Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Toshio, Nishihara"'
Autor:
Seiji Kodama, Ikuo Fujii, Masahiro Oguri, Toshio Nishihara, Ikuhiko Nakase, Kenji Kono, Sihyun Ham, Eiji Yuba, Haeri Im, Jong Young Joung, Sunhee Cho, Daisuke Fujiwara, Hidekazu Kitada, Kazunori Shiraishi, Masataka Michigami
Publikováno v:
Angewandte Chemie International Edition. 55:10612-10615
The design of inhibitors of intracellular protein-protein interactions (PPIs) remains a challenge in chemical biology and drug discovery. We propose a cyclized helix-loop-helix (cHLH) peptide as a scaffold for generating cell-permeable PPI inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e22550ca301d3a6b22a8dedb8ab765d
https://doi.org/10.1002/anie.201603230
https://doi.org/10.1002/anie.201603230
Publikováno v:
Biopolymers. 106:415-421
Conformationally constrained peptides have been developed as an inhibitor for protein-protein interactions (PPIs), and we have de novo designed cyclized helix-loop-helix (cHLH) peptide with a disulfide bond consisting of 40 amino acids to generate mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::494560bf38933343807215d5f0a026a5
https://doi.org/10.1002/bip.22826
https://doi.org/10.1002/bip.22826
Publikováno v:
Biopolymers. 106(4)
Conformationally constrained peptides have been developed as an inhibitor for protein-protein interactions (PPIs), and we have de novo designed cyclized helix-loop-helix (cHLH) peptide with a disulfide bond consisting of 40 amino acids to generate mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d564e54d5c93b47e2b76f8466227c693
https://pubmed.ncbi.nlm.nih.gov/26917088
https://pubmed.ncbi.nlm.nih.gov/26917088
Autor:
Yasuo Miura, Takashi Uchiyama, Toshio Nishihara, Terutoshi Hishita, Chisato Mizutani, Satoshi Ichiyama, Kaoru Tohyama, Yumi Tohyama
Publikováno v:
International Journal of Hematology. 78:233-240
Expression of the Bcr-Abl oncoprotein alters various aspects of hematopoietic cells. We investigated the effects of a Bcr-Abl tyrosine kinase inhibitor, imatinib mesylate, on the proliferation, adhesive properties, and morphology of a Bcr-Abl-transfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b055a7cdc2e2b1f0dbf90b1cdb083f7
https://doi.org/10.1007/bf02983800
https://doi.org/10.1007/bf02983800
Autor:
Chisato Mizutani, Toshio Nishihara, Shigeru Yanagi, Satoshi Ichiyama, Yasuo Miura, Takashi Uchiyama, Hirohei Yamamura, Yumi Tohyama, Kaoru Tohyama, Terutoshi Hishita
Publikováno v:
Biochemical and Biophysical Research Communications. 288:80-86
The effect of adhesion via CD43 (leukosialin, sialophorin) on cell proliferation and phosphorylation signaling were examined in a growth factor-dependent hematopoietic progenitor cell line, TF-1. TF-1 cells promptly resulted in death after withdrawal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55824eb63a138150038ba370f47d82e9
https://doi.org/10.1006/bbrc.2001.5729
https://doi.org/10.1006/bbrc.2001.5729
Autor:
Satoshi Ichiyama, Yasuo Miura, Takashi Uchiyama, Kaoru Tohyama, Toshio Nishihara, Chisato Mizutani, Yumi Tohyama, Terutoshi Hishita, Hirohei Yamamura
Publikováno v:
Biochemical and biophysical research communications. 297(3)
A human megakaryoblastic cell line, CMK, was treated with 12-o-tetradecanoylphorbol-13-acetate (TPA) for differentiation–induction. We examined TPA-induced activation of the MEK1-ERK1/2 pathway in the 100,000g Triton X-insoluble fraction of CMK cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0dc08b9f812754a7ae2fe7ac3483897
https://pubmed.ncbi.nlm.nih.gov/12270146
https://pubmed.ncbi.nlm.nih.gov/12270146
Autor:
Yasunori Kawachi, Kazumasa Hikiji, Toshio Nishihara, Ayako Watanabe, Tatsumi Uchida, Kojun Setsu
Publikováno v:
Cancer genetics and cytogenetics. 89(1)
We describe a 66-year-old man who developed T-cell acute lymphoblastic leukemia (ALL) with a sole clonal chromosomal abnormality of 47,XY,+Y. Leukemic cells were positive for CD2, CD7, terminal deoxynucleotidyl transferase and cytoplasmic CD3. T-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33221e67c32ec06fee0e42d076de7163
https://pubmed.ncbi.nlm.nih.gov/8689620
https://pubmed.ncbi.nlm.nih.gov/8689620
Autor:
Kojun Setsu, Toshio Nishihara, Tatsumi Uchida, Naohito Indo, Masaharu Mori, Kimiko Ishikawa, Yukihiro Sakamoto, Yasunori Kawachi, Ayako Watanabe
Publikováno v:
Clinical therapeutics. 17(1)
A 93-year-old patient with hypoplastic acute monocytic leukemia (AMoL) achieved a complete remission after macrophage colony-stimulating factor (M-CSF) therapy. Initially, the patient was treated with a low dose of cytarabine, but this treatment prov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ea71429abc4341b8f31986744fc167
https://pubmed.ncbi.nlm.nih.gov/7758063
https://pubmed.ncbi.nlm.nih.gov/7758063
Publikováno v:
Journal of the Society of Mechanical Engineers. 92:1072-1077
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8ae4532beed87fa7fc180d8605f58ab
https://doi.org/10.1299/jsmemag.92.853_1072
https://doi.org/10.1299/jsmemag.92.853_1072
Publikováno v:
Transactions of the Japan Society of Mechanical Engineers. 13:119-124
X線應力測定に關する現在までの研究によつて,降伏點以下では鑄鐵,鋼,輕合金において機械的應力値とX線應力測定値とは極めてよく一致することが確かめられている.一旦降伏點を越して
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9f22410700dc60ce8a05cb85933f668
https://doi.org/10.1299/kikai1938.13.45_119
https://doi.org/10.1299/kikai1938.13.45_119