissues as “age-
Externí odkaz:
https://doaj.org/article/009d14185bfc41ad962180e357571467
Autor:
Yoko Itakura, Yasuko Hasegawa, Yurika Kikkawa, Yuina Murakami, Kosuke Sugiura, Chiaki Nagai-Okatani, Norihiko Sasaki, Mariko Umemura, Yuji Takahashi, Tohru Kimura, Atsushi Kuno, Toshiyuki Ishiwata, Masashi Toyoda
Publikováno v:
Regenerative Therapy, Vol 22, Iss , Pp 68-78 (2023)
Introduction: Heart failure is caused by various factors, making the underlying pathogenic mechanisms difficult to identify. Since cardiovascular disease tends to worsen over time, early diagnosis is key for treatment. In addition, understanding the
Externí odkaz:
https://doaj.org/article/b2bed5b042084a44a29c66a2c5018059
Autor:
Yuuki Shichi, Fujiya Gomi, Yasuko Hasegawa, Keisuke Nonaka, Seiichi Shinji, Kimimasa Takahashi, Toshiyuki Ishiwata
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Background: Most pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC). Spherical morphology formed in three-dimensional (3D) cultures and the effects of anticancer drugs differ between epithelial and mesenchymal PDAC cell lines. In the hum
Externí odkaz:
https://doaj.org/article/f820c6f219084e938730943ae997de86
Autor:
Keisuke Nonaka, Kaiyo Takubo, Junko Aida, Yoriko Watai, Akiko Komatsu, Fujiya Gomi, Yuuki Shichi, Yuto Yamazaki, Toshiyuki Ishiwata, Hironobu Sasano, Tomio Arai
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundThe number of patients with prolonged critical illness (PCI) has been increasing in many countries, and the adrenal gland plays an important role in maintaining homeostasis during PCI. Chronic disease burden is reportedly associated with sh
Externí odkaz:
https://doaj.org/article/8d3eff5b9ee346f5ba26e11f15240004
Autor:
Masaki Michishita, Kazuhiko Ochiai, Rei Nakahira, Daigo Azakami, Yukino Machida, Tomokazu Nagashima, Takayuki Nakagawa, Toshiyuki Ishiwata
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Mammary adenocarcinoma, the most common cancer in female dogs, often exhibits the lymph node and lung metastases and has a higher mortality rate. However, mammary adenocarcinoma has no established treatment, except early surgical excision. Canine mam
Externí odkaz:
https://doaj.org/article/68c192b5ca1742e498e9e51c465cf965
Autor:
Yuuki Shichi, Fujiya Gomi, Yoshibumi Ueda, Keisuke Nonaka, Fumio Hasegawa, Yasuko Hasegawa, Nae Hinata, Hisashi Yoshimura, Masami Yamamoto, Kimimasa Takahashi, Tomio Arai, Toshiyuki Ishiwata
Publikováno v:
Biochemistry and Biophysics Reports, Vol 32, Iss , Pp 101339- (2022)
Three-dimensional (3D) culture of cancer cells mimics the in vivo environment. Recently, we reported that pancreatic ductal adenocarcinoma (PDAC) cell lines with epithelial and mesenchymal features formed differently shaped spheres in 3D culture. How
Externí odkaz:
https://doaj.org/article/5c005926cb2e4ad599fae0a0727a0d91
Autor:
Norihiko Sasaki, Kazumi Hirano, Yuuki Shichi, Yoko Itakura, Toshiyuki Ishiwata, Masashi Toyoda
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Phenotypic switching between contractile (differentiated state) and proliferative (dedifferentiated state) vascular smooth muscle cells (VSMCs) is a hallmark of vascular remodeling that contributes to atherosclerotic diseases. Gangliosides, a group o
Externí odkaz:
https://doaj.org/article/6855753eb97e46daaa44c2f9e1904133
Autor:
Norihiko Sasaki, Seiichi Shinji, Yuuki Shichi, Toshiyuki Ishiwata, Tomio Arai, Takeshi Yamada, Goro Takahashi, Ryo Ohta, Hiromichi Sonoda, Akihisa Matsuda, Takuma Iwai, Kohki Takeda, Kazuhide Yonaga, Koji Ueda, Sho Kuriyama, Toshimitsu Miyasaka, Hiroshi Yoshida
Publikováno v:
Biochemistry and Biophysics Reports, Vol 30, Iss , Pp 101239- (2022)
Epithelial–mesenchymal transition (EMT) plays a pivotal role in cancer progression and metastasis in many types of malignancies, including colorectal cancer. Although the importance of EMT is also considered in colorectal neuroendocrine carcinoma (
Externí odkaz:
https://doaj.org/article/67c15dce15f04150a384a2098a33d490
Autor:
Fuuka Minami, Norihiko Sasaki, Yuuki Shichi, Fujiya Gomi, Masaki Michishita, Kozo Ohkusu-Tsukada, Masashi Toyoda, Kimimasa Takahashi, Toshiyuki Ishiwata
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Genetic, transcriptional, and morphological differences have been reported in pancreatic ductal adenocarcinoma (PDAC) cases. We recently found that epithelial or mesenchymal features were enhanced in three-dimensional (3D) cultures compared
Externí odkaz:
https://doaj.org/article/98c8eef5297c4fc69d1fbd8dca4302e7
Autor:
Keisuke Nonaka, Yoko Matsuda, Mototsune Kakizaki, Shoichiro Takakuma, Tomoyasu Matsubara, Shigeo Murayama, Toshiyuki Ishiwata, Masashi Kameyama, Kazuto Ogura, Sumiko Kobayashi, Tomio Arai
Publikováno v:
Urology Case Reports, Vol 23, Iss , Pp 6-9 (2019)
Mucin-producing urothelial-type adenocarcinoma of the prostate (MPUAP) is a rare, aggressive neoplasm thought to originate from the prostatic urethral urothelium. Our case is the first reported to show significantly increased serum levels of carcinoe
Externí odkaz:
https://doaj.org/article/724f2a169ee84eafa409d9c9575f6258