Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Toshio Kamei"'
Publikováno v:
Drug Metabolism and Pharmacokinetics. 13:36-44
The concentrations of finasteride, an inhibitor of steroid 5α-reductase, and its metabolites in plasma, urine, bile, and tissue was assayed after oral or intravenous administration of 14C-finasteride to rats using radio-HPLC. Finasteride accounted f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46aa88ec159bdfc4716c4bac8cc81d7f
https://doi.org/10.2133/dmpk.13.36
https://doi.org/10.2133/dmpk.13.36
Publikováno v:
Journal of Lipid Research, Vol 36, Iss 7, Pp 1489-1497 (1995)
Recombinant rat squalene epoxidase (rSE) was expressed in E. coli and purified to an apparent homogeneity. This expression system was constructed using squalene epoxidase (SE) cDNA in which nucleotides coding 99 amino acids in the N-terminal were del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c4c595eccd3f386d9640c175bda25c
http://www.sciencedirect.com/science/article/pii/S0022227520397364
http://www.sciencedirect.com/science/article/pii/S0022227520397364
Autor:
Yasufumi Nagata, Yoshikazu Iwasawa, Toshio Kamei, Akiko Shimizu, Masahiro Horie, Toshihiko Satoh
Publikováno v:
Biochemical Pharmacology. 46:297-305
Caco-2 cells grown on membrane filters were used as a model to study the effects of NB-598, an inhibitor of squalene epoxidase, on cholesterol absorption from the intestinal epithelia. NB-598 (10 μM) inhibited the synthesis of sterol and sterol este
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8c46699bed74d6f30872840aba92b4
https://doi.org/10.1016/0006-2952(93)90418-v
https://doi.org/10.1016/0006-2952(93)90418-v
Autor:
Jun Shibata, Mari Yonemoto, Keiko Miura, Kenj Hirota, Masahiro Hayashi, Yoshikazu Iwasawa, Toshio Kamei, Morihiro Mitsuya, Koji Tomimoto, Takashi Nomoto
Publikováno v:
ChemInform. 27
A new structural class of squalene synthase (SQS) inhibitor, J-104,118, was developed by chemical modification of L-592,901. The absolute configuration of J-104,118 was determined by X-ray crystal analysis. An oral dose of J-104,118 potently inhibite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94a69c351fc9e8b1d37db5dae45b26e0
https://doi.org/10.1002/chin.199602116
https://doi.org/10.1002/chin.199602116
Autor:
Masaki Ihara, Kiyofumi Ishikawa, Fumiaki Ishida, Kaori Saeki, Toshio Kamei, Mitsuo Yano, Toshihiko Saeki
Publikováno v:
Biochemical Pharmacology. 44:1431-1436
Endothelin (ET)-1 reduced heparin-releasable lipoprotein lipase (LPL) activity in 3T3-L1 adipocytes in a concentration-dependent manner. However, a selective ETB receptor agonist, [Ala1,3,11,15]ET-1, did not act like ET-1. The ET-1-induced decrease i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776b3b1434650535c41d5e1ee13bfa1a
https://doi.org/10.1016/0006-2952(92)90545-t
https://doi.org/10.1016/0006-2952(92)90545-t
Publikováno v:
Atherosclerosis. 95:87-94
The effect of simvastatin (MK-733), a potent 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, on the migration of cultured porcine smooth muscle cells (SMCs) was investigated in modified Boyden chambers. Platelet-derived growth fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d8d1089b09679ccbf4e2e010c5b6f1
https://doi.org/10.1016/0021-9150(92)90179-k
https://doi.org/10.1016/0021-9150(92)90179-k
Autor:
Yusuke Hidaka, Toshio Kamei, Yasufumi Nagata, Fumiaki Ishida, Hisako Watanabe, Masahiro Horie, Mari Yonemoto, Masahiro Hayashi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 40:436-440
NB-598, a potent inhibitor of squalene epoxidase, inhibited cholesterol synthesis from [14C]acetate and induced intracellular squalene accumulation in Hep G2 cells. NB-598 inhibited cholesterol synthesis from [14C]acetate, [3H]mevalonate, and [3H]squ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dcf33129cdb413d199b9a7f2a2464eb
https://doi.org/10.1248/cpb.40.436
https://doi.org/10.1248/cpb.40.436
Publikováno v:
Biochemical Pharmacology. 41:1163-1172
The effect of simvastatin (MK-733), an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, on plasma triacylglycerol (TG) levels was studied in rats. Dietary administration of MK-733 (0.055%, w/w) for 7 days significantly (P less
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3046b8e0c55a7941cb8dfdda7f33de
https://doi.org/10.1016/0006-2952(91)90654-n
https://doi.org/10.1016/0006-2952(91)90654-n
Publikováno v:
Journal of Lipid Research, Vol 31, Iss 11, Pp 2087-2094 (1990)
Regulation of squalene epoxidase in the cholesterol biosynthetic pathway was studied in a human hepatoma cell line, HepG2 cells. Since the squalene epoxidase activity in cell homogenates was found to be stimulated by the addition of Triton X-100, enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2327088fa7da731fdee91342ef6c69b3
http://www.sciencedirect.com/science/article/pii/S0022227520422734
http://www.sciencedirect.com/science/article/pii/S0022227520422734
Publikováno v:
Japanese Journal of Pharmacology. 54:315-324
The effects of simvastatin (MK-733), a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, on the branched pathway of mevalonate metabolism were studied in Hep G2 cells. The synthesis of cholesterol, ubiquinone and dolichol were examined using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee39444d1b0796e6acec00f27772914
https://doi.org/10.1254/jjp.54.315
https://doi.org/10.1254/jjp.54.315