Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Toshio Kasamatsu"'
Publikováno v:
Genes and Environment, Vol 44, Iss 1, Pp 1-8 (2022)
Abstract Bisphenol-A (BPA) is an important environmental contaminant with adverse health effects suspected to be mediated through epigenetic mechanisms. We had reported that the FLO1-dependent flocculation of transgenic yeast expressing human DNA met
Externí odkaz:
https://doaj.org/article/521c13294ad5492dac496d7ca3478b66
Autor:
Toshio Kasamatsu, Airi Kitazawa, Sumie Tajima, Masahiro Kaneko, Kei-ichi Sugiyama, Masami Yamada, Manabu Yasui, Kenichi Masumura, Katsuyoshi Horibata, Masamitsu Honma
Publikováno v:
Genes and Environment, Vol 43, Iss 1, Pp 1-17 (2021)
Abstract Background Food flavors are relatively low molecular weight chemicals with unique odor-related functional groups that may also be associated with mutagenicity. These chemicals are often difficult to test for mutagenicity by the Ames test bec
Externí odkaz:
https://doaj.org/article/231f1099647a4bfc9b82478cbe5b95a7
Publikováno v:
Genes and Environment, Vol 42, Iss 1, Pp 1-6 (2020)
Abstract Background (Quantitative) Structure-Activity Relationship ((Q)SAR) is a promising approach to predict the potential adverse effects of chemicals based on their structure without performing toxicological studies. We evaluate the mutagenicity
Externí odkaz:
https://doaj.org/article/e45ece3a0f2b4aa78b3351f63fcf3610
Publikováno v:
Genes and Environment, Vol 40, Iss 1, Pp 1-3 (2018)
Abstract We have demonstrated that retrospective evaluation of existing data of in vitro chromosomal aberration test using the new cytotoxicity indices RICC (relative increase in cell count) or RPD (relative population doubling) reduces the false-pos
Externí odkaz:
https://doaj.org/article/b3f8b5ae3e7b4bf9a06d30c83c16a84c
Publikováno v:
Genes and Environment
Genes and Environment, Vol 42, Iss 1, Pp 1-6 (2020)
Genes and Environment, Vol 42, Iss 1, Pp 1-6 (2020)
Background (Quantitative) Structure-Activity Relationship ((Q)SAR) is a promising approach to predict the potential adverse effects of chemicals based on their structure without performing toxicological studies. We evaluate the mutagenicity of food f
Autor:
Hajime Kojima1, Toshio Kasamatsu2 kasamatsu.toshio@kao.co.jp
Publikováno v:
Genes & Environment. Aug2015, Vol. 37 Issue 1, p1-9. 9p.
Publikováno v:
Genes and Environment
Genes and Environment, Vol 40, Iss 1, Pp 1-3 (2018)
Genes and Environment, Vol 40, Iss 1, Pp 1-3 (2018)
We have demonstrated that retrospective evaluation of existing data of in vitro chromosomal aberration test using the new cytotoxicity indices RICC (relative increase in cell count) or RPD (relative population doubling) reduces the false-positive rat
Autor:
Lutz Müller, Makoto Hayashi, Dan D. Levy, Lya G. Soeteman-Hernández, Maik Schuler, James T. MacGregor, George E. Johnson, Shoji Fukushima, David A. Eastmond, Roland Frötschl, Kenny S. Crump, Melanie Guérard, Véronique Thybaud, Paul D. White, Toshio Kasamatsu, Takeshi Morita, Rita Schoeny
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 783:55-65
This report summarizes the discussion, conclusions, and points of consensus of the IWGT Working Group on Quantitative Approaches to Genetic Toxicology Risk Assessment (QWG) based on a meeting in Foz do Iguacu, Brazil October 31–November 2, 2013. To
Publikováno v:
Toxicology and Applied Pharmacology. 275:213-220
Hemoglobin adducts have been used as biomarkers of exposure to reactive chemicals. Glycidol, an animal carcinogen, has been reported to form N-(2,3-dihydroxy-propyl)valine adducts to hemoglobin (diHOPrVal). To support the use of these adducts as mark
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 757:148-157
The high rate of false-positive or misleading results in in vitro mammalian genotoxicity testing is a hurdle in the development of valuable chemicals, especially those used in cosmetics, for which in vivo testing is banned in the European Union. The