Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Toshio YOSHIZAWA"'
Publikováno v:
Bone Reports, Vol 10, Iss , Pp - (2019)
Osteoclasts are responsible for bone erosion in osteoporosis and rheumatoid arthritis (RA). Both Btk and Tec kinases have essential functions in osteoclast differentiation. Tirabrutinib is a highly potent and dual oral Btk/Tec inhibitor with an IC50
Externí odkaz:
https://doaj.org/article/72e064baf00e4f9791ad53496e71d49f
Autor:
Ryohei Kozaki, Meike Vogler, Harriet S. Walter, Sandrine Jayne, David Dinsdale, Reiner Siebert, Martin J.S. Dyer, Toshio Yoshizawa
Publikováno v:
Cancers, Vol 10, Iss 4, p 127 (2018)
Bruton’s tyrosine kinase (BTK) is a key regulator of the B-cell receptor signaling pathway, and aberrant B-cell receptor (BCR) signaling has been implicated in the survival of malignant B-cells. However, responses of the diffuse large B-cell lympho
Externí odkaz:
https://doaj.org/article/c874e6fd9b0142d0ada747a7d807feb2
Publikováno v:
European Journal of Experimental Biology.
Systemic Lupus Erythematosus (SLE) is a complex and heterogeneous autoimmune disease associated with the over production of high affinity autoantibodies. Overactivity of B-cell responsiveness to immune stimulation and direct activation of circulating
Autor:
Kohei Tanaka, Tomoko Yasuhiro, Courtney D. DiNardo, Ryohei Kozaki, Joseph D. Khoury, Marina Konopleva, Toshio Yoshizawa, Vivian Ruvolo, Huaxian Ma, Sean M. Post, Xiaorui Zhang, Steven M. Kornblau, Peter P. Ruvolo, Michael Andreeff, Jorge E. Cortes
Publikováno v:
Blood. 134:2550-2550
Background: Internal tandem duplication (ITD) mutation in Fms-like kinase 3 (FLT3) occur in ~ 25% of newly diagnosed acute myeloid leukemia (AML) patients and is associated with poor survival outcome. We recently demonstrated that the highly specific
Publikováno v:
Bone Reports, Vol 10, Iss, Pp-(2019)
Bone Reports
Bone Reports
Osteoclasts are responsible for bone erosion in osteoporosis and rheumatoid arthritis (RA). Both Btk and Tec kinases have essential functions in osteoclast differentiation. Tirabrutinib is a highly potent and dual oral Btk/Tec inhibitor with an IC50
Autor:
Weiguo Zhang, Huaxian Ma, Vivian Ruvolo, Kohei Tanaka, Toshio Yoshizawa, Peter P. Ruvolo, Jorge E. Cortes, Sean M. Post, Xiaorui Zhang, Michael Andreeff, Hong Mu, Tomoko Yasuhiro
Publikováno v:
Blood. 132:2642-2642
Background: Internal tandem duplication (ITD) mutation in Fems-like kinase 3 (FLT3) occur in ~ 25% of newly diagnosed acute myeloid leukemia (AML) patients and are associated with poor survival outcome. We recently demonstrated that highly specific A
Autor:
Atsushi Morosawa, Tadanobu Misawa, Xu Cao, Koki Totsuka, Shigeki Hirobayashi, Toshio Yoshizawa, Takuya Suzuki, Tetsuya Uchida, Changho Chong
Publikováno v:
Nonlinear Theory and Its Applications, IEICE. 4:172-182
Publikováno v:
Journal of the Vacuum Society of Japan. 56:382-385
Autor:
Toshio Yoshizawa, Shigeki Hirobayashi, Yutaka Hasegawa, Tadanobu Misawa, Junya Suzuki, Ryohei Nakada
Publikováno v:
IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences. :1509-1517
Autor:
Tomoko, Yasuhiro, Wako, Sawada, Christian, Klein, Ryohei, Kozaki, Shingo, Hotta, Toshio, Yoshizawa
Publikováno v:
Leukemialymphoma. 58(3)
The activated B-cell diffuse large B-cell-like lymphoma (ABC-DLBCL) correlates with poor prognosis. The B-cell receptor signaling pathway is known to be dysregulated in NHL/CLL and given BTK is a downstream mediator of BCR signaling, BTK constitutes