Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Toshiyasu Hombo"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 99, Iss 5, Pp 531-541 (2005)
Drug concentrations that would prolong repolarization parameters by 10%, including action potential duration (APD90, APD30–90), in in vitro assays using guinea-pig papillary muscle and QTc intervals in in vivo assays using conscious dogs, conscious
Externí odkaz:
https://doaj.org/article/2ff79cca06784244afa7f886f2058e93
Autor:
Seiji Hayashi, Yoshihide Kii, Mitsuyasu Tabo, Hitoshi Fukuda, Tetsuji Itoh, Takashi Shimosato, Hideto Amano, Mamoru Saito, Hajime Morimoto, Kiyoshi Yamada, Atsuhiro Kanda, Toshimasa Ishitsuka, Takanobu Yamazaki, Yoichi Kiuchi, Shinya Taniguchi, Tatsuya Mori, Shigekazu Shimizu, Yuji Tsurubuchi, Shun-ichi Yasuda, Shin-ichi Kitani, Chiaki Shimada, Kazuo Kobayashi, Masaharu Komeno, Chieko Kasai, Toshiyasu Hombo, Keiji Yamamoto
Publikováno v:
Journal of Pharmacological Sciences, Vol 99, Iss 5, Pp 423-437 (2005)
To construct a non-clinical database for drug-induced QT interval prolongation, the electrophysiological effects of 11 positive and 10 negative compounds on action potentials (AP) in guinea-pig papillary muscles were investigated in a multi-site stud
Externí odkaz:
https://doaj.org/article/a0418258c79346d3ac043532653edbdc
Autor:
Kentaro Ando, Toshiyasu Hombo, Akihiro Kanno, Hironobu Ikeda, Masakazu Imaizumi, Noritsugu Shimizu, Kengo Sakamoto, Shin-ichi Kitani, Yoshinori Yamamoto, Shingo Hizume, Keiko Nakai, Tetsuya Kitayama, Keiji Yamamoto
Publikováno v:
Journal of Pharmacological Sciences, Vol 99, Iss 5, Pp 487-500 (2005)
In safety pharmacology studies, the effects on the QT interval of electrocardiograms are routinely assessed using a telemetry system in cynomolgus monkeys. However, there is a lack of integrated databases concerning in vivo QT assays in conscious mon
Externí odkaz:
https://doaj.org/article/756283a326c14e85af378ba65971ec91
Autor:
Yoshihide Kii, Seiji Hayashi, Mitsuyasu Tabo, Takashi Shimosato, Hitoshi Fukuda, Tetsuji Itoh, Hideto Amano, Mamoru Saito, Hajime Morimoto, Kiyoshi Yamada, Atsuhiro Kanda, Toshimasa Ishitsuka, Takanobu Yamazaki, Yoichi Kiuchi, Shinya Taniguchi, Tatsuya Mori, Shigekazu Shimizu, Yuji Tsurubuchi, Shun-ichi Yasuda, Shin-ichi Kitani, Chiaki Shimada, Kazuo Kobayashi, Masaharu Komeno, Chieko Kasai, Toshiyasu Hombo, Keiji Yamamoto
Publikováno v:
Journal of Pharmacological Sciences, Vol 99, Iss 5, Pp 449-457 (2005)
Certain compounds that prolong QT interval in humans have little or no effect on action-potential (AP) duration used traditionally, but they inhibit rapidly-activated-delayed-rectifier potassium currents (IKr) and/or human ether-a-go-go-related gene
Externí odkaz:
https://doaj.org/article/607f605ce3e84d8090d1635dfe43b73c
Publikováno v:
Handbook of experimental pharmacology. 229
Professor Gerhard Zbinden recognized in the 1970s that the standards of the day for testing new candidate drugs in preclinical toxicity studies failed to identify acute pharmacodynamic adverse events that had the potential to harm participants in cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0e14e13584d1c741d6a54c62a7c2f7e1
https://pubmed.ncbi.nlm.nih.gov/26091634
https://pubmed.ncbi.nlm.nih.gov/26091634
Publikováno v:
Principles of Safety Pharmacology ISBN: 9783662469422
Professor Gerhard Zbinden recognized in the 1970s that the standards of the day for testing new candidate drugs in preclinical toxicity studies failed to identify acute pharmacodynamic adverse events that had the potential to harm participants in cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::732fb27d1ab19ded2fe356453ee6d287
https://doi.org/10.1007/978-3-662-46943-9_1
https://doi.org/10.1007/978-3-662-46943-9_1
Autor:
Kazuo Kobayashi, Hideto Amano, Tetsuji Itoh, Mamoru Saito, Yoshihide Kii, Shinya Taniguchi, Yoichi Kiuchi, Takashi Shimosato, Shun-ichi Yasuda, Chieko Kasai, Yuji Tsurubuchi, Toshimasa Ishitsuka, Tatsuya Mori, Seiji Hayashi, Kiyoshi Yamada, Mitsuyasu Tabo, Hajime Morimoto, Chiaki Shimada, Hitoshi Fukuda, Shin-ichi Kitani, Atsuhiro Kanda, Keiji Yamamoto, Toshiyasu Hombo, Masaharu Komeno, Takanobu Yamazaki, Shigekazu Shimizu
Publikováno v:
Journal of Pharmacological Sciences, Vol 99, Iss 5, Pp 423-437 (2005)
To construct a non-clinical database for drug-induced QT interval prolongation, the electrophysiological effects of 11 positive and 10 negative compounds on action potentials (AP) in guinea-pig papillary muscles were investigated in a multi-site stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f709bc0b147b24d29b688464309466
https://doi.org/10.1254/jphs.qt-a1
https://doi.org/10.1254/jphs.qt-a1
Publikováno v:
Journal of Pharmacological Sciences, Vol 99, Iss 5, Pp 531-541 (2005)
Drug concentrations that would prolong repolarization parameters by 10%, including action potential duration (APD90, APD30–90), in in vitro assays using guinea-pig papillary muscle and QTc intervals in in vivo assays using conscious dogs, conscious
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0e0768eb76224fd2f8a8d0de073afe
https://pubmed.ncbi.nlm.nih.gov/16493193
https://pubmed.ncbi.nlm.nih.gov/16493193
Autor:
Toshimasa Ishitsuka, Masaharu Komeno, Shin-ichi Kitani, Kazuo Kobayashi, Shinya Taniguchi, Shun-ichi Yasuda, Toshiyasu Hombo, Yuji Tsurubuchi, Yoshihide Kii, Hajime Morimoto, Keiji Yamamoto, Tatsuya Mori, Tetsuji Itoh, Takanobu Yamazaki, Kiyoshi Yamada, Chieko Kasai, Mitsuyasu Tabo, Takashi Shimosato, Chiaki Shimada, Atsuhiro Kanda, Hitoshi Fukuda, Hideto Amano, Yoichi Kiuchi, Mamoru Saito, Shigekazu Shimizu, Seiji Hayashi
Publikováno v:
Journal of Pharmacological Sciences, Vol 99, Iss 5, Pp 449-457 (2005)
Certain compounds that prolong QT interval in humans have little or no effect on action-potential (AP) duration used traditionally, but they inhibit rapidly-activated-delayed-rectifier potassium currents (IKr) and/or human ether-a-go-go-related gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f069beb63d777b3d1c3835ebb5eb7be
https://pubmed.ncbi.nlm.nih.gov/16493186
https://pubmed.ncbi.nlm.nih.gov/16493186
Autor:
Hiroshi Morikawa, Takashi Hayashi, Shin-ichi Sato, Toshiyasu Hombo, Setsuko Matsumoto, Atsushi Sugiyama, Kengo Sakamoto, Yasue Sakaguchi
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 68:e16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5fda94952986b2b4093f8501f1ab54f
https://doi.org/10.1016/j.vascn.2013.01.066
https://doi.org/10.1016/j.vascn.2013.01.066