Výsledky vyhledávání - "Toshiomi Nakate"

High-speed Analysis of Amino-sugar Compounds as Drug Substance in a Purification Process with a Core Shell Particle Column

Autor: Takahiro Wakayama, Toshiomi Nakate, Tomoko Watanabe, Momoko Inada, Satoshi Kitamura, Munekazu Kanda, Kazumi Yamamori

Publikováno v: BUNSEKI KAGAKU. 62:333-338

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::988a03212f4891b02bb371cefaef8928
https://doi.org/10.2116/bunsekikagaku.62.333

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Comparison of the lung absorption of FK224 inhaled from a pressurized metered dose inhaler and a dry powder inhaler by healthy volunteers

Autor: Atsuo Ohike, Hiromitsu Yoshida, Rinta Ibuki, Yuji Tokunaga, Yoshiaki Kawashima, Toshiomi Nakate

Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics. 56:319-325

FK224 is a cyclopeptide drug with poor oral absorption due to proteolysis in the gastrointestinal tract. The objectives of this study were to investigate the absorption of FK224 from the lung in healthy volunteers, and compare the pharmacokinetic pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72654e42d19a402b380d49a39fb120a
https://doi.org/10.1016/s0939-6411(03)00113-9

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Formulation development of inhalation powders for FK888 using the E-haler to improve the inhalation performance at a high dose, and its absorption in healthy volunteers

Autor: Yoshiaki Kawashima, Hiromitsu Yoshida, Toshiomi Nakate, Yuji Tokunaga, Rinta Ibuki, Atsuo Ohike

Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 59(1)

FK888 is a candidate selective NK1 receptor antagonist, and it exhibits poor absorption from the gastrointestinal tract in healthy volunteers. In a previous study, the optimized dry powder inhaler (DPI) formulation with carrier lactose using the Spin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ea16ef287022b9ff01e26532a1d500
https://pubmed.ncbi.nlm.nih.gov/15567298

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Establishment of new preparation method for solid dispersion formulation of tacrolimus

Autor: Toshiomi Nakate, Kazutaka Higaki, Kazuto Okimoto, Kazunari Yamashita, Rinta Ibuki, Toshikiro Kimura, Yuji Tokunaga, Atsuo Ohike

Publikováno v: International journal of pharmaceutics. 267(1-2)

The aim of this study was to establish a new preparation method for solid dispersion formulation (SDF) of tacrolimus, a poorly water-soluble drug, without dichloromethane, because no use of dichloromethane is recommended by ICH harmonized tripartite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a47f39784016f458975af53841767c8
https://pubmed.ncbi.nlm.nih.gov/14602386

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Formulation development of inhalation powders for FK888 with carrier lactose using Spinhaler and its absorption in healthy volunteers

Autor: Atsuo Ohike, Yuji Tokunaga, Toshiomi Nakate, Rinta Ibuki, Hiromitsu Yoshida, Yoshiaki Kawashima

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 97(1)

(4 R )-4-Hydroxy-l-[(l-methyl-l H -indol-3-yl)carbonyl]- l -prolyl- N -benzyl- N -methyl-3-(2-naphthyl)- l -alaninamide (FK888) is a candidate selective NK1 receptor antagonist, and it exhibits poor absorption from the gastrointestinal (GI) tract in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe13038c09616887f94a758ca95f2d8
https://pubmed.ncbi.nlm.nih.gov/15147801

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Improvement of pulmonary absorption of cyclopeptide FK224 in rats by co-formulating with beta-cyclodextrin

Autor: Yuji Tokunaga, Atsuo Ohike, Toshiomi Nakate, Yoshiaki Kawashima, Rinta Ibuki, Hiromitsu Yoshida

Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 55(2)

FK224 is a cyclopeptide drug with a low aqueous solubility. Following oral administration to rats, poor absorption was observed due to proteolysis in the gastrointestinal tract. The objective of this study was to investigate the effect of the pulmona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cebd26099129516b9b1494b1567fed2
https://pubmed.ncbi.nlm.nih.gov/12637090

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