Výsledky vyhledávání - "Toshiro, Tsukamoto"

The life of an mRNA in space and time

Autor: Yehuda Brody, Yaron Shav-Tal, David L. Spector, Amir Mor, Toshiro Tsukamoto, Ya'ara Ben-Ari, Noa Kinor, Robert H. Singer

Publikováno v: Journal of Cell Science. 123:1761-1774

Nuclear transcribed genes produce mRNA transcripts destined to travel from the site of transcription to the cytoplasm for protein translation. Certain transcripts can be further localized to specific cytoplasmic regions. We examined the life cycle of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda6920df7739490148ffd9d0cc11cd1
https://doi.org/10.1242/jcs.062638

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SKIP modifies gene expression by affecting both transcription and splicing

Autor: Sachiko Tominaga, Nobuyuki Masuda, Tomonori Takami, Takashi Ito, Toshiro Tsukamoto, Tomohiro Yamaguchi, Keisuke Nagai, Takashi Osumi, Makoto Shimizu, Masakazu Aizawa, Aiko Kawasumi

Publikováno v: Biochemical and Biophysical Research Communications. 316:512-517

SKIP has been described as a transcriptional coregulator as well as a spliceosome component, but the relationship between these functions is not clear. We found that SKIP activated reporter gene expression from the basal promoters of viral origin. SK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18936d8bde7487f2df88d9546d00203a
https://doi.org/10.1016/j.bbrc.2004.02.077

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From Silencing to Gene Expression

Autor: Robert H. Singer, Susan M. Janicki, Yaron Shav-Tal, Edouard Bertrand, David L. Spector, William P. Tansey, Thomas Ried, Simone E Salghetti, Ravi Sachidanandam, Kannanganattu V. Prasanth, Toshiro Tsukamoto

Publikováno v: Cell. 116(5):683-698

We have developed an inducible system to visualize gene expression at the levels of DNA, RNA and protein in living cells. The system is composed of a 200 copy transgene array integrated into a euchromatic region of chromosome 1 in human U2OS cells. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228daef8b27adf169ec1c077c885a29d

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Tissue-Selective, Bidirectional Regulation of PEX11α and Perilipin Genes through a Common Peroxisome Proliferator Response Element

Autor: Ayumi Takeshita, Takashi Osumi, Toshiro Tsukamoto, Frank J. Gonzalez, Makoto Shimizu

Publikováno v: Molecular and Cellular Biology. 24:1313-1323

Most cis-acting regulatory elements have generally been assumed to activate a single nearby gene. However, many genes are clustered together, raising the possibility that they are regulated through a common element. We show here that a single peroxis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c11a0ec5244da77f2cb1206f374629
https://doi.org/10.1128/mcb.24.3.1313-1323.2004

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Peroxisomes Are Formed from Complex Membrane Structures inPEX6-deficient CHO Cells upon Genetic Complementation

Autor: Tsuneo Imanaka, Tokuko Haraguchi, Eveline Baumgart, Sadaki Yokota, Tomoko Kojidani, Yasushi Hiraoka, Toshiro Tsukamoto, Takashi Osumi, Noriyo Hashiguchi

Publikováno v: Molecular Biology of the Cell. 13:711-722

Pex6p belongs to the AAA family of ATPases. Its CHO mutant, ZP92, lacks normal peroxisomes but contains peroxisomal membrane remnants, so called peroxisomal ghosts, which are detected with anti–70-kDa peroxisomal membrane protein (PMP70) antibody.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3438d497251c2be4106bfe65742ac4dd
https://doi.org/10.1091/mbc.01-10-0479

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Catalase-less Peroxisomes

Autor: Toshiro Tsukamoto, Chiharu Fujiwara, Takashi Osumi, Yasuyuki Suzuki, Atsushi Imamura, Naomi Kondo, Nobuyuki Shimozawa, Tsuneo Imanaka, Noriyo Hashiguchi

Publikováno v: Journal of Biological Chemistry. 275:37271-37277

We established a Chinese hamster ovary cell line having a temperature-sensitive phenotype in peroxisome biogenesis. This mutant (65TS) was produced by transforming a PEX2-defective mutant, Z65, with a mutant PEX2 gene,PEX2 E55K, derived from a patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2ccfc1e1856b447f87bce2e33599ab5
https://doi.org/10.1074/jbc.m006347200

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Temperature Sensitivity in Peroxisome Assembly Processes Characterizes Milder Forms of Peroxisome Biogenesis Disorders

Autor: Chiharu Fujiwara, Nobuyuki Shimozawa, Naomi Kondo, Takashi Osumi, Atsushi Imamura, Yasuyuki Suzuki, Noriyo Hashiguchi, Toshiro Tsukamoto

Publikováno v: Cell Biochemistry and Biophysics. 32:165-170

Peroxisome biogenesis disorders (PBDs) contain various clinical phenotypes; Zellweger syndrome (ZS), neonatal adrenoleukodystrophy (NALD), and infantile Refsum disease (IRD), decreasing in the clinical severity in this order. We found that all IRD ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f508d7c61268ebbe332b0d58e694e78e
https://doi.org/10.1385/cbb:32:1-3:165

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Restoration of biochemical function of the peroxisome in the temperature-sensitive mild forms of peroxisome biogenesis disorder in humans

Autor: Takashi Osumi, Yasuyuki Suzuki, Naomi Kondo, Atsushi Imamura, Tadao Orii, Nobuyuki Shimozawa, Yukio Fujiki, Zhongyi Zhang, Toshiro Tsukamoto

Publikováno v: Brain and Development. 22:8-12

We have found that peroxisome assembly is temperature-sensitive (ts) in mild forms of peroxisome biogenesis disorders (PBDs), that is all infantile Refsum disease (IRD) patients and a few neonatal adrenoleukodystrophy patients of several complementat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98803901554c4af2b9e9fcb5a3550b0b
https://doi.org/10.1016/s0387-7604(99)00072-8

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Nonsense and temperature-sensitive mutations in PEX13 are the cause of complementation group H of peroxisome biogenesis disorders

Autor: Ronald J.A. Wanders, Atsushi Imamura, Takashi Osumi, Tadao Orii, Nobuyuki Shimozawa, Toshiro Tsukamoto, Yasuyuki Suzuki, Naomi Kondo, Zhongyi Zhang, Satoru Mukai, Ryusuke Toyama, Yukio Fujiki

Publikováno v: Human molecular genetics, 8(6), 1077-1083. Oxford University Press

Peroxisome biogenesis disorders, including Zellweger syndrome (ZS), neonatal adrenoleukodystrophy (NALD) and infantile Refsum disease, are lethal hereditary diseases caused by abnormalities in peroxisomal assembly. To date, 12 genotypes have been ide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e904b888bc1e272c6d9fe30d4eaf5a21
https://doi.org/10.1093/hmg/8.6.1077

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Genomic structure and identification of 11 novel mutations of thePEX6 (peroxisome assembly factor-2) gene in patients with peroxisome biogenesis disorders

Autor: Nobuyuki Shimozawa, Takashi Osumi, Hugo W. Moser, Yukio Fujiki, Tadao Orii, Atsushi Imamura, Yasuyuki Suzuki, Naomi Kondo, Ronald J.A. Wanders, Zhongyi Zhang, Barbara C. Paton, Peter G. Barth, Seiji Fukuda, Toshiro Tsukamoto, G. T. N. Besley

Publikováno v: Human mutation, 13(6), 487-496. Wiley-Liss Inc.

The PEX6 (peroxisome assembly factor-2, PAF-2) gene encodes a member of the AAA protein (ATPases associated with diverse cellular activities) family and restores peroxisome assembly in fibroblasts from peroxisome biogenesis disorder patients belongin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebf602bb7508e74b4c28754a3849826
https://doi.org/10.1002/(sici)1098-1004(1999)13:6<487::aid-humu9>3.0.co

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