Zobrazeno 1 - 10
of 211
pro vyhledávání: '"Toshio Shikata"'
Publikováno v:
Journal of Medical Primatology. 39:1-8
Background To investigate whether or not the same strain of hepatitis C virus (HCV) can twice re-infect the same chimpanzee, we analyzed nucleic and amino acid sequences in HCV hypervariable region-1 (HVR1). Two chimpanzees were inoculated, three tim
Publikováno v:
Liver. 7:290-297
Alcoholic liver disease (ALD) in Japan was compared clinicopathologically with the occurrence in the U.S.A. ALD found in Japan was more frequently complicated by other hepatic diseases including non-A, non-B chronic hepatitis than ALD found in the U.
Publikováno v:
Liver. 10:6-10
— Using Southern blot technique, the state of hepatitis B virus (HBV) DNA in liver tissue was investigated in 16 patients who were sero-negative for hepatitis B surface antigen (HBsAg) but positive for its antibody (anti-HBs). In only one case, was
Autor:
Masashi Mizokami, Toshikazu Uchida, Fusaaki Mima, Koyu Suzuki, Mitsuhiko Moriyama, Yasuyuki Arakawa, Toshio Shikata
Publikováno v:
Liver. 10:355-364
The expression of large (pre-S1), middle (pre-S2), major S (S) polypeptides of the envelope (HBs) and X peptides of hepatitis B virus (HBV) was investigated in 37 liver specimens with chronic hepatitis B by indirect immunoperoxidase staining. Primary
Autor:
Fusae Iida, Kyosuke Mizuno, Yasunori Okuda, Kouhei Komatsu, Toshikazu Uchida, Tetsuji Rikihisa, Khin Maung Win, Khin Maung Tin, Jun-Ichi Azumi, Soe Soe, Koyu Suzuki, Toshio Shikata
Publikováno v:
Liver. 9:135-145
Two cynomolgus monkeys were inoculated with a stool extract originally derived from patients suffering from enterically transmitted non-A, non-B hepatitis. Subsequently, the primates developed self-limiting acute hepatitis and their liver tissues wer
Publikováno v:
Liver. 14:251-256
We have discovered that non-A, non-B, non-C, non-D, non-E (so-called type F) acute and chronic hepatitis is caused by a hepatitis B virus (HBV) variant with mutations in the X open reading frame. This silent HBV mutant does not induce immunoserologic
Autor:
Masahiko Sugitani, Toshio Shikata
Publikováno v:
Virus Research. 56:177-182
We analyzed nucleic and amino acid sequences of the hypervariable region (HVR)-1 of the hepatitis C virus (HCV) from inocula and the infected chimpanzee sera. One milliliter each of 10(-5), 10(-3) and 10(-2) dilutions of serum no. 4, and those of 10(
Autor:
Fumihiko Komine, Nakanobu Hayashi, Yasuyuki Arakawa, Mituhiko Moriyama, Toshio Shikata, Toshikazu Uchida
Publikováno v:
International Hepatology Communications. 5:308-316
We measured the levels of three antibodies against core (JCC-2), E1 (E1–5), and E2 NS1 (E2-1) hepatitis C virus (HCV) before and after interferon (IFN) therapy in 22 patients with chronic hepatitis C and assessed the relationship between the change
Publikováno v:
Microbiology and Immunology. 40:169-176
We examined the humoral immune response to recombinant structural proteins of hepatitis C virus (HCV) such as C, E1 and E2 in immunized mice. Mice showed high induction of antibodies against these three structural proteins. Conformational and/or line