Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Toshio Yoshizawa"'
Publikováno v:
Bone Reports, Vol 10, Iss , Pp - (2019)
Osteoclasts are responsible for bone erosion in osteoporosis and rheumatoid arthritis (RA). Both Btk and Tec kinases have essential functions in osteoclast differentiation. Tirabrutinib is a highly potent and dual oral Btk/Tec inhibitor with an IC50
Externí odkaz:
https://doaj.org/article/72e064baf00e4f9791ad53496e71d49f
Publikováno v:
European Journal of Experimental Biology.
Systemic Lupus Erythematosus (SLE) is a complex and heterogeneous autoimmune disease associated with the over production of high affinity autoantibodies. Overactivity of B-cell responsiveness to immune stimulation and direct activation of circulating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79ba4d76363df06f4e6cf6c1cfb146bb
https://doi.org/10.36648/2248-9215.9.1.79
https://doi.org/10.36648/2248-9215.9.1.79
Autor:
Kohei Tanaka, Tomoko Yasuhiro, Courtney D. DiNardo, Ryohei Kozaki, Joseph D. Khoury, Marina Konopleva, Toshio Yoshizawa, Vivian Ruvolo, Huaxian Ma, Sean M. Post, Xiaorui Zhang, Steven M. Kornblau, Peter P. Ruvolo, Michael Andreeff, Jorge E. Cortes
Publikováno v:
Blood. 134:2550-2550
Background: Internal tandem duplication (ITD) mutation in Fms-like kinase 3 (FLT3) occur in ~ 25% of newly diagnosed acute myeloid leukemia (AML) patients and is associated with poor survival outcome. We recently demonstrated that the highly specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64d557a9607710ee2d5c4e56fc5dffd1
https://doi.org/10.1182/blood-2019-128626
https://doi.org/10.1182/blood-2019-128626
Publikováno v:
Bone Reports, Vol 10, Iss, Pp-(2019)
Bone Reports
Bone Reports
Osteoclasts are responsible for bone erosion in osteoporosis and rheumatoid arthritis (RA). Both Btk and Tec kinases have essential functions in osteoclast differentiation. Tirabrutinib is a highly potent and dual oral Btk/Tec inhibitor with an IC50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61080467d63f2493c72f403797253487
https://doi.org/10.1016/j.bonr.2019.100201
https://doi.org/10.1016/j.bonr.2019.100201
Autor:
Atsushi Morosawa, Tadanobu Misawa, Xu Cao, Koki Totsuka, Shigeki Hirobayashi, Toshio Yoshizawa, Takuya Suzuki, Tetsuya Uchida, Changho Chong
Publikováno v:
Nonlinear Theory and Its Applications, IEICE. 4:172-182
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb10068620ddc1e67bc58b5da4a4eb76
https://doi.org/10.1587/nolta.4.172
https://doi.org/10.1587/nolta.4.172
Publikováno v:
Journal of the Vacuum Society of Japan. 56:382-385
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7adf3475ecfa110b2e4ef0c407d7563
https://doi.org/10.3131/jvsj2.56.382
https://doi.org/10.3131/jvsj2.56.382
Autor:
Toshio Yoshizawa, Shigeki Hirobayashi, Yutaka Hasegawa, Tadanobu Misawa, Junya Suzuki, Ryohei Nakada
Publikováno v:
IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences. :1509-1517
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::605458ba5f596e968aff6553ac550b2d
https://doi.org/10.1587/transfun.e96.a.1509
https://doi.org/10.1587/transfun.e96.a.1509
Autor:
Tomoko, Yasuhiro, Wako, Sawada, Christian, Klein, Ryohei, Kozaki, Shingo, Hotta, Toshio, Yoshizawa
Publikováno v:
Leukemialymphoma. 58(3)
The activated B-cell diffuse large B-cell-like lymphoma (ABC-DLBCL) correlates with poor prognosis. The B-cell receptor signaling pathway is known to be dysregulated in NHL/CLL and given BTK is a downstream mediator of BCR signaling, BTK constitutes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4e1fbf279442130dd1105777dd6ba731
https://pubmed.ncbi.nlm.nih.gov/27684575
https://pubmed.ncbi.nlm.nih.gov/27684575
Autor:
Tomoya Ohno, Claire V. Hutchinson, John Sharpe, Guillaume Cartron, Gilles Salles, Simon Rule, Franck Morschhauser, Hideyuki Honda, Bruno Cazin, Virginia Jamieson, Shin-ichiro Abe, Lionel Karlin, Toshio Yoshizawa, Harriet S. Walter, Akihisa Nishimura, Philippe Quittet, Martin J. S. Dyer, Kevin J. Duffy, Nimish Shah, Joseph Birkett, Ceri Jones, Christopher Fegan, Nigel Courtenay-Luck
Publikováno v:
Blood
Blood, American Society of Hematology, 2016, 127 (4), pp.411-419. ⟨10.1182/blood-2015-08-664086⟩
Blood, American Society of Hematology, 2016, 127 (4), pp.411-419. ⟨10.1182/blood-2015-08-664086⟩
We report the results of a multicenter phase 1 dose-escalation study of the selective Bruton tyrosine kinase (BTK) inhibitor ONO/GS-4059 in 90 patients with relapsed/refractory B-cell malignancies. There were 9 dose-escalation cohorts ranging from 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b534430b52404c7057a10be3c08f0895
https://hal-univ-lyon1.archives-ouvertes.fr/hal-01796198
https://hal-univ-lyon1.archives-ouvertes.fr/hal-01796198
Autor:
Deepa Hammaker, Akihisa Fukushima, David L. Boyle, Gary S. Firestein, Robert L. Sah, Katharyn Topolewski, Esther Cory Burak, Toshio Yoshizawa, Meghan Edgar
Publikováno v:
Arthritis & Rheumatism. 64:678-687
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial hyperplasia and joint destruction (1). The cellular processes that contribute to RA pathogenesis are regulated by 3 families of MAPKs, namely, ERK, JNK and p38 (2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd8ee9d4be62800200f09d942dbf8c13
https://doi.org/10.1002/art.33359
https://doi.org/10.1002/art.33359