Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Toshiyuki, Akiyama"'
Autor:
Kuo-Hsiung Lee, Susan Morris-Natschke, Keduo Qian, Yizhou Dong, Xiaoming Yang, Ting Zhou, Eileen Belding, Shou-Fang Wu, Koji Wada, Toshiyuki Akiyama
Publikováno v:
Journal of Traditional and Complementary Medicine, Vol 2, Iss 1, Pp 6-26 (2012)
This article will review selected herbal products from Chinese Materia Medica that are used in Traditional Chinese Medicine. The herbs come from the upper, middle, and lower class medicines as listed in The Divine Husbandman's Herbal Foundation Canon
Externí odkaz:
https://doaj.org/article/4c656577615c4577ba875fb67eab7643
Autor:
Yoshiyuki Taoda, Toshiyuki Akiyama, Tomokazu Yoshinaga, Masayoshi Miyagawa, Kenji Tomita, Kenji Takaya, Kazunari Hattori, Shinya Shano, Takao Shishido, Akihiko Sato, Kazuya Yasuo, Makoto Kawai, Ryu Yoshida, Chika Takahashi-Kageyama
Publikováno v:
Journal of Medicinal Chemistry. 62:8101-8114
The medicinal chemistry and structure-activity relationships (SAR) for a novel series of carbamoyl pyridone bicycle (CAB) compounds as influenza Cap-dependent endonuclease (CEN) inhibitors are disclosed. Substituent effects were evaluated at the C (N
Autor:
Yoshiyuki, Taoda, Toshiyuki, Akiyama, Kenji, Tomita, Misato, Fujiwara-Kitamura, Yoshinori, Tamura, Takashi, Kawasuji, Eriko, Matsuoka, Erika, Akihisa, Takahiro, Seki, Tomokazu, Yoshinaga
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 64:128664
We have been conducting exploratory research to develop human immunodeficiency virus type-1 (HIV-1) integrase-LEDGF/p75 allosteric inhibitors (INLAIs). Here, we report on a newly designed compound with a tricyclic scaffold that shows promise as an in
Autor:
Yoshiyuki Taoda, Takeshi Noshi, Ryu Yoshida, Makoto Kawai, Kenji Tomita, Yasushi Hasegawa, Masayoshi Miyagawa, Toshiyuki Akiyama, Takao Shishido
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(22)
This work describes a set of discovery research studies of an influenza cap-dependent endonuclease (CEN) inhibitor with a carbamoyl pyridone bicycle (CAB) scaffold. Using influenza CEN inhibitory activity, antiviral activity and pharmacokinetic (PK)
Autor:
Takahiro Seki, Toshiyuki Akiyama, Yoshiyuki Taoda, Eriko Matsuoka, Tsutomu Iwaki, Takashi Kawasuji, Tomokazu Yoshinaga, Shuichi Sugiyama, Erika Akihisa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 33:127742
We have discovered HIV-1 novel integrase-LEDGF/p75 allosteric inhibitors (INLAIs) based on a pyridine scaffold forming an intramolecular hydrogen bond. Scaffolds containing a pyridine moiety have been studied extensively and we have already reported
Autor:
Yan Lu, Yung Yi Cheng, Ih-Sheng Chen, Toshiyuki Akiyama, Daofeng Chen, Huang Yasi, Susan L. Morris-Natschke, Chin Ho Chen, Kuo Hsiung Lee, Sheng-Zehn Yang
Publikováno v:
Phytochemistry
Bioassay-guided fractionation of the n-butanol extract from the branches and leaves of Reutealis trisperma resulted in the isolation of six undescribed (crotignoids L ~ Q) together with two known (12-deoxyphorbol-13-hexadecanoate and 12-deoxyphorbol-
Autor:
Nobumasa Ichikawa, Kazunobu Igawa, Keisuke Katanoda, Katsuhiko Tomooka, Yusuke Ano, Toshiyuki Akiyama, Masato Ito
Publikováno v:
Journal of the American Chemical Society. 137:7294-7297
The highly enantioselective synthesis of planar-chiral nine-membered cyclic amides was achieved by the Pd-catalyzed asymmetric allylic cyclization of achiral linear precursors in the presence of a catalytic amount of chiral ligand.
Autor:
Takashi Watanabe, Wei Li, Aya Sukemori, Keduo Qian, Kuber J. Malla, Xinzhu Kuang, Kyoko Nakagawa-Goto, Kazuo Koike, Takafumi Yoshikawa, Toshiyuki Akiyama, Susan L. Morris-Natschke, Yoshihisa Asada, Chin Ho Chen, Kuo Hsiung Lee, Yan Lu
Publikováno v:
Journal of Natural Products. 76:852-857
Five novel tigliane-type diterpenes, stelleracins A-E (3-7), a novel flavanone dimer, chamaeflavone A (8), and six known compounds were isolated from the roots of Stellera chamaejasme. Their structures were elucidated by extensive spectroscopic analy
Autor:
Takashi Kawasuji, Brian A. Johns, Hiroshi Yoshida, Jason G. Weatherhead, Toshiyuki Akiyama, Teruhiko Taishi, Yoshiyuki Taoda, Minako Mikamiyama-Iwata, Hitoshi Murai, Ryuichi Kiyama, Masahiro Fuji, Norihiko Tanimoto, Tomokazu Yoshinaga, Takahiro Seki, Masanori Kobayashi, Akihiko Sato, Edward P. Garvey, Tamio Fujiwara
Publikováno v:
Journal of Medicinal Chemistry. 56:1124-1135
This work is a continuation of our initial discovery of a potent monocyclic carbamoyl pyridone human immunodeficiency virus type-1 (HIV-1) integrase inhibitor that displayed favorable antiviral and pharmacokinetic properties. We report herein a serie
Autor:
Takao Shishido, Minako Mikamiyama-Iwata, Yoshiyuki Taoda, Tomokazu Yoshinaga, Ryu Yoshida, Naoko Kurihara, Naoyuki Suzuki, Kenji Morimoto, Noriyuki Kurose, Masayoshi Miyagawa, Hidenori Mikamiyama, Makoto Kawai, Kazunari Hattori, Kenji Tomita, Chika Takahashi-Kageyama, Toshiyuki Akiyama, Kenji Matsuo, Kenji Takaya, Akihiko Sato
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(19)
We report the discovery of a novel series of influenza Cap-dependent EndoNuclease (CEN) inhibitors based on the 4-pyridone-carboxylic acid (PYXA) scaffold, which were found from our chelate library. Our SAR research revealed the lipophilic domain to