Zobrazeno 1 - 10
of 266
pro vyhledávání: '"Toshio Okano"'
Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice.
Autor:
Yoshihisa Hirota, Kimie Nakagawa, Keigo Isomoto, Toshiyuki Sakaki, Noboru Kubodera, Maya Kamao, Naomi Osakabe, Yoshitomo Suhara, Toshio Okano
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0199856 (2018)
Calcium (Ca) absorption from the intestinal tract is promoted by active vitamin D (1α,25D3). Vitamin D not only promotes Ca homeostasis, but it also inhibits bone resorption and promotes osteogenesis, thus playing a role in the maintenance of normal
Externí odkaz:
https://doaj.org/article/50be2928bad14f6d810ba5b6e8da038f
Autor:
Kimie Nakagawa, Kiyomi Fujiwara, Akihiro Nishimura, Chinami Murakami, Kanaha Kawamoto, Chihiro Ichinose, Yumi Kunitou, Yoshitomo Suhara, Toshio Okano, Hiroshi Hasegawa
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 8, p 1971 (2019)
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) is a vitamin K2 biosynthetic enzyme. We previously showed the lethality of this enzyme in UBIAD1 knockout mice during the embryonic stage. However, the biological effects of UBIAD1 deficienc
Externí odkaz:
https://doaj.org/article/fc7a75a453804ea7ae0c09ed66f80b53
Autor:
Yoshihisa Hirota, Kimie Nakagawa, Natsumi Sawada, Naoko Okuda, Yoshitomo Suhara, Yuri Uchino, Takashi Kimoto, Nobuaki Funahashi, Maya Kamao, Naoko Tsugawa, Toshio Okano
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0125737 (2015)
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) plays a significant role in vitamin K2 (MK-4) synthesis. We investigated the enzymological properties of UBIAD1 using microsomal fractions from Sf9 cells expressing UBIAD1 by analysing MK-4
Externí odkaz:
https://doaj.org/article/fe4563ed85ec4e73b4b580a8f4f3d226
Autor:
Yoshiyuki Mizushina, Xianai Xu, Chikako Murakami, Toshio Okano, Masaharu Takemura, Hiromi Yoshida, Kengo Sakaguchi
Publikováno v:
Journal of Pharmacological Sciences, Vol 92, Iss 3, Pp 283-290 (2003)
As described previously (H. Togashi et al. Biochem Pharmacol. 1998;56:583–590), the irradiated products of provitamin D2 (ergosterol) inhibit the activities of eukaryotic DNA polymerases. In this report, therefore, we investigated whether vitamin D
Externí odkaz:
https://doaj.org/article/54dcc86120c0422baf720575370ef852
Autor:
Kimie Nakagawa, Natsumi Sawada, Yoshihisa Hirota, Yuri Uchino, Yoshitomo Suhara, Tomoka Hasegawa, Norio Amizuka, Tadashi Okamoto, Naoko Tsugawa, Maya Kamao, Nobuaki Funahashi, Toshio Okano
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104078 (2014)
UbiA prenyltransferase domain containing 1 (UBIAD1) is a novel vitamin K2 biosynthetic enzyme screened and identified from the human genome database. UBIAD1 has recently been shown to catalyse the biosynthesis of Coenzyme Q10 (CoQ10) in zebrafish and
Externí odkaz:
https://doaj.org/article/e7ed1f2851a1412ab65cc76dc2666857
Liver-specific γ-glutamyl carboxylase-deficient mice display bleeding diathesis and short life span.
Autor:
Kotaro Azuma, Tohru Tsukui, Kazuhiro Ikeda, Sachiko Shiba, Kimie Nakagawa, Toshio Okano, Tomohiko Urano, Kuniko Horie-Inoue, Yasuyoshi Ouchi, Masahito Ikawa, Satoshi Inoue
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88643 (2014)
Vitamin K is a fat-soluble vitamin that plays important roles in blood coagulation and bone metabolism. One of its functions is as a co-factor for γ-glutamyl carboxylase (Ggcx). Conventional knockout of Ggcx causes death shortly after birth in homoz
Externí odkaz:
https://doaj.org/article/152e93498b224cff9a184058adbf5bdb
Autor:
Keisuke Abe, Naoko Tsugawa, Shigeaki Yamashita, Kazuma Tanaka, Toshiyuki Sakaki, Masashi Takamatsu, Kaori Yasuda, Tatsuo Suda, Kimie Nakagawa, Miyu Nishikawa, Shinichi Ikushiro, Toshio Okano, Yoshihisa Hirota
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 185:71-79
We have reported that 25-hydroxyvitamin D3 [25(OH)D3] binds to vitamin D receptor and exhibits several biological functions directly in vitro. To evaluate the direct effect of 25(OH)D3 in vivo, we used Cyp27b1 knockout (KO) mice, which had no detecta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46cd0167de49bb7f4d941988c25e9727
https://doi.org/10.1016/j.jsbmb.2018.07.012
https://doi.org/10.1016/j.jsbmb.2018.07.012
Autor:
Toshio Okano, Kyohei Horibe, Kimie Nakagawa, Fumihiro Kawagoe, Shinichi Ikushiro, Mana Yamaguchi, Risa Okon, Toshiyuki Sakaki, Kaori Yasuda, Miyu Nishikawa, Atsushi Kittaka, Kairi Okamoto, Naoko Tsugawa, Hiroki Mano
Publikováno v:
The Journal of Biological Chemistry
CYP24A1-deficient (Cyp24a1 KO) rats were generated using the CRISPER/Cas9 system to investigate CYP24A1-dependent or -independent metabolism of 25(OH)D3, the prohormone of calcitriol. Plasma 25(OH)D3 concentrations in Cyp24a1 KO rats were approximate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e5f55b18bf5530c3adf5141ee589d56
http://europepmc.org/articles/PMC8134072
http://europepmc.org/articles/PMC8134072
Autor:
Keisuke Abe, Toshiyuki Sakaki, Kaori Yasuda, Eiichi Hinoi, Miyu Nishikawa, Toshio Okano, Yoshihisa Hirota, Naoko Tsugawa, Masashi Takamatsu, Kairi Okamoto, Kyohei Horibe, Shinichi Ikushiro, Hiroki Mano, Kimie Nakagawa, Tetsuhiro Horie
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Recent studies have suggested that vitamin D activities involve vitamin D receptor (VDR)-dependent and VDR-independent effects of 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) and 25-hydroxyvitamin D3 (25(OH)D3) and ligand-independent effects of the VDR.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92a3c59542cbd24474de7b46418da87
http://europepmc.org/articles/PMC7105495
http://europepmc.org/articles/PMC7105495
Autor:
Toshio Okano, Motoi Nishimura, Hiroshi Ihara, Naotaka Hashizume, Masakazu Miura, Sachiko Kiuchi, Kazuyuki Matsushita, Fumio Nomura, Masayuki Totani, Takayuki Ishige, Mine Yamashita, Kouichi Hirota, Isamu Kitajima, Naoko Tsugawa, Mamoru Satoh
Publikováno v:
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 55:647-656
Background To assess the vitamin D nutritional status, serum total 25-hydroxyvitamin D (25(OH)D) concentration is measured. We used six automated 25(OH)D immunoassays (AIAs) available in Japan and certified by the Vitamin D Standardization Program (V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed090047dd8f8fc90363b410cabeab8
https://doi.org/10.1177/0004563218765570
https://doi.org/10.1177/0004563218765570