Zobrazeno 1 - 10
of 482
pro vyhledávání: '"Toshio Matsuda"'
Autor:
Yuta Hara, Yukio Ago, Erika Takano, Shigeru Hasebe, Takanobu Nakazawa, Hitoshi Hashimoto, Toshio Matsuda, Kazuhiro Takuma
Publikováno v:
Molecular Autism, Vol 8, Iss 1, Pp 1-9 (2017)
Abstract Background MicroRNAs, small non-coding RNAs, are highly expressed in the mammalian brain, and the dysregulation of microRNA levels may be involved in neurodevelopmental disorders such as autism spectrum disorder (ASD). In the present study,
Externí odkaz:
https://doaj.org/article/cee650c649374e6dadc7f773cef4e6ec
Publikováno v:
Journal of MMIJ, Vol 132, Iss 8, Pp 129-136 (2016)
Computer simulation of percussive rock drilling requires appropriate numerical models for the interactions among the drill body, rod, rod joint, bit, and rock. In this study, the impact penetration of a bit into rock was investigated for the modeling
Externí odkaz:
https://doaj.org/article/7c2896628f4e4c2995937accf11700c7
Autor:
Shigeru Hasebe, Naoki Hiramatsu, Yukio Ago, Kazuya Mori, Yuji Watabe, Hitoshi Hashimoto, Kazuhiro Takuma, Toshio Matsuda
Publikováno v:
Journal of Pharmacological Sciences, Vol 127, Iss 2, Pp 232-235 (2015)
We have found that fluvoxamine-induced increases in prefrontal dopamine release are enhanced by adrenalectomy/castration and 5-HT1A receptors are involved in the enhancement. This study examined which 5-HT1A autoreceptors or postsynaptic receptor pla
Externí odkaz:
https://doaj.org/article/775c4f6fc18c4f9f8bf99541c66c7ab6
Publikováno v:
Journal of Pharmacological Sciences, Vol 125, Iss 3, Pp 237-241 (2014)
Abstract.: Post-weaning social isolation in mice induces behavioral abnormalities such as hyperactivity, aggression, depression- and anxiety-like behaviors, deficits of prepulse inhibition, and reduced pain sensitivity to the noxious stimuli. Then, t
Externí odkaz:
https://doaj.org/article/eade8b915e984a7badac179d4b753e95
Autor:
Yuki Ota, Takuya Kawanai, Ryo Watanabe, Akira Nishimura, Yukio Ago, Kazuhiro Takuma, Toshio Matsuda
Publikováno v:
Journal of Pharmacological Sciences, Vol 121, Iss 4, Pp 351-354 (2013)
Abstract.: Nitric oxide (NO) induces cytotoxicity in neuronal and glial cells via activation of the Na+/Ca2+ exchanger (NCX). This study examined the role of the predominant brain-specific NCX splice variant NCX1.5 in NO-induced cytotoxicity in the H
Externí odkaz:
https://doaj.org/article/000fdc93b7be4ddfa86a3707dd9d800f
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 4, Pp 543-546 (2012)
We have recently shown that prenatal valproic acid (VPA) exposure causes autism spectrum disorders–like behavioral abnormalities and Nissl-positive cell loss in both prefrontal and somatosensory cortices in male mice. We have also found that VPA-in
Externí odkaz:
https://doaj.org/article/47c953fc10904b5dbc7fa74492126df7
Autor:
Yukio Ago, Ryota Araki, Koji Yano, Toshiyuki Kawasaki, Shigeyuki Chaki, Atsuro Nakazato, Hirotaka Onoe, Hitoshi Hashimoto, Akemichi Baba, Kazuhiro Takuma, Toshio Matsuda
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 2, Pp 295-298 (2012)
Isolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a selective metabotropic glutamate 2/3 receptor agonist, on abnormal behaviors such as hyperactivit
Externí odkaz:
https://doaj.org/article/4e2d714e64ac47989531a1512ba36cf8
Autor:
Kazuhiro Takuma, Hiroyuki Mizoguchi, Yoko Funatsu, Yuko Kitahara, Daisuke Ibi, Hiroyuki Kamei, Toshio Matsuda, Koji Koike, Masaki Inoue, Taku Nagai, Kiyofumi Yamada
Publikováno v:
Journal of Pharmacological Sciences, Vol 120, Iss 2, Pp 89-97 (2012)
We have recently found that combination of ovariectomy (OVX) and chronic restraint stress causes cognitive dysfunction and reduces hippocampal CA3 neurons in female rats and mice and that estrogen replacement and chronic treatment with Ginkgo biloba
Externí odkaz:
https://doaj.org/article/37bf4706ff3e46b88af44833c8207911
Publikováno v:
Journal of Pharmacological Sciences, Vol 116, Iss 1, Pp 6-17 (2011)
Abstract.: Several lines of evidence suggest that cholinergic deficits may contribute to the pathophysiology of psychiatric disorders as well as Alzheimer’s disease. There is growing clinical evidence that galantamine, currently used for the treatm
Externí odkaz:
https://doaj.org/article/baa744ecce904d4b9ec62f9aee5953c0
Publikováno v:
Journal of Pharmacological Sciences, Vol 117, Iss 2, Pp 71-76 (2011)
Abstract.: Interplay between genetic and environmental factors plays a key role in psychiatric disorders, as well as other brain diseases, cancer, and metabolic syndrome. In accordance with epidemiological findings, animal studies have pointed out th
Externí odkaz:
https://doaj.org/article/6a234251ab8e4081848a420b128e087a