Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Toshiya Kokaji"'
Autor:
Yifei Pan, Atsushi Hatano, Satoshi Ohno, Keigo Morita, Toshiya Kokaji, Yunfan Bai, Hikaru Sugimoto, Riku Egami, Akira Terakawa, Dongzi Li, Saori Uematsu, Hideki Maehara, Suguru Fujita, Hiroshi Inoue, Yuka Inaba, Atsushi J. Nagano, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-22 (2024)
Abstract Hepatic glucose metabolism serves dual purposes: maintaining glucose homeostasis and converting glucose into energy sources; however, the underlying mechanisms are unclear. We quantitatively measured liver metabolites, gene expression, and p
Externí odkaz:
https://doaj.org/article/3fcfca786a744fb18cb58409de0c7eef
Autor:
Hideki Maehara, Toshiya Kokaji, Atsushi Hatano, Yutaka Suzuki, Masaki Matsumoto, Keiichi I. Nakayama, Riku Egami, Takaho Tsuchiya, Haruka Ozaki, Keigo Morita, Masaki Shirai, Dongzi Li, Akira Terakawa, Saori Uematsu, Ken-ichi Hironaka, Satoshi Ohno, Hiroyuki Kubota, Hiromitsu Araki, Fumihito Miura, Takashi Ito, Shinya Kuroda
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Each tissue has a dominant set of functional proteins required to mediate tissue-specific functions. Epigenetic modifications, transcription, and translational efficiency control tissue-dominant protein production. However, the coordination
Externí odkaz:
https://doaj.org/article/98436c9b09ae438fad492d1943038991
Autor:
Yuki Ito, Shinsuke Uda, Toshiya Kokaji, Akiyoshi Hirayama, Tomoyoshi Soga, Yutaka Suzuki, Shinya Kuroda, Hiroyuki Kubota
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Interactions between various molecular species in biological phenomena give rise to numerous networks. The investigation of these networks, including their statistical and biochemical interactions, supports a deeper understanding of biologic
Externí odkaz:
https://doaj.org/article/d49e627e1b084f6791576e488423b87c
Autor:
Agnes Lee Chen Ong, Toshiya Kokaji, Arisa Kishi, Yoshihiro Takihara, Takuma Shinozuka, Ren Shimamoto, Ayako Isotani, Manabu Shirai, Noriaki Sasai
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108257- (2023)
Externí odkaz:
https://doaj.org/article/20529a9a47304fb7b4310447de9d6f83
Autor:
Toshiya Kokaji, Miki Eto, Atsushi Hatano, Katsuyuki Yugi, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-ichi Hironaka, Yuki Ito, Riku Egami, Saori Uematsu, Akira Terakawa, Yifei Pan, Hideki Maehara, Dongzi Li, Yunfan Bai, Takaho Tsuchiya, Haruka Ozaki, Hiroshi Inoue, Hiroyuki Kubota, Yutaka Suzuki, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Metabolic regulation in skeletal muscle is essential for blood glucose homeostasis. Obesity causes insulin resistance in skeletal muscle, leading to hyperglycemia and type 2 diabetes. In this study, we performed multiomic analysis of the ske
Externí odkaz:
https://doaj.org/article/dd5db8b9f47843dbacf9bbaaf001a016
Autor:
Akira Terakawa, Yanhui Hu, Toshiya Kokaji, Katsuyuki Yugi, Keigo Morita, Satoshi Ohno, Yifei Pan, Yunfan Bai, Andrey A. Parkhitko, Xiaochun Ni, John M. Asara, Martha L. Bulyk, Norbert Perrimon, Shinya Kuroda
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104231- (2022)
Summary: Insulin signaling promotes anabolic metabolism to regulate cell growth through multi-omic interactions. To obtain a comprehensive view of the cellular responses to insulin, we constructed a trans-omic network of insulin action in Drosophila
Externí odkaz:
https://doaj.org/article/2f11eb9ab7944adc856e74542facdc46
Autor:
Saori Uematsu, Satoshi Ohno, Kaori Y. Tanaka, Atsushi Hatano, Toshiya Kokaji, Yuki Ito, Hiroyuki Kubota, Ken-ichi Hironaka, Yutaka Suzuki, Masaki Matsumoto, Keiichi I. Nakayama, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103787- (2022)
Summary: Glucose homeostasis is maintained by modulation of metabolic flux. Enzymes and metabolites regulate the involved metabolic pathways. Dysregulation of glucose homeostasis is a pathological event in obesity. Analyzing metabolic pathways and th
Externí odkaz:
https://doaj.org/article/45123136428f459f9e3a0b9ac88e2a87
Autor:
Riku Egami, Toshiya Kokaji, Atsushi Hatano, Katsuyuki Yugi, Miki Eto, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-ichi Hironaka, Saori Uematsu, Akira Terakawa, Yunfan Bai, Yifei Pan, Takaho Tsuchiya, Haruka Ozaki, Hiroshi Inoue, Shinsuke Uda, Hiroyuki Kubota, Yutaka Suzuki, Masaki Matsumoto, Keiichi I. Nakayama, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102217- (2021)
Summary: Systemic metabolic homeostasis is regulated by inter-organ metabolic cycles involving multiple organs. Obesity impairs inter-organ metabolic cycles, resulting in metabolic diseases. The systemic landscape of dysregulated inter-organ metaboli
Externí odkaz:
https://doaj.org/article/16277b1822a647cf9a657d68049c4b26
Autor:
Kentaro Kawata, Atsushi Hatano, Katsuyuki Yugi, Hiroyuki Kubota, Takanori Sano, Masashi Fujii, Yoko Tomizawa, Toshiya Kokaji, Kaori Y. Tanaka, Shinsuke Uda, Yutaka Suzuki, Masaki Matsumoto, Keiichi I. Nakayama, Kaori Saitoh, Keiko Kato, Ayano Ueno, Maki Ohishi, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda
Publikováno v:
iScience, Vol 7, Iss , Pp 212-229 (2018)
Summary: The concentrations of insulin selectively regulate multiple cellular functions. To understand how insulin concentrations are interpreted by cells, we constructed a trans-omic network of insulin action in FAO hepatoma cells using transcriptom
Externí odkaz:
https://doaj.org/article/298b57f6bf194eb08a0765046fd90937
Autor:
Genki Kawamura, Toshiya Kokaji, Kentaro Kawata, Yuka Sekine, Yutaka Suzuki, Tomoyoshi Soga, Yoshibumi Ueda, Mizuki Endo, Shinya Kuroda, Takeaki Ozawa
Publikováno v:
Science Signaling. 16
Insulin regulates various cellular metabolic processes by activating specific isoforms of the Akt family of kinases. Here, we elucidated metabolic pathways that are regulated in an Akt2-dependent manner. We constructed a transomics network by quantif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe7f34bdfa76972c7e7c32c2b6ca3fe4
https://doi.org/10.1126/scisignal.abn0782
https://doi.org/10.1126/scisignal.abn0782