Zobrazeno 1 - 10
of 848
pro vyhledávání: '"Toshio MATSUMOTO"'
Autor:
Mai Kanai, Byambasuren Ganbaatar, Itsuro Endo, Yukiyo Ohnishi, Jumpei Teramachi, Hirofumi Tenshin, Yoshiki Higa, Masahiro Hiasa, Yukari Mitsui, Tomoyo Hara, Shiho Masuda, Hiroki Yamagami, Yuki Yamaguchi, Ken-ichi Aihara, Mayu Sebe, Rie Tsutsumi, Hiroshi Sakaue, Toshio Matsumoto, Masahiro Abe
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5715 (2024)
Chronic inflammation causes muscle wasting. Because most inflammatory cytokine signals are mediated via TGF-β-activated kinase-1 (TAK1) activation, inflammatory cytokine-induced muscle wasting may be ameliorated by the inhibition of TAK1 activity. T
Externí odkaz:
https://doaj.org/article/9598cba046254671827402faa5ef1389
Autor:
Bingzi Dong, Masahiro Hiasa, Yoshiki Higa, Yukiyo Ohnishi, Itsuro Endo, Takeshi Kondo, Yuichi Takashi, Maria Tsoumpra, Risa Kainuma, Shun Sawatsubashi, Hiroshi Kiyonari, Go Shioi, Hiroshi Sakaue, Tomoki Nakashima, Shigeaki Kato, Masahiro Abe, Seiji Fukumoto, Toshio Matsumoto
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Here, the authors identify interleukin-11 as a mediator of bone-adipose crosstalk during mechanical loading of the bone. Interleukin-11 secreted by the bone acts as a hormone to regulate fat metabolism, in addition to having an autocrine-paracrine ef
Externí odkaz:
https://doaj.org/article/1bbff37e27444e038f7af5c05122ae3a
Autor:
Chun-Feng Huang, Jung-Fu Chen, Ian R. Reid, Wing P. Chan, Peter Robert Ebeling, Bente Langdahl, Shih-Te Tu, Toshio Matsumoto, Ding-Cheng Chan, Yoon-Sok Chung, Fang-Ping Chen, E Michael Lewiecki, Keh-Sung Tsai, Rong-Sen Yang, Seng Bin Ang, Ko-En Huang, Yin-Fan Chang, Chung-Hwan Chen, Joon-Kiong Lee, Hsin-I Ma, Weibo Xia, Ambrish Mithal, David L. Kendler, Cyrus Cooper, Jawl-Shan Hwang, Chih-Hsing Wu
Publikováno v:
Journal of the Formosan Medical Association, Vol 122, Iss , Pp S14-S20 (2023)
Postmenopausal women are at significant risk for osteoporotic fractures due to their rapid bone loss. Half of all postmenopausal women will get an osteoporosis-related fracture over their lifetime, with 25% developing a spine deformity and 15% develo
Externí odkaz:
https://doaj.org/article/24656c182a1c4ae3a95d64a95b33384f
Autor:
Tomoyo Hara, Ryoko Uemoto, Akiko Sekine, Yukari Mitsui, Shiho Masuda, Kiyoe Kurahashi, Sumiko Yoshida, Toshiki Otoda, Tomoyuki Yuasa, Akio Kuroda, Yasumasa Ikeda, Itsuro Endo, Soichi Honda, Katsuhiko Yoshimoto, Akira Kondo, Toshiaki Tamaki, Toshio Matsumoto, Munehide Matsuhisa, Masahiro Abe, Ken‐ichi Aihara
Publikováno v:
Journal of Diabetes Investigation, Vol 12, Iss 12, Pp 2172-2182 (2021)
Abstract Aims/Introduction Thrombin exerts various pathophysiological functions by activating protease‐activated receptors (PARs). Recent data have shown that PARs influence the development of glomerular diseases including diabetic kidney disease (
Externí odkaz:
https://doaj.org/article/994aad1d67334b8989c29528c6f31641
Autor:
Xiaolin Ni, Juan Feng, Yan Jiang, Li Zhang, Wei Yu, Ou Wang, Mei Li, Xiaoping Xing, Toshio Matsumoto, Weibo Xia
Publikováno v:
Osteoporosis and Sarcopenia, Vol 7, Iss 2, Pp 47-53 (2021)
Objectives: To compare the effect of eldecalcitol and alfacalcidol on skeletal microstructure by high-resolution peripheral QCT (HR-pQCT). Methods: This was a substudy of a randomized, double-blind, active comparator trial. Five female osteoporotic p
Externí odkaz:
https://doaj.org/article/a26acb25d49c491a9012300a5990b309
Autor:
Atsushi Okada, Toshio Matsumoto, Hiroshi Ohshima, Tatsuya Isomura, Tadashi Koga, Takahiro Yasui, Kenjiro Kohri, Adrian LeBlanc, Elisabeth Spector, Jeffrey Jones, Linda Shackelford, Jean Sibonga
Publikováno v:
JBMR Plus, Vol 6, Iss 1, Pp n/a-n/a (2022)
ABSTRACT Long‐duration spaceflight is associated with an increased risk of urolithiasis, and the pain caused by urinary calculi could result in loss of human performance and mission objectives. The present study investigated the risk of urolithiasi
Externí odkaz:
https://doaj.org/article/c0cc6bd310384128956e07d370d2604b
Autor:
Hirofumi Tenshin, Jumpei Teramachi, Mohannad Ashtar, Masahiro Hiasa, Yusuke Inoue, Asuka Oda, Kotaro Tanimoto, So Shimizu, Yoshiki Higa, Takeshi Harada, Masahiro Oura, Kimiko Sogabe, Tomoyo Hara, Ryohei Sumitani, Tomoko Maruhashi, Mayu Sebe, Rie Tsutsumi, Hiroshi Sakaue, Itsuro Endo, Toshio Matsumoto, Eiji Tanaka, Masahiro Abe
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 1, Pp n/a-n/a (2022)
Abstract Objectives Aberrant NLRP3 inflammasome activation has been demonstrated in rheumatoid arthritis (RA), which may contribute to debilitating inflammation and bone destruction. Here, we explored the efficacy of the potent TGF‐β‐activated k
Externí odkaz:
https://doaj.org/article/eb6f1e9c0b8340c495804ddb1a09c4b8
Autor:
Yoshiki Higa, Masahiro Hiasa, Hirofumi Tenshin, Emiko Nakaue, Mariko Tanaka, Sooha Kim, Motosumi Nakagawa, So Shimizu, Kotaro Tanimoto, Jumpei Teramachi, Takeshi Harada, Asuka Oda, Masahiro Oura, Kimiko Sogabe, Tomoyo Hara, Ryohei Sumitani, Tomoko Maruhashi, Hiroki Yamagami, Itsuro Endo, Toshio Matsumoto, Eiji Tanaka, Masahiro Abe
Publikováno v:
Antioxidants, Vol 12, Iss 1, p 133 (2023)
Xanthine oxidoreductase (XOR) is a rate-limiting enzyme in purine catabolism that acts as a novel regulator of adipogenesis. In pathological states, xanthine oxidoreductase activity increases to produce excess reactive oxygen species (ROS). The nucle
Externí odkaz:
https://doaj.org/article/1a8368b762724ac5baaade1b3f73a634
Autor:
Kotaro Tanimoto, Masahiro Hiasa, Hirofumi Tenshin, Jumpei Teramachi, Asuka Oda, Takeshi Harada, Yoshiki Higa, Kimiko Sogabe, Masahiro Oura, Ryohei Sumitani, Tomoyo Hara, Itsuro Endo, Toshio Matsumoto, Eiji Tanaka, Masahiro Abe
Publikováno v:
Haematologica, Vol 107, Iss 3 (2021)
Externí odkaz:
https://doaj.org/article/e11dac539691425e9426b940b9e4add0
Autor:
Yuichi Takashi, Shun Sawatsubashi, Itsuro Endo, Yukiyo Ohnishi, Masahiro Abe, Munehide Matsuhisa, Daiji Kawanami, Toshio Matsumoto, Seiji Fukumoto
Publikováno v:
Biochemistry and Biophysics Reports, Vol 27, Iss , Pp 101107- (2021)
Fibroblast growth factor (FGF) 23 produced by the bone is the principal hormone to regulate serum phosphate level. Serum FGF23 needs to be tightly regulated to maintain serum phosphate in a narrow range. Thus, we hypothesized that the bone has some p
Externí odkaz:
https://doaj.org/article/dc175e87e25346f68bc8fc44a96762cc