Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Toshiro Kamishiro"'
Publikováno v:
Japanese Journal of Pharmacology. 65:319-326
We investigated the effect of NC-1300-O-3 on gastric mucus secretion and prostaglandin release into the gastric lumen in rats. NC-1300-O-3 following single or repeated administration for up to 4 weeks significantly increased the hexose content in the
Autor:
Toshiro Kamishiro, Atsushi Takao, Yoshio Esumi, Masayuki Ichikawa, Takasi Yokota, Matsuo Takaichi
Publikováno v:
Drug Metabolism and Pharmacokinetics. 9:675-699
The matabolic fate of NC-1300-O-3, a new proton pump inhibitor with potent cytoprotective effect on the gastric mucosa, was investigated after a single oral administration of 14C(Iz)-NC-1300-O-3 or 14C(Bz)-NC-1300-O-3 to rats and male beagle dogs. 1.
Autor:
Yuji Okada, Yoshio Esumi, Sadao Tsuji, Toshiro Kamishiro, Matuo Takaichi, Atsuhiro Inaba, Masayuki Ichikawa
Publikováno v:
Drug Metabolism and Pharmacokinetics. 9:715-734
The metabolism of NC-1300-O-3, a new proton pump inhibitor with potent cytoprotective effect on the gastric mucosa, was examined after oral administration of 14C-NC-1300-O-3 in rats and dogs. 1. Following metabolites were found to be present in rat p
Publikováno v:
Japanese Journal of Pharmacology. 65:9-18
Autor:
Atsushi Takao, Masayuki Ichikawa, Takashi Yokota, Yoshio Esumi, Toshiro Kamishiro, Matsuo Takaichi
Publikováno v:
Drug Metabolism and Pharmacokinetics. 9:700-714
The metabolic fate NC-1300-O-3, a new proton pump inhibitor with potent cytoprotective effect on the gastric mucosa, was investigated after daily oral administration of 14C(Iz)-NC-1300-O-3 (30 mg/kg) for 28 days to male rats. The transfer of radioact
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 104(4)
Inhibitory action of leminoprazole ((+/-)-2-[[2-(isobutylmethylamino)benzyl]sulfinyl]-1H-benzimidazol e, NC-1300-O-3, LEM) against the H+,K(+)-ATPase activity in rabbit gastric vesicles was investigated. LEM inhibited the H+,K(+)-ATPase activity in l
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 104(2)
The inhibitory action of leminoprazole on the activity of rat gastric mucosal H+,K(+)-ATPase was investigated in vitro and ex vivo. Leminoprazole and omeprazole concentration-dependently inhibited the H+,K(+)-ATPase activity, and their IC50 values we
Publikováno v:
Journal of pharmacobio-dynamics. 11(2)
Effects of antiallergic agents on 2,4-dinitrophenylated Ascaris extract (DNP-As)-induced bronchial asthma were studied in Lewis rats, and compared with those on passive cutaneous anaphylaxis (PCA). Effects of methysergide and chlorpheniramine on the
Publikováno v:
Japanese heart journal. 23(5)
Calcium-activated neutral protease (CANP) might be involved in the irreversible degradation of myocardial proteins in the ischemic region, leading to the loss of contractility. The new compound, NCO-700, and its analogues were synthetized against CAN
Publikováno v:
Japanese heart journal. 25(4)
Using more than 500 rabbits, we found that the rabbit heart is a good model for the evaluation of drugs which affect acute myocardial infarction (AMI) size. When the ratio of the epicardial coloration area to the long axis length of the left ventricl