Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Toshiya Hirayama"'
Autor:
Masayuki Nakano, Kinnosuke Yahiro, Eiki Yamasaki, Hisao Kurazono, Junko Akada, Yoshio Yamaoka, Takuro Niidome, Masanori Hatakeyama, Hidekazu Suzuki, Taro Yamamoto, Joel Moss, Hajime Isomoto, Toshiya Hirayama
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 12, Pp 1473-1481 (2016)
Helicobacter pylori, a major cause of gastroduodenal diseases, produces vacuolating cytotoxin (VacA) and cytotoxin-associated gene A (CagA), which seem to be involved in virulence. VacA exhibits pleiotropic actions in gastroduodenal disorders via its
Externí odkaz:
https://doaj.org/article/b3d29d1cb8424198a3833f2db56c8fab
Autor:
Masayuki Nakano, Toshiya Hirayama
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 12, Pp 1541-1543 (2017)
Externí odkaz:
https://doaj.org/article/a2e35989b74f42f9b9ee5cf7b69801f6
Autor:
Masayuki Nakano, Eiki Yamasaki, Akitoyo Ichinose, Takaaki Shimohata, Akira Takahashi, Junko K. Akada, Kazuyuki Nakamura, Joel Moss, Toshiya Hirayama, Hisao Kurazono
Publikováno v:
Disease Models & Mechanisms, Vol 5, Iss 4, Pp 515-521 (2012)
SUMMARY The mechanism of action of Salmonella enterotoxin (Stn) as a virulence factor in disease is controversial. Studies of Stn have indicated both positive and negative effects on Salmonella virulence. In this study, we attempted to evaluate Stn f
Externí odkaz:
https://doaj.org/article/3771c26d03ce4f5a9643a324dde8ecf7
Autor:
Yuko Akazawa, Hajime Isomoto, Kayoko Matsushima, Tsutomu Kanda, Hitomi Minami, Naoyuki Yamaghchi, Naota Taura, Ken Shiozawa, Ken Ohnita, Fuminao Takeshima, Masayuki Nakano, Joel Moss, Toshiya Hirayama, Kazuhiko Nakao
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82322 (2013)
Vacuolating cytotoxin A (VacA) is one of the important virulence factors produced by H. pylori. VacA induces apoptotic cell death, which is potentiated by ammonia. VacA also causes cell death by mitochondrial damage, via signaling pathways that are n
Externí odkaz:
https://doaj.org/article/7b8b92c655b3425a9511e7a1c3219887
Publikováno v:
Toxins, Vol 8, Iss 5, p 152 (2016)
Helicobacter pylori (H. pylori), a major cause of gastroduodenal diseases, produces VacA, a vacuolating cytotoxin associated with gastric inflammation and ulceration. The C-terminal domain of VacA plays a crucial role in receptor recognition on targe
Externí odkaz:
https://doaj.org/article/5d21285275454651aa599a4d49d46d67
Autor:
Haruki Iwai, Toshihiko Yada, Akio Inui, Akihiro Asakawa, Takakazu Yagi, Yoshito Yokoyama, Masayasu Kojima, Kinnosuke Yahiro, Toshiya Hirayama, Koji Ataka, Kai-Chun Cheng, Norifumi Nakamura, Takeshi Arai, Hajime Suzuki, Katsuhiro Yamamoto, Miharu Ushikai
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Helicobacter pylori (Hp) infection is related to the pathogenesis of chronic gastric disorders and extragastric diseases. Here, we examined the anorexigenic and anxiogenic effects of Hp vacuolating cytotoxin A (VacA) through activation of hypothalami
Autor:
Toshiya Hirayama, Masayuki Nakano
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 12, Pp 1541-1543 (2017)
Disease Models & Mechanisms
Disease Models & Mechanisms
Helicobacter pylori, a major cause of gastroduodenal diseases, produces vacuolating cytotoxin (VacA) and cytotoxin-associated gene A (CagA), which seem to be involved in virulence. VacA exhibits pleiotropic actions in gastroduodenal disorders via its
Autor:
Hirokazu Yura, Bernadette R. Gochuico, Hajime Isomoto, Toshiya Hirayama, Shigeru Kohno, Anthony F. Suffredini, Noriho Sakamoto, Hiroshi Mukae, Hisao Kurazono, Tomoyuki Kakugawa, Tatsuhiko Harada, Eiki Yamasaki, Shintaro Hara, Masayuki Nakano, Yuji Ishimatsu, Atsuko Hara, Shota Nakashima, Joel Moss, Masaomi Tomonaga
Publikováno v:
Biochemical and Biophysical Research Communications. 460(3):721-726
Objective: Prior reports suggested that infection with Helicobacter pylori was associated with respiratory diseases; pathogenetic mechanisms however, were not defined. We tested the hypothesis that VacA, an exotoxin of H. pylori, a gastric pathogen,
Autor:
Kaneo Satoh1 (AUTHOR), Toshiya Hirayama2 (AUTHOR), Katsuhiro Takano1 (AUTHOR), Katsue Suzuki-Inoue1 (AUTHOR), Tadashi Sato3 (AUTHOR), Masato Ohta1 (AUTHOR), Junko Nakagomi1 (AUTHOR), Yukio Ozaki1 (AUTHOR) yozaki@yamanashi.ac.jp
Publikováno v:
Thrombosis Journal. 2013, Vol. 11 Issue 1, p23-30. 8p. 2 Black and White Photographs, 1 Chart, 3 Graphs.
Autor:
Masanori Hatakeyama, Hidekazu Suzuki, Toshifumi Hibi, Kenro Hirata, Osamu Nagano, Hitoshi Tsugawa, Toshiya Hirayama, Hideyuki Saya, Juntaro Matsuzaki
Publikováno v:
Cell Host & Microbe. 12(6):764-777
SummarySustained expression of CagA, the type IV secretion effector of Helicobacter pylori, is closely associated with the development of gastric cancer. However, we observed that after translocation, CagA is degraded by autophagy and therefore short