Výsledky vyhledávání - "Toshio, Ariyasu"

Akademický článek

Inflammatory M1-like macrophages polarized by NK-4 undergo enhanced phenotypic switching to an anti-inflammatory M2-like phenotype upon co-culture with apoptotic cells

Autor: Keizo Kohno, Satomi Koya-Miyata, Akira Harashima, Takahiko Tsukuda, Masataka Katakami, Toshio Ariyasu, Shimpei Ushio, Kanso Iwaki

Publikováno v: Journal of Inflammation, Vol 18, Iss 1, Pp 1-14 (2021)

Abstract Background NK-4 has been used to promote wound healing since the early-1950s; however, the mechanism of action of NK-4 is unknown. In this study, we examined whether NK-4 exerts a regulatory effect on macrophages, which play multiple roles d

Externí odkaz: https://doaj.org/article/8c272b6312f8464294ccaa27bcdb6367

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Akademický článek

Trehalose itself plays a critical role on lipid metabolism: Trehalose increases jejunum cytoplasmic lipid droplets which negatively correlated with mesenteric adipocyte size in both HFD-fed trehalase KO and WT mice

Autor: Chikako Arai, Aki Suyama, Shigeyuki Arai, Norie Arai, Chiyo Yoshizane, Satomi Koya-Miyata, Akiko Mizote, Shin Endo, Toshio Ariyasu, Hitoshi Mitsuzumi, Shimpei Ushio

Publikováno v: Nutrition & Metabolism, Vol 17, Iss 1, Pp 1-12 (2020)

Abstract Background Trehalose is a functional disaccharide that has anti-metabolic activities such as suppression of adipocyte hypertrophy in mice and alleviation of impaired glucose tolerance in humans. Trehalase hydrolyzes trehalose in the small in

Externí odkaz: https://doaj.org/article/1c4067d1957f45ce8aa1a82f05ff8ef0

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Akademický článek

Continuous intake of Trehalose induces white adipose tissue Browning and Enhances energy metabolism

Autor: Chikako Arai, Norie Arai, Shigeyuki Arai, Chiyo Yoshizane, Satomi Miyata, Akiko Mizote, Aki Suyama, Shin Endo, Toshio Ariyasu, Hitoshi Mitsuzumi, Shimpei Ushio

Publikováno v: Nutrition & Metabolism, Vol 16, Iss 1, Pp 1-13 (2019)

Abstract Background Trehalose is well known as a functional disaccharide with anti-metabolic activities such as suppression of adipocyte hypertrophy in mice and alleviation of impaired glucose tolerance in humans. Recently, a new type of adipocyte be

Externí odkaz: https://doaj.org/article/1f2c094acd85484ab1d35b2476627716

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Akademický článek

NK-4 exerts selective regulatory effects on the activation and function of allergy-related Th2 cells.

Autor: Keizo Kohno, Satomi Koya-Miyata, Akira Harashima, Toshio Ariyasu, Shimpei Ushio

Publikováno v: PLoS ONE, Vol 13, Iss 6, p e0199666 (2018)

NK-4 is the main component of the antiallergic drug Lumin, which has been in popular usage since the early 1950s. In this study, we examined whether NK-4 exerts a regulatory effect on the activation and effector function of Th2 cells. NK-4 inhibited

Externí odkaz: https://doaj.org/article/bb6fac01f2284b748e8747f786b01f7b

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Trehalose alleviates oxidative stress-mediated liver injury and Mallory-Denk body formation via activating autophagy in mice

Autor: Toshio Ariyasu, Masaru Harada, Katsuhiko Hino, Akira Kawashima, Yuka Katsuki, Hitomi Mihara, Miyuki Sato-Morita, Ryoko Baba, Yuichi Honma

Publikováno v: Medical Molecular Morphology. 54:41-51

Autophagy is a degradation pathway for long-lived cytoplasmic proteins or damaged organelles and also for many aggregate-prone and disease-causing proteins. Endoplasmic reticulum (ER) stress and oxidative stress are associated with the pathophysiolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fe3c7d8af8c5b5f2a4ca4c8a7d1ed7
https://doi.org/10.1007/s00795-020-00258-2

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Autor: Hitoshi Mitsuzumi, Norie Arai, Shigeyuki Arai, Akiko Mizote, Shin Endo, Chiyo Yoshizane, Shimpei Ushio, Satomi Koya-Miyata, Chikako Arai, Aki Suyama, Toshio Ariyasu

Publikováno v: Nutrition & Metabolism, Vol 17, Iss 1, Pp 1-12 (2020)
Nutrition & Metabolism

Background Trehalose is a functional disaccharide that has anti-metabolic activities such as suppression of adipocyte hypertrophy in mice and alleviation of impaired glucose tolerance in humans. Trehalase hydrolyzes trehalose in the small intestine i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe64de72ab9ef067cddb5eb5e65d3ce
http://link.springer.com/article/10.1186/s12986-020-00443-1

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[Inhibition of TRPV2 Channel Activation by NK-4, a Cryptocyanine Dye]

Autor: Satomi Koya-Miyata, Keizo Kohno, Takashi Morimoto, Akira Harashima, Yuko Iwata, Toshio Ariyasu

Publikováno v: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 142(5)

Transient receptor potential vanilloid 2 (TRPV2) channels are expressed and play functional roles in various immune cells. Physical stimuli leading to TRPV2 activation causes mast cell degranulation. Besides their roles in immune cells, it has been s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dffcd0b5a4b4adb0b55ee0a4f4680cee
https://pubmed.ncbi.nlm.nih.gov/35228454

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Continuous intake of Trehalose induces white adipose tissue Browning and Enhances energy metabolism

Autor: Chiyo Yoshizane, Satomi Miyata, Akiko Mizote, Norie Arai, Toshio Ariyasu, Aki Suyama, Shin Endo, Shigeyuki Arai, Chikako Arai, Shimpei Ushio, Hitoshi Mitsuzumi

Publikováno v: Nutrition & Metabolism, Vol 16, Iss 1, Pp 1-13 (2019)
Nutrition & Metabolism

Background Trehalose is well known as a functional disaccharide with anti-metabolic activities such as suppression of adipocyte hypertrophy in mice and alleviation of impaired glucose tolerance in humans. Recently, a new type of adipocyte beige cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f3aebaca043972964dc4cc5195f8ae
http://link.springer.com/article/10.1186/s12986-019-0373-4

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Adenosine N1-Oxide Exerts Anti-inflammatory Effects through the PI3K/Akt/GSK-3β Signaling Pathway and Promotes Osteogenic and Adipocyte Differentiation

Autor: Norie Arai, Akira Harashima, Shimpei Ushio, Emiko Ohashi, Toshio Ariyasu, Keizo Kohno

Publikováno v: Biological and Pharmaceutical Bulletin. 42:968-976

Previously, we reported that adenosine N1-oxide (ANO), which is found in royal jelly, inhibited the secretion of inflammatory mediators by activated macrophages and reduced lethality in lipopolysaccharide (LPS)-induced endotoxin shock. Here, we exami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4656bd89e35234baeee5829b5afbb04c
https://doi.org/10.1248/bpb.b18-00988

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Ingredients such as trehalose and hesperidin taken as supplements or foods reverse alterations in human T cells, reducing asbestos exposure-induced antitumor immunity

Autor: Yasuda Akiko, Nagisa Sada, Yurika Shimizu, Suni Lee, Toshio Ariyasu, Satomi Miyata, Takemi Otsuki, Shin Endo, Bandaru Srinivas, Shoko Yamamoto, Yasumitsu Nishimura, Tsunetaka Ohta, Naoko Kumagai-Τakei, Akira Harashima, Tatsuo Ito

Publikováno v: International Journal of Oncology

Exposure of human immune cells to asbestos causes a reduction in antitumor immunity. The present study aimed to investigate the recovery of reduced antitumor immunity by several ingredients taken as supplements or foods, including trehalose (Treh) an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8f6f7b612b6727a5457647cc9ab05f
https://doi.org/10.3892/ijo.2021.5182

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