Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Toshiya Matsubara"'
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0306856 (2024)
Site-specific modifications of aspartate residues spontaneously occur in crystallin, the major protein in the lens. One of the primary modification sites is Asp151 in αA-crystallin. Isomerization and racemization alter the crystallin backbone struct
Externí odkaz:
https://doaj.org/article/9bac5b0f7b3a4e8ca8f302f56032cda6
Publikováno v:
ACS Omega, Vol 5, Iss 42, Pp 27626-27632 (2020)
Externí odkaz:
https://doaj.org/article/956e607a81844f849453600fbcca338d
Autor:
Ghupurjan Gheni, Masahito Ogura, Masahiro Iwasaki, Norihide Yokoi, Kohtaro Minami, Yasumune Nakayama, Kazuo Harada, Benoit Hastoy, Xichen Wu, Harumi Takahashi, Kazushi Kimura, Toshiya Matsubara, Ritsuko Hoshikawa, Naoya Hatano, Kenji Sugawara, Tadao Shibasaki, Nobuya Inagaki, Takeshi Bamba, Akira Mizoguchi, Eiichiro Fukusaki, Patrik Rorsman, Susumu Seino
Publikováno v:
Cell Reports, Vol 9, Iss 2, Pp 661-673 (2014)
Incretins, hormones released by the gut after meal ingestion, are essential for maintaining systemic glucose homeostasis by stimulating insulin secretion. The effect of incretins on insulin secretion occurs only at elevated glucose concentrations and
Externí odkaz:
https://doaj.org/article/63c84696f9bd4fb8a77b9baf72fed23b
Publikováno v:
Experimental Eye Research. 182:10-18
Aggregation of lens protein is a major cause of senile cataract. Lens crystallins contain many kinds of modification that accumulate over lifespan. In particular, isomerization of Asp 151 in αA-crystallin has been found in aged lenses; however, its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae291e22e332a00ebe0c129b4696aa5
https://doi.org/10.1016/j.exer.2019.02.023
https://doi.org/10.1016/j.exer.2019.02.023
Publikováno v:
ACS Omega
ACS Omega, Vol 5, Iss 42, Pp 27626-27632 (2020)
ACS Omega, Vol 5, Iss 42, Pp 27626-27632 (2020)
Traditionally, studies of post translational modifications (PTMs) by mass analysis have been limited to modifications such as deamidation and oxidation that have a mass shift. Although Asp isomerization is an important PTM, the selective detection of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6dd321a9870cf1e7311df979faca85
https://pubmed.ncbi.nlm.nih.gov/33134726
https://pubmed.ncbi.nlm.nih.gov/33134726
Autor:
Tamaki Koide, Takumi Takata, Toshiya Matsubara, Rintaro Inoue, Ingu Kim, Kousuke Magami, Masaaki Sugiyama, Ken Morishima, Noriko Fujii
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1868:140446
α-Crystallin, comprising 40-50 subunits of αA- and αB-subunits, is a long-lived major soluble chaperone protein in lens. During aging, α-crystallin forms aggregates of high molecular weight (HMW) protein and eventually becomes water-insoluble (WI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38ef81090789fea22f362281f6054f6
https://doi.org/10.1016/j.bbapap.2020.140446
https://doi.org/10.1016/j.bbapap.2020.140446
Autor:
Toshiya Matsubara, Ritsuko Hoshikawa, Naoya Hatano, Susumu Seino, Masami Shinohara, Masayuki Beppu, Eri Yoshida, Norihide Yokoi, Shihomi Hidaka, Yasuhiro Irino
Publikováno v:
Metabolomics
Biomarkers for the development of type 2 diabetes (T2D) are useful for prediction and intervention of the disease at earlier stages. In this study, we performed a longitudinal study of changes in metabolites using an animal model of T2D, the spontane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64dcce3a9f6cfb241cb3f70df6688461
https://doi.org/10.1007/s11306-015-0784-9
https://doi.org/10.1007/s11306-015-0784-9
Autor:
Ritsuko Hoshikawa, Tadao Shibasaki, Kenji Sugawara, Toshiya Matsubara, Benoit Hastoy, Masahito Ogura, Eiichiro Fukusaki, Kazuo Harada, Takeshi Bamba, Ghupurjan Gheni, Xichen Wu, Yasumune Nakayama, Susumu Seino, Nobuya Inagaki, Masahiro Iwasaki, Harumi Takahashi, Akira Mizoguchi, Naoya Hatano, Kohtaro Minami, Kazushi Kimura, Norihide Yokoi, Patrik Rorsman
Publikováno v:
Cell Reports
Cell Reports, Vol 9, Iss 2, Pp 661-673 (2014)
Cell Reports, Vol 9, Iss 2, Pp 661-673 (2014)
Summary Incretins, hormones released by the gut after meal ingestion, are essential for maintaining systemic glucose homeostasis by stimulating insulin secretion. The effect of incretins on insulin secretion occurs only at elevated glucose concentrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8880fbe6946ffcf705e39bfb7b8a654f
https://ora.ox.ac.uk/objects/uuid:abe5ec6a-9cb7-419e-ab49-2b02c2a26e9f
https://ora.ox.ac.uk/objects/uuid:abe5ec6a-9cb7-419e-ab49-2b02c2a26e9f
Autor:
Ei-ichi Matsuo, Makoto Watanabe, Toshiya Matsubara, Tetsuya Hosooka, Yoshikazu Tamori, Ayako Mita, Kohtaro Minami, Susumu Seino, Kenichi Takahashi, Osamu Nishimura, Norihide Yokoi, Sohei Kitazawa
Publikováno v:
Cell Metabolism. 15:38-50
SummaryAdipose tissue secretes adipokines that mediate insulin resistance, a characteristic feature of obesity and type 2 diabetes. By differential proteome analysis of cellular models of insulin resistance, we identified progranulin (PGRN) as an adi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad90f93e03f5f4e7994390d7b26ff5b3
https://doi.org/10.1016/j.cmet.2011.12.002
https://doi.org/10.1016/j.cmet.2011.12.002
Autor:
Ryota Seto, Katsuhiko Okumura, Makoto Watanabe, Kazuki Suganuma, Tsutomu Nakamura, Toshiro Shirakawa, Motohiro Yamamori, Toshiyuki Sakaeda, Osamu Nishimura, Megumi Kawakami, Masato Fujisawa, Jun Matsumoto, Naoki Kaneko, Tatsurou Yagami, Noboru Okamura, Akinobu Gotoh, Toshiya Matsubara, Taro Masuda, Shuji Terao
Publikováno v:
PROTEOMICS. 8:3194-3203
Renal cell carcinoma (RCC) is relatively resistant to chemotherapy and radiotherapy. Recent advances in drug development are providing novel agents for the treatment of RCC, but the effects are still minimal. In addition, there is an urgent need to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2835b979e03ceaf7caa48e4ad5c42192
https://doi.org/10.1002/pmic.200700619
https://doi.org/10.1002/pmic.200700619