Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Toshiya Takamura"'
Autor:
Taeko Kobayashi, Wenhui Piao, Toshiya Takamura, Hiroshi Kori, Hitoshi Miyachi, Satsuki Kitano, Yumiko Iwamoto, Mayumi Yamada, Itaru Imayoshi, Seiji Shioda, Andrea Ballabio, Ryoichiro Kageyama
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
It remains unclear why quiescent neural stem cells (qNSCs) in the subventricular zone of the mouse brain have enlarged lysosomes. Here, authors demonstrate that qNSCs exhibit higher lysosomal activity and degrade activated EGF receptor by endolysosom
Externí odkaz:
https://doaj.org/article/4691a3fa38a34ed4b3aef31a73471536
Autor:
Toshiyuki Sakai, Osamu Ukimura, Tsuneharu Miki, Yukako Morioka, Toshiya Takamura, Yuichi Aono, Tomoyuki Taniguchi, Shusuke Yasuda, Mano Horinaka, Seijiro Toriyama
T24 or UM-UC-11 cells were treated with the indicated concentrations of OBP-801 and/or celecoxib for 48 h in T24 cells or 72 h in UM-UC-11 cells. A. Quantitative real-time RT-PCR of DR5 mRNA. The internal control was β2MG. Values show fold change in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c51d693740aed67b2197e0754ec99f2
https://doi.org/10.1158/1535-7163.22504234
https://doi.org/10.1158/1535-7163.22504234
Autor:
Toshiyuki Sakai, Osamu Ukimura, Tsuneharu Miki, Yukako Morioka, Toshiya Takamura, Yuichi Aono, Tomoyuki Taniguchi, Shusuke Yasuda, Mano Horinaka, Seijiro Toriyama
A. T24 cells were treated with the indicated concentrations of OBP-801 and/or celecoxib for 24 h. Cell lysates were subjected to immunoprecipitation with anti-DR5 antibody or an isotype control. Input cell lysates and anti-DR5 immunoprecipitates were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6c21e375ce4dc3e0fbae690d27ebff
https://doi.org/10.1158/1535-7163.22504228
https://doi.org/10.1158/1535-7163.22504228
Autor:
Toshiyuki Sakai, Osamu Ukimura, Tsuneharu Miki, Yukako Morioka, Toshiya Takamura, Yuichi Aono, Tomoyuki Taniguchi, Shusuke Yasuda, Mano Horinaka, Seijiro Toriyama
A. UM-UC-11 cells were treated with the indicated concentrations of OBP-801 and/or celecoxib for 72 h. Quantitative real-time RT-PCR of TRAIL mRNA was performed. The internal control was β2MG. Values show fold change in TRAIL mRNA expression compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c033076cddf6f19b161454aef2176a3
https://doi.org/10.1158/1535-7163.22504231
https://doi.org/10.1158/1535-7163.22504231
Autor:
Toshiyuki Sakai, Osamu Ukimura, Tsuneharu Miki, Yukako Morioka, Toshiya Takamura, Yuichi Aono, Tomoyuki Taniguchi, Shusuke Yasuda, Mano Horinaka, Seijiro Toriyama
T24 or UM-UC-11 cells were treated with the indicated concentrations of OBP-801 and/or celecoxib for 48 h in T24 cells or 72 h in UM-UC-11 cells. Quantitative real-time RT-PCR of FLIP (A) and survivin (B) mRNA were performed. The internal control was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116ddddbc9626d5616878798d353d527
https://doi.org/10.1158/1535-7163.22504237
https://doi.org/10.1158/1535-7163.22504237
Autor:
Takeshi Yamada, Takashi Ueda, Osamu Ukimura, Fumiya Hongo, Takumi Shiraishi, Koji Okihara, Atsuko Fujihara, Toshiya Takamura, Terukazu Nakamura, Yasuhiro Yamada, Masakatsu Oishi
Publikováno v:
International Journal of Urology. 27:134-139
OBJECTIVES To determine the safety and efficacy of the combined regimen of paclitaxel and ifosfamide plus nedaplatin for patients with refractory or relapsed germ cell tumors and impaired renal function. METHODS Of a total of 68 patients who received
Publikováno v:
Clinical Nuclear Medicine; Mar2024, Vol. 49 Issue 3, p287-288, 2p
Autor:
Yuichi Aono, Seijiro Toriyama, Yukako Morioka, Toshiyuki Sakai, Toshiya Takamura, Tsuneharu Miki, Mano Horinaka, Tomoyuki Taniguchi, Shusuke Yasuda, Osamu Ukimura
Publikováno v:
Molecular Cancer Therapeutics. 15:2066-2075
The prognosis of muscle-invasive bladder cancer with metastasis is poor. There have been no therapeutic improvements for many years, and an innovative therapy for muscle-invasive bladder cancer has been awaited to replace the conventional cytotoxic c
Autor:
Itaru Imayoshi, Hiroshi Kori, Ryoichiro Kageyama, Wenhui Piao, Seiji Shioda, Yumiko Iwamoto, Toshiya Takamura, Satsuki Kitano, Hitoshi Miyachi, Mayumi Yamada, Andrea Ballabio, Taeko Kobayashi
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Quiescence is important for sustaining neural stem cells (NSCs) in the adult brain over the lifespan. Lysosomes are digestive organelles that degrade membrane receptors after they undergo endolysosomal membrane trafficking. Enlarged lysosomes are pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78f1929b219a1976acfba95b8f1e2a4
http://hdl.handle.net/11588/782010
http://hdl.handle.net/11588/782010
Autor:
Yoshihiro Sowa, Yuichi Aono, Tsuneharu Miki, Toshiya Takamura, Mano Horinaka, Seijiro Toriyama, Toshiyuki Sakai, Osamu Ukimura, Shusuke Yasuda
Publikováno v:
Oncology Reports.
In advanced bladder cancer, cisplatin-based chemotherapy has been the standard treatment for many years, but there are many problems in terms of side-effects. Recently, a number of clinical trials using molecular-targeted agents have been conducted,