Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Toshitake Okui"'
Autor:
Kyoko Yoshikawa, Ikumi Chisaki, Toshitake Okui, Kazuyoshi Aso, Haruhiko Kuno, Kousuke Hidaka, Tawaraishi Taisuke, Nobuki Sakauchi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3067-3072
CCR6 has been implicated in both autoimmune diseases and non-autoimmune diseases. Thus, inhibition of CCR6-dependent cell migration is an attractive strategy for their treatment. An orally available small molecule inhibitor of CCR6 could therefore be
Autor:
Junya Shirai, Yoshiyuki Fukase, Keiko Koga, Ryoukichi Koyama, Hideyuki Nakagawa, Isaac Hoffman, Bi-Ching Sang, Mitsunori Kono, Toshitake Okui, Satoshi Yamamoto, Yasushi Fujitani, Masaharu Nakayama, Yoshihide Tomata, Robert J. Skene, Kazuko Yonemori, Atsuko Ochida, Masashi Yamasaki, Ayumu Sato
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:721-736
Novel small molecules were synthesized and evaluated as retinoic acid receptor-related orphan receptor-gamma t (RORγt) inverse agonists for the treatment of inflammatory and autoimmune diseases. A hit compound, 1, was discovered by high-throughput s
Autor:
Megumi Hirayama, Chihiro Akimoto, Toshitake Okui, Tomoki Yoshihara, Shuuichi Miyakawa, Yoshinori Satomi, Tsubasa Shiraishi, Teruki Hamada, Mayumi Nishida, Shuji Sato
Publikováno v:
Journal of Immunological Methods. 480:112751
Intracellular DNA triggers interferon release during the innate immune response. Cyclic GMP-AMP synthase (cGAS) senses intracellular double-stranded DNA not only in response to viral infection but also under autoimmune conditions. Measuring the level
Autor:
Atsuko Ochida, Yoshihide Tomata, Wes Lane, Isaac Hoffman, Masaharu Nakayama, Hideyuki Nakagawa, Ayumu Sato, Tetsuji Kawamoto, Mitsunori Kono, Toshitake Okui, Shinichi Masada, Mikio Shirasaki, Masashi Yamasaki, Yasushi Fujitani, Akira Shibata, Keiko Uga, Junya Shirai, Yoshiyuki Fukase, Kazuko Yonemori, Ryoukichi Koyama, Bi-Ching Sang, Robert J. Skene, Keiko Koga, Satoshi Yamamoto
Publikováno v:
Bioorganicmedicinal chemistry. 26(2)
A series of novel phenylglycinamides as retinoic acid receptor-related orphan receptor-gamma t (RORγt) inverse agonists were discovered through optimization of a high-throughput screen hit 1. (R)-N-(2-((3,5-Difluoro-4-(trimethylsilyl)phenyl) amino)-