Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Toshiya Morie"'
Autor:
Aya Harada Takeda, Toshiya Morie, Kentaro Jingushi, Masatatsu Yamamoto, Souta Iyama, Ikumi Ohshio, Hiroaki Hase, Shintarou Fujii, Masami Sato, Zenzaburo Tozuka, Yuko Ueda, Kazuhiro Ueda, Kazutake Tsujikawa, Shohei Sato, Kentaro Minami, Takahiro Kogaki, Daisuke Saigusa, Tatsuhiko Furukawa, Toshiyuki Nagata, Masaya Aoki, Kaori Kitae, Kohichi Kawahara, Hasumi Ura
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 197
There are more than 150 types of naturally occurring modified nucleosides, which are believed to be involved in various biological processes. Recently, an ultrahigh performance liquid chromatography-electrospray ionization-tandem mass spectrometry (U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82fdf55b1ad28f84f4d14a3d1c8fb57
https://pubmed.ncbi.nlm.nih.gov/33601155
https://pubmed.ncbi.nlm.nih.gov/33601155
Autor:
Tomoko Kitano, Toshiya Morie, Mitsue Notake, Yayoi Honda, Seiji Iwama, Yuji Sato, Fumiyo Fukuya
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 25:1376-1382
Objectives— We performed a detailed kinetic analysis in a rat balloon injury model to clarify the essential roles of αvβ3 integrin and endothelial cell (EC) regeneration in neointima formation. Using this model, we evaluated the antistenotic effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a93c1618f559ae3eb8892ae21be828
https://doi.org/10.1161/01.atv.0000168902.18672.2f
https://doi.org/10.1161/01.atv.0000168902.18672.2f
Publikováno v:
Tetrahedron. 54:10671-10676
An efficient and practical method for synthesis of the optically active hexahydro-1,4-diazepine 2 , which is a key intermediate of DAT-582, a potent and selective serotonin-3 receptor antagonist, is described. Treatment of the ( R )-1,2,3-trisubstitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::365b685d58b325eb016e2c731045e6f1
https://doi.org/10.1016/s0040-4020(98)00616-4
https://doi.org/10.1016/s0040-4020(98)00616-4
Publikováno v:
Chemical and Pharmaceutical Bulletin. 46:1160-1164
An efficient and practical method for large scale synthesis of (R)-6-benzyloxycarbonylamino-1-methyl-4-(3-methylbenzyl)hexahydro-1, 4-diazepine (R-3), which is a key intermediate in the synthesis of DAT-582, a potent and selective serotonin-3 recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bf1749d764c9e3e19fcc81189b98e19
https://doi.org/10.1248/cpb.46.1160
https://doi.org/10.1248/cpb.46.1160
Publikováno v:
Journal of Synthetic Organic Chemistry, Japan. 56:851-862
Gastrointestinal motility dysfunctions entailed in non ulcer dyspepsia, gastroparesis and reflex oesophagitis are known to be effectively treated with the gastroprokinetic agents e.g. metoclopramide and cisapride. The mechanism of gastroprokinetic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b715b613c3890192aa96ad95ef026f5f
https://doi.org/10.5059/yukigoseikyokaishi.56.851
https://doi.org/10.5059/yukigoseikyokaishi.56.851
Publikováno v:
Tetrahedron: Asymmetry. 8:2367-2374
(±)- N -[1-Methyl-4-(3-methylbenzyl)hexahydro-1 H -1,4-diazepin-6-yl]-1 H -indazole-3-carboxamide (±)- 1 was prepared from N -methyl- N ′-(3-methylbenzyl)-ethylenediamine 5 and 2-(1-benzyloxycarbonyl-1 H -indazole-3-carbonylamino)propenal 4 and w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc5718b1d1420cf55bf88eff2241031d
https://doi.org/10.1016/s0957-4166(97)00248-6
https://doi.org/10.1016/s0957-4166(97)00248-6
Publikováno v:
Synthetic Communications. 27:559-566
The convenient large-scale synthesis of the title compound, which is the intermediate of potent 5-HT3 receptor antagonist, N-(1-benzyl-4-memylhexahydro-1H-1,4-diazepin-6-yl)-1H-indazole-3-carboxamide (1), is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5eca5535e941059400e6500cd97bceec
https://doi.org/10.1080/00397919708003326
https://doi.org/10.1080/00397919708003326
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :3219-3226
An efficient and practical method for the synthesis of (6R)-6-amino-1-methyl-4-(3-methylbenzyl)hexahydro-1H-1,4-diazepine 2, which serves as the amine part of DAT-582, a potent and selective 5-HT3 receptor antagonist, is described. The key intermedia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b1d8da83e640a6e38105b6930bbe210
https://doi.org/10.1039/a703661b
https://doi.org/10.1039/a703661b
Autor:
Toshiya Morie, Shiro Kato
Publikováno v:
Journal of Heterocyclic Chemistry. 33:1171-1178
As a part of metabolic studies of mosapride (1), a potential gastroprokinetic agent, the synthesis of 4-chloro-7-ethoxy-2(3H)-benzoxazolone-6-carboxylic acid (7) as a derivative of 4-amino-5-chloro-2-ethoxy-3-hydroxybenzoic acid (6), which has served
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03f9412ccb38a650197cb3c49f58fe56
https://doi.org/10.1002/jhet.5570330428
https://doi.org/10.1002/jhet.5570330428
Publikováno v:
Chemical and Pharmaceutical Bulletin. 44:1484-1492
To confirm the proposed structures of the minor metabolites of a potential gastroprokinetic agent, mosapride, 4-amino-5-chloro-2-ethoxy-3-hydroxy-N-(2-morpholinylmethyl)benzamide (3) and the N-(5-oxo-2-morpholinyl)-methyl analogue 4 were prepared. As
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb4a764013d2fcfe397bdee457da6a9
https://doi.org/10.1248/cpb.44.1484
https://doi.org/10.1248/cpb.44.1484