Zobrazeno 1 - 10
of 529
pro vyhledávání: '"Toshio, Miyata"'
Autor:
Cheng Qian, Nobuaki Ito, Kunikazu Tsuji, Shingo Sato, Katsushi Kikuchi, Toshitaka Yoshii, Toshio Miyata, Yoshinori Asou
Publikováno v:
FEBS Open Bio, Vol 14, Iss 2, Pp 290-299 (2024)
Congenital fibroblast growth factor 23 (FGF23)‐related hypophosphatemic rickets/osteomalacia is a rare bone metabolism disorder characterized by hypophosphatemia and caused by genetic abnormalities that result in excessive secretion of FGF23. Hyp m
Externí odkaz:
https://doaj.org/article/7550630872384916ae5af72381773c6c
Autor:
Toyohiro Hirai, Koichiro Asano, Isao Ito, Yasunari Miyazaki, Hisatoshi Sugiura, Mehmet Agirbasli, Seiichi Kobayashi, Makoto Kobayashi, Daishi Shimada, Ichiro Natsume, Tsutomu Kawasaki, Takehiko Ohba, Sakurako Tajiri, Fumio Sakamaki, Masamichi Mineshita, Takahisa Takihara, Kiyoshi Sekiya, Keisuke Tomii, Hiromi Tomioka, Hideo Kita, Yasuo Nishizaka, Motonari Fukui, Toshio Miyata, Hideo Harigae
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract An inhibitor of plasminogen activator inhibitor (PAI)-1, TM5614, inhibited thrombosis, inflammation, and fibrosis in several experimental mouse models. To evaluate the efficacy and safety of TM5614 in human COVID-19 pneumonia, phase IIa and
Externí odkaz:
https://doaj.org/article/b83f4be3727744ab9c975e8add942cdc
Autor:
Abd Aziz Ibrahim, Taku Fujimura, Tomoko Uno, Tomoya Terada, Ken-ichi Hirano, Hiroyuki Hosokawa, Akio Ohta, Toshio Miyata, Kiyoshi Ando, Takashi Yahata
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundIncreased levels of plasminogen activator inhibitor-1 (PAI-1) in tumors have been found to correlate with poor clinical outcomes in patients with cancer. Although abundant data support the involvement of PAI-1 in cancer progression, whether
Externí odkaz:
https://doaj.org/article/d02edfa23ac84b4a99017fbbb5525d16
Autor:
Naoto Takahashi, Yoshihiro Kameoka, Makoto Onizuka, Yasushi Onishi, Fumiaki Takahashi, Takashi Dan, Toshio Miyata, Kiyoshi Ando, Hideo Harigae
Publikováno v:
Cancer Medicine, Vol 12, Iss 4, Pp 4250-4258 (2023)
Abstract Background We recently showed that pharmacological inhibition of plasminogen activator inhibitor‐1 (PAI‐1) activity, based on TM5614, increases cell motility and induces the detachment of hematopoietic stem cells from their niches. In th
Externí odkaz:
https://doaj.org/article/9665caca70824480918b2668003eb134
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 35, Iss , Pp 100970- (2023)
Phenylketonuria is an inborn error of phenylalanine metabolism caused by a phenylalanine hydroxylase deficiency. To prevent the occurrence of neurological symptoms and maternal complications resulting from phenylketonuria, patients must adhere to a s
Externí odkaz:
https://doaj.org/article/8d6f473e20fe41c59157c1350680937f
Autor:
Nordin M.J. Hanssen, Chris Tikellis, Raelene J. Pickering, Dragana Dragoljevic, Man Kit Sam Lee, Tomasz Block, Jean LJM Scheijen, Kristiaan Wouters, Toshio Miyata, Mark E. Cooper, Andrew J. Murphy, Merlin C. Thomas, Casper G. Schalkwijk
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 158, Iss , Pp 114211- (2023)
Methylglyoxal (MGO) is a reactive glucose metabolite linked to diabetic cardiovascular disease (CVD). MGO levels surge during intermittent hyperglycemia. We hypothesize that these MGO spikes contribute to atherosclerosis, and that pyridoxamine as a M
Externí odkaz:
https://doaj.org/article/780490df861446fbb2b17dfaf51ca12a
Autor:
Joshua A. Levine, Carlota Oleaga, Mesut Eren, Ansel P. Amaral, Meng Shang, Elizabeth Lux, Sadiya S. Khan, Sanjiv J. Shah, Yasuhiro Omura, Nathalie Pamir, Joshua Hay, Grant Barish, Toshio Miyata, Hagai Tavori, Sergio Fazio, Douglas E. Vaughan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Plasminogen activator inhibitor 1 (PAI-1) is a functional biomarker of the metabolic syndrome. Previous studies have demonstrated that PAI-1 is a mechanistic contributor to several elements of the syndrome, including obesity, hypertension an
Externí odkaz:
https://doaj.org/article/70f544abac804254b08f94ba760c8b5e
Autor:
Ibrahim, Abd Aziz, Taku Fujimura, Tomoko Uno, Tomoya Terada, Ken-ichi Hirano, Hiroyuki Hosokawa, Akio Ohta, Toshio Miyata, Kiyoshi Ando, Takashi Yahata
Publikováno v:
Frontiers in Immunology; 2024, p01-16, 16p
Autor:
Mio Yamaguchi, Tomoaki Sasaki, Kodai Uemura, Yuichiro Tajima, Sho Kato, Kiyoshi Takagi, Yuto Yamazaki, Ryoko Saito-Koyama, Chihiro Inoue, Kurara Kawaguchi, Tomoya Soma, Toshio Miyata, Takashi Suzuki
Publikováno v:
Journal of Pathology Informatics, Vol 13, Iss , Pp 100147- (2022)
Background: A diagnosis with histological classification by pathologists is very important for appropriate treatments to improve the prognosis of patients with breast cancer. However, the number of pathologists is limited, and assisting the pathologi
Externí odkaz:
https://doaj.org/article/eb4e0f6472ee4678b4965963c69226f6
Autor:
Jin Imai, Takashi Yahata, Hitoshi Ichikawa, Abd Aziz Ibrahim, Masaki Yazawa, Hideaki Sumiyoshi, Yutaka Inagaki, Masashi Matsushima, Takayoshi Suzuki, Tetsuya Mine, Kiyoshi Ando, Toshio Miyata, Katsuto Hozumi
Publikováno v:
Intestinal Research, Vol 18, Iss 2, Pp 219-228 (2020)
Background/Aims Intestinal fibrosis is a major complication of Crohn’s disease (CD). The profibrotic protein transforming growth factor-β (TGF-β) has been considered to be critical for the induction of the fibrotic program. TGF-β has the ability
Externí odkaz:
https://doaj.org/article/990179d6f86f4070a843a3b057abdb35