Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Toshitaka Oohashi"'
Autor:
Anh Tuan Dang, Mitsuaki Ono, Ziyi Wang, Ikue Tosa, Emilio Satoshi Hara, Akihiro Mikai, Wakana Kitagawa, Tomoko Yonezawa, Takuo Kuboki, Toshitaka Oohashi
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6648 (2024)
The pathology of medication-related osteonecrosis of the jaw (MRONJ), often associated with antiresorptive therapy, is still not fully understood. Osteocyte networks are known to play a critical role in maintaining bone homeostasis and repair, but th
Externí odkaz:
https://doaj.org/article/60c4da303cb04fd0b22f183fd167e06f
Autor:
Xindi Mu, Mitsuaki Ono, Ha Thi Thu Nguyen, Ziyi Wang, Kun Zhao, Taishi Komori, Tomoko Yonezawa, Takuo Kuboki, Toshitaka Oohashi
Publikováno v:
Cells, Vol 13, Iss 10, p 807 (2024)
The oral mucosa functions as a physico-chemical and immune barrier to external stimuli, and an adequate width of the keratinized mucosa around the teeth or implants is crucial to maintaining them in a healthy and stable condition. In this study, for
Externí odkaz:
https://doaj.org/article/a0cfd4f345de434a91fdcbbeb8e92d67
Autor:
Marta Empere, Xujia Wang, Carina Prein, Anders Aspberg, Markus Moser, Toshitaka Oohashi, Hauke Clausen-Schaumann, Attila Aszodi, Paolo Alberton
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Aggrecan (ACAN) is localized in the intervertebral disc (IVD) in unique compartment-specific patterns where it contributes to the tissue structure and mechanical function together with collagens. The extracellular matrix (ECM) of the IVD undergoes de
Externí odkaz:
https://doaj.org/article/317caff3d4f9486dacbb27dd6c6ba7fa
Autor:
Hirofumi Fujita, Aoi Ando, Yohei Mizusawa, Mitsuaki Ono, Takako Hattori, Munenori Habuta, Toshitaka Oohashi, Satoshi Kubota, Hideyo Ohuchi
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0277307 (2022)
Cysteinyl leukotriene receptor 1 (CysLTR1) is a G protein-coupled receptor for the inflammatory lipid mediators cysteinyl leukotrienes, which are involved in smooth muscle constriction, vascular permeability, and macrophage chemokine release. The Cys
Externí odkaz:
https://doaj.org/article/689795256557407dbc864d988d2c5208
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The calyx of Held is a giant nerve terminal mediating high-frequency excitatory input to principal cells of the medial nucleus of the trapezoid body (MNTB). MNTB principal neurons are enwrapped by densely organized extracellular matrix structures, kn
Externí odkaz:
https://doaj.org/article/06ef2e0ecc8848e4bd342608259f7581
Autor:
Shaoying Tang, Tomoko Yonezawa, Yukihide Maeda, Mitsuaki Ono, Takahiro Maeba, Toru Miyoshi, Ryusuke Momota, Yasuko Tomono, Toshitaka Oohashi
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249909 (2021)
Congenital hearing loss affects 1 in every 1000 births, with genetic mutations contributing to more than 50% of all cases. X-linked nonsyndromic hereditary hearing loss is associated with six loci (DFNX1-6) and five genes. Recently, the missense muta
Externí odkaz:
https://doaj.org/article/9a329ebaf88d43aaa733e0a4e57761f3
Autor:
Yukie Tanaka, Kyaw Thu Aung, Mitsuaki Ono, Akihiro Mikai, Anh Tuan Dang, Emilio Satoshi Hara, Ikue Tosa, Kei Ishibashi, Aya Ono-Kimura, Kumiko Nawachi, Takuo Kuboki, Toshitaka Oohashi
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12823 (2021)
Medication-related osteonecrosis of the jaw (MRONJ) is related to impaired bone healing conditions in the maxillomandibular bone region as a complication of bisphosphonate intake. Although there are several hypotheses for the onset of MRONJ symptoms,
Externí odkaz:
https://doaj.org/article/9ec56e9b97b942b6a6029a4c2e2f207a
Autor:
Shuji Nosho, Ikue Tosa, Mitsuaki Ono, Emilio Satoshi Hara, Kei Ishibashi, Akihiro Mikai, Yukie Tanaka, Aya Kimura-Ono, Taishi Komori, Kenji Maekawa, Takuo Kuboki, Toshitaka Oohashi
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 7967 (2020)
Bone morphogenetic protein-2 (BMP-2) and fibroblast growth factor-2 (FGF-2) have been regarded as the major cytokines promoting bone formation, however, several studies have reported unexpected results with failure of bone formation or bone resorptio
Externí odkaz:
https://doaj.org/article/752cbb0842dc450dbd95dc70364c4c25
Autor:
Akihiro Mikai, Mitsuaki Ono, Ikue Tosa, Ha Thi Thu Nguyen, Emilio Satoshi Hara, Shuji Nosho, Aya Kimura-Ono, Kumiko Nawachi, Takeshi Takarada, Takuo Kuboki, Toshitaka Oohashi
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7028 (2020)
Medication-related osteonecrosis of the jaw (MRONJ) is a severe pathological condition associated mainly with the long-term administration of bone resorption inhibitors, which are known to induce suppression of osteoclast activity and bone remodeling
Externí odkaz:
https://doaj.org/article/8e07a7b332a749d6943371d92d07bbf1
Autor:
Ha Thi Thu Nguyen, Mitsuaki Ono, Emilio Satoshi Hara, Taishi Komori, Midori Edamatsu, Tomoko Yonezawa, Aya Kimura-Ono, Kenji Maekawa, Takuo Kuboki, Toshitaka Oohashi
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4739 (2019)
Epithelial keratinization involves complex cellular modifications that provide protection against pathogens and chemical and mechanical injuries. In the oral cavity, keratinized mucosa is also crucial to maintain healthy periodontal or peri-implant t
Externí odkaz:
https://doaj.org/article/68677383790341cf87740b4d703ad61e