Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Toshio SUWA"'
Autor:
Koji Chiba, Haiqing Dai, Susan Johnson, Toshio Suwa, Chieko Muto, John G. Teeter, Anne B. Cropp
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 50:505-509
OBJECTIVE To evaluate the pharmacokinetics, pharmacodynamics, safety, and tolerability of PF-00734200, a potent dipeptidyl peptidase-IV (DPP-IV) inhibitor, in Japanese subjects, and compare the results with those in Western subjects. MATERIALS AND ME
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e0f241bc722d9ed0f84cb026b6bf31
https://doi.org/10.5414/cp201614
https://doi.org/10.5414/cp201614
Publikováno v:
Drug Metabolism and Pharmacokinetics. 27:405-413
Cytochrome P450 2D6 (CYP2D6), which has a large number of genetic polymorphisms, is involved in the metabolism of a wide range of substrates. Dextromethorphan (DM) is a well-known probe drug for CYP2D6 and metabolic ratio (MR) is often used to measur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebcdf03de5c74ecad5a44eb843b7f56f
https://doi.org/10.2133/dmpk.dmpk-11-rg-078
https://doi.org/10.2133/dmpk.dmpk-11-rg-078
Publikováno v:
Drug Metabolism and Pharmacokinetics. 26:236-241
Tolterodine is known as a drug which exhibits ethnic differences in pharmacokinetics between Japanese and Koreans despite genetic similarities among the populations of East Asian countries. Tolterodine is mainly metabolized by CYP2D6 to a 5-hydroxyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fd42df76a74c8d66db0029be8ae05e
https://doi.org/10.2133/dmpk.dmpk-10-rg-112
https://doi.org/10.2133/dmpk.dmpk-10-rg-112
Publikováno v:
Journal of Antimicrobial Chemotherapy. 66:165-174
it is known that the efficacy of azithromycin, in animal infection models, is best correlated with AUC/MIC. The pharmacokinetic-pharmacodynamic (PK-PD) relationship for azithromycin, however, has not been previously confirmed with clinical data. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd248fe862ae90dd0094ce2f73d8e24f
https://doi.org/10.1093/jac/dkq398
https://doi.org/10.1093/jac/dkq398
Publikováno v:
The Journal of Clinical Pharmacology. 49:1071-1078
Linezolid (Zyvox), belonging to oxazolidinone antibiotics, is commonly used for the treatment of patients infected with methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. Although linezolid has been approved worldwide,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec97ef096e5f684a77c74b0effced67f
https://doi.org/10.1177/0091270009337947
https://doi.org/10.1177/0091270009337947
Publikováno v:
Drug Metabolism and Pharmacokinetics. 20:168-176
Summary: We previously established a method to predict the drug metabolism capacity of injured liver based on pharmacokinetic estimation of the amount of cytochrome P450 (CYP) in vivo (PKCYP test), by introducing the apparent liver-to-blood free conc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d7efdd68e777ac1ced9cedde6dc0e4
https://doi.org/10.2133/dmpk.20.168
https://doi.org/10.2133/dmpk.20.168
Autor:
Atsushi Furuya, O. Kasai, M. Sato, N. Kato, Masayuki Akimoto, Hiroyasu Ogata, S. Jingu, Toshio Suwa
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 28:191-199
The prediction performances of population pharmacokinetic-pharmacodynamic analysis of the two methods (a stepwise and a simultaneous estimations) were evaluated with respect to their accuracies and precisions. A study was designed to investigate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd182d7d87313ec19d67c308647a5bfa
https://doi.org/10.1007/bf03190485
https://doi.org/10.1007/bf03190485
Autor:
Akio Suzuki, Masayuki Akimoto, Izumi Iida, Takashi Ishizaki, Masayoshi Tani, Mitsuyo Hirota, Toshio Suwa, Shohei Higuchi, Kan Chiba
Publikováno v:
Drug Metabolism and Pharmacokinetics. 18:104-113
To clarify whether CYP2C19 is involved in the overall metabolism of clarithromycin (CAM) or not, in vitro studies using human liver microsomes and recombinant CYPs were performed by an approach based on the disappearance rate of parent compound from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bedd32eecb67cc334e8955e001605c97
https://doi.org/10.2133/dmpk.18.104
https://doi.org/10.2133/dmpk.18.104
Autor:
Hiroyasu Ogata, Shohei Higuchi, Atsushi Furuya, Masayuki Akimoto, J Gotoh, M Nozawa, Toshio Suwa, Shigeji Jingu
Publikováno v:
Journal of Pharmacy and Pharmacology. 54:921-927
A simultaneous analysis of the pharmacokinetics and pharmacodynamics of TS-943, a selective non-peptide platelet glycoprotein-IIb/IIIa (GPIIb/IIIa) receptor antagonist, was made in dogs using a nonlinear mixed effect model. Plasma concentrations of T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9b8c67d034348764912a7580f3f6a2
https://doi.org/10.1211/002235702760089036
https://doi.org/10.1211/002235702760089036
Autor:
Shohei Higuchi, Masayuki Akimoto, Naokazu Nagahata, Kiyomi Fukushima, Toshio Suwa, Atsushi Furuya
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 49:99-102
Gastric pH levels were measured in samples of gastric aspirates from eight fasted beagle dogs. The gastric pH in fasting dogs fluctuated from 2.7 to 8.3, with a mean of 6.8±0.2 (SE). Each dog received the following four treatments in randomly-assign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa7c57491f01b352ee244e1946b7c71
https://doi.org/10.1016/s0939-6411(99)00070-3
https://doi.org/10.1016/s0939-6411(99)00070-3