Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Toshio Yasumori"'
Publikováno v:
Biochemical Pharmacology. 65:1843-1852
The two most frequently observed single nucleotide polymorphisms (SNPs) of the human multidrug resistance 1 (MDR1) gene are 2677G/T/A (893Ala/Ser/Thr) and 3435C/T (no amino acid substitution). In this study, six forms of MDR1 cDNAs with the SNPs were
Publikováno v:
Pharmaceutical Research. 20:89-95
Purpose. Hepatobiliary excretions of drugs from the blood to the bile include two essential transmembrane processes: uptake into hepatocytes and secretion from hepatocytes. The purpose of this study was to clarify the transport mechanisms underlying
Publikováno v:
Drug Metabolism and Disposition. 30:494-497
The glucuronidation of 6-N-formylamino-12,13-dihydro-1,11-dihydroxy-13-(beta-D-glucopyranosyl)5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (compound 1), a potent inhibitor of DNA topoisomerase I, and its related indolocarbazole compounds was
Autor:
Teppei Shimizu, Hirotoshi Echizen, Noboru Tamura, Harumi Takahashi, Noriko Shioda, Hitoshi Tainaka, Toshio Yasumori, Suzuko Kubo, Yoshiaki Shimoyama, Teruki Sato
Publikováno v:
Clinical Pharmacology & Therapeutics. 66:569-581
Objective To clarify the mechanism(s) for the interaction between warfarin and benzbromarone, a uricosuric agent, and to predict changes in the in vivo pharmacokinetics of (S)-warfarin from in vitro data. Methods Warfarin enantiomers and benzbromaron
Autor:
Qing-hua Li, Lai-shun Chen, Yasushi Yamazoe, M Ueda, Toshiharu Tsuzuki, Ryuichi Kato, Joyce A. Goldstein, Toshio Yasumori
Publikováno v:
Biochemical Pharmacology. 57:1297-1303
Regio- and stereoselective hydroxylation of phenytoin was determined in liver microsomes of nine extensive (EM) and three poor metabolizers (PM) of mephenytoin. Hydroxyphenytoins (HPPH) were isolated and quantified after separation into four regio- a
Autor:
Ryuichi Kato, Toshio Yasumori
Publikováno v:
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 27:759-769
In the development of new drugs, administration doses in a clinical phase I study and the expected final clinical dose were determined from the pharmacological data and nontoxic dose in repeated toxicity studies in an animal experiment. In this repor
Publikováno v:
Pharmacogenetics. 4:323-332
Metabolism of diazepam was studied in vitro to identify the forms of cytochrome P450 (CYP) responsible for N-demethylation (nordazepam formation) and 3-hydroxylation (temazepam formation), using liver microsomes obtained from extensive (EM) and poor
Autor:
Kiyoshi Nagata, Toshio Yasumori, Shen K. Yang, Yasushi Yamazoe, Ryuichi Kato, Norie Murayama, Lai-shun Chen
Publikováno v:
Pharmacogenetics. 3:291-301
Metabolism of diazepam (DZP) was studied in vitro to clarify the involvement of different forms of hepatic cytochrome P450 (CYP) in rats, and humans of Japanese and Caucasian origin. Microsomal 3-hydroxylation was the major pathway of DZP metabolism
Publikováno v:
The Journal of Biochemistry. 109:711-717
The cDNA of a P-450 human-2 and the two other closely related cDNAs, MP-8 (two deduced amino acids substituted) and lambda hPA6 (two deduced amino acids deleted) were expressed in Saccharomyces cerevisiae cells, and their catalytic and chemical prope
Publikováno v:
Pharmaceutical research. 20(1)
Hepatobiliary excretions of drugs from the blood to the bile include two essential transmembrane processes: uptake into hepatocytes and secretion from hepatocytes. The purpose of this study was to clarify the transport mechanisms underlying these pro