Zobrazeno 1 - 10
of 1 090
pro vyhledávání: '"Toshitaka Nabeshima"'
Autor:
Jingzhu Liao, Geyao Dong, Wenjun Zhu, Bolati Wulaer, Hiroyuki Mizoguchi, Masahito Sawahata, Yue Liu, Kozo Kaibuchi, Norio Ozaki, Toshitaka Nabeshima, Taku Nagai, Kiyofumi Yamada
Publikováno v:
Pharmacological Research, Vol 194, Iss , Pp 106838- (2023)
Schizophrenia (SCZ) is a severe psychiatric disorder characterized by positive symptoms, negative symptoms, and cognitive deficits. Current antipsychotic treatment in SCZ improves positive symptoms but has major side effects and little impact on nega
Externí odkaz:
https://doaj.org/article/a630b78de7834853846b1611a306f2b9
Autor:
Shota Tanase, Takayoshi Mamiya, Shogo Nagata, Yusuke Ikawa, Ya-Ping Tang, Masayuki Hiramatsu, Toshitaka Nabeshima
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 4, Pp 364-368 (2022)
We examined whether galantamine (GAL), a cholinesterase inhibitor and allosteric potentiating ligand for α7 nicotinic acetylcholine receptor (nAChR), had an impact on emotional abnormalities in forebrain-specific cholecystokinin receptor-2 overexpre
Externí odkaz:
https://doaj.org/article/74567205d12e41619a12cf3ae21f3862
Autor:
Ming Tatt Lee, Akihiro Mouri, Hisayoshi Kubota, Hsin-Jung Lee, Man-Hsin Chang, Chen-Yi Wu, Daniel E. Knutson, Marko Mihovilovic, James Cook, Werner Sieghart, Toshitaka Nabeshima, Lih-Chu Chiou
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 150, Iss , Pp 113022- (2022)
GABAA receptors containing α6 subunits (α6GABAARs) in the cerebellum have -been implicated in schizophrenia. It was reported that the GABA synthesizing enzymes were downregulated whereas α6GABAARs were upregulated in postmortem cerebellar tissues
Externí odkaz:
https://doaj.org/article/3aa12603a30d404184b76fd8bb006648
Autor:
Bolati Wulaer, Kazuo Kunisawa, Moeka Tanabe, Aika Yanagawa, Kuniaki Saito, Akihiro Mouri, Toshitaka Nabeshima
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-5 (2021)
Abstract Dopamine is a key neurotransmitter that regulates attention through dopamine D1 and D2-receptors in the prefrontal cortex (PFC). We previously developed an object-based attention test (OBAT) to evaluate attention in mice. Disruption of the d
Externí odkaz:
https://doaj.org/article/2a1f55f38adb458b9673b4553b60ecf4
Autor:
Kazuhiro Hada, Bolati Wulaer, Taku Nagai, Norimichi Itoh, Masahito Sawahata, Akira Sobue, Hiroyuki Mizoguchi, Daisuke Mori, Itaru Kushima, Toshitaka Nabeshima, Norio Ozaki, Kiyofumi Yamada
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-17 (2021)
Abstract We recently found a significant association between exonic copy-number variations in the Rho GTPase activating protein 10 (Arhgap10) gene and schizophrenia in Japanese patients. Special attention was paid to one patient carrying a missense v
Externí odkaz:
https://doaj.org/article/f79b7be4ee8e4f1190170e836697c6d0
Autor:
Bolati Wulaer, Kazuo Kunisawa, Hisayoshi Kubota, Willy Jaya Suento, Kuniaki Saito, Akihiro Mouri, Toshitaka Nabeshima
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-4 (2020)
Abstract Disturbances of attention are a common behavioral feature associated with neuropsychiatric disorders with largely unknown underlying causes. We previously developed an object-based attention test (OBAT) as a simple and practical method for e
Externí odkaz:
https://doaj.org/article/5eeeeb7ee8914bdd9b9f5090864fe0d4
Autor:
Bolati Wulaer, Kazuhiro Hada, Akira Sobue, Norimichi Itoh, Toshitaka Nabeshima, Taku Nagai, Kiyofumi Yamada
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-12 (2020)
Abstract Background Immune molecules, such as cytokines, complement, and major histocompatibility complex (MHC) proteins, in the central nervous system are often associated with neuropsychiatric disorders. Neuronal MHC class I (MHCI), such as H-2D, r
Externí odkaz:
https://doaj.org/article/be3f5cb53c984c7c9f0a770a71846c80
Autor:
Kuniaki Yabe, Yasuko Yamamoto, Masao Takemura, Takeshi Hara, Hisashi Tsurumi, Ginette Serrero, Toshitaka Nabeshima, Kuniaki Saito
Publikováno v:
Heliyon, Vol 7, Iss 1, Pp e05849- (2021)
Progranulin is an autocrine growth factor that promotes proliferation, migration, invasion, and chemoresistance of various cancer cells. These mechanisms mainly depend on the protein kinase B (Akt)/mechanistic target of rapamycin (mTOR) pathway. Rece
Externí odkaz:
https://doaj.org/article/921a27ff7400478588891f966ed80494
Autor:
Daisuke Ibi, Genki Nakasai, Nayu Koide, Masahito Sawahata, Takao Kohno, Rika Takaba, Taku Nagai, Mitsuharu Hattori, Toshitaka Nabeshima, Kiyofumi Yamada, Masayuki Hiramatsu
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
In the majority of schizophrenia patients, chronic atypical antipsychotic administration produces a significant reduction in or even complete remission of psychotic symptoms such as hallucinations and delusions. However, these drugs are not effective
Externí odkaz:
https://doaj.org/article/870bd656b1574be68f8069050590b0f6
Autor:
Shinnosuke Yamada, Norimichi Itoh, Taku Nagai, Tsuyoshi Nakai, Daisuke Ibi, Akira Nakajima, Toshitaka Nabeshima, Kiyofumi Yamada
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-12 (2018)
Abstract Background Polyriboinosinic-polyribocytidylic acid (polyI:C) triggers a strong innate immune response that mimics immune activation by viral infections. Induction of interferon-induced transmembrane protein 3 (Ifitm3) in astrocytes has a cru
Externí odkaz:
https://doaj.org/article/356166b8ba0449a8a029d69b90da28aa