Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Toshinori Takagi"'
Autor:
Yasunori Yoshida, Yuki Takeda, Kenichi Yamahara, Hanae Yamamoto, Toshinori Takagi, Yoji Kuramoto, Akiko Nakano-Doi, Takayuki Nakagomi, Toshihiro Soma, Tomohiro Matsuyama, Nobutaka Doe, Shinichi Yoshimura
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Umbilical cord blood (UCB) transplantation shows proangiogenic effects and contributes to symptom amelioration in animal models of cerebral infarction. However, the effect of specific cell types within a heterogeneous UCB population are stil
Externí odkaz:
https://doaj.org/article/3c1c212222c54d4cb8c75b2fef71e0f8
Autor:
Yoji Kuramoto, Mitsugu Fujita, Toshinori Takagi, Yuki Takeda, Nobutaka Doe, Kenichi Yamahara, Shinichi Yoshimura
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-19 (2022)
Abstract Background Intracerebral hemorrhage (ICH) is a significant cause of death and disabilities. Recently, cell therapies using mesenchymal stem cells have been shown to improve ICH-induced neurobehavioral deficits. Based on these findings, we de
Externí odkaz:
https://doaj.org/article/01eea14a7c55467e838e64c07f37b355
Autor:
Yasunori Yoshida, Toshinori Takagi, Yoji Kuramoto, Kotaro Tatebayashi, Manabu Shirakawa, Kenichi Yamahara, Nobutaka Doe, Shinichi Yoshimura
Publikováno v:
Cell Transplantation, Vol 30 (2021)
Neuro-inflammation plays a key role in the pathophysiology of brain infarction. Cell therapy offers a novel therapeutic option due to its effect on immunomodulatory effects. Amniotic stem cells, in particular, show promise owing to their low immunoge
Externí odkaz:
https://doaj.org/article/2eeef86ec1e243f79c8bde1b1a1ac14a
Autor:
Toshinori Takagi, Hideaki Hara
Publikováno v:
Journal of Pharmacological Sciences, Vol 131, Iss 3, Pp 155-161 (2016)
Cilostazol is a phosphodiesterase-3 inhibitor and is known to have pleiotropic effects including antiplatelet and vasodilatation effects and protective effects on endothelial cells. Cilostazol also reportedly reduced stroke recurrence, poststroke int
Externí odkaz:
https://doaj.org/article/b128474eb8684c78b14d1563679681b5
Autor:
Takahiko Imai, Toshinori Takagi, Akira Kitashoji, Keita Yamauchi, Masamitsu Shimazawa, Hideaki Hara
Publikováno v:
Neurobiology of Disease, Vol 89, Iss , Pp 136-146 (2016)
Background and purpose: Oxidative stress has been reported to be a main cause of neuronal cell death in ischemia reperfusion injury (IRI). Nuclear factor-erythroid 2-related factor 2 (Nrf2) is an important factor involved in anti-oxidative responses.
Externí odkaz:
https://doaj.org/article/1a1b3e5443e14629ad25f868f001c677
Autor:
Yasue Tanaka, Nami Nakagomi, Nobutaka Doe, Akiko Nakano-Doi, Toshinori Sawano, Toshinori Takagi, Tomohiro Matsuyama, Shinichi Yoshimura, Takayuki Nakagomi
Publikováno v:
Cells, Vol 9, Iss 6, p 1374 (2020)
Ischemic stroke is a critical disease caused by cerebral artery occlusion in the central nervous system (CNS). Recent therapeutic advances, such as neuroendovascular intervention and thrombolytic therapy, have allowed recanalization of occluded brain
Externí odkaz:
https://doaj.org/article/71e5269e4fa64e968d36815686509990
Autor:
Keisuke Mishiro, Takahiko Imai, Sou Sugitani, Akira Kitashoji, Yukiya Suzuki, Toshinori Takagi, Huayue Chen, Yasunori Oumi, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103818 (2014)
Diabetes is a crucial risk factor for stroke and is associated with increased frequency and poor prognosis. Although endothelial dysfunction is a known contributor of stroke, the underlying mechanisms have not been elucidated. The aim of this study w
Externí odkaz:
https://doaj.org/article/1b6f2116912c4912a90f512228bcacf5
Autor:
Yoji Kuramoto, Toshinori Takagi, Yuki Takeda, Saujanya Rajbhandari, Yasunori Yoshida, Takayuki Nakagomi, Shinichi Yoshimura
Publikováno v:
Stem Cells and Development. 31:555-568
We showed that injury-induced multipotent stem cells (iSCs) emerge in the brain after stroke. These brain-derived iSCs (B-iSCs) can differentiate into various lineages, including neurons. This study aimed to determine whether similar stem cells can b
Autor:
Takayuki Nakagomi, Akiko Nakano-Doi, Shuji Kubo, Toshinori Sawano, Yoji Kuramoto, Kenichi Yamahara, Tomohiro Matsuyama, Toshinori Takagi, Nobutaka Doe, Shinichi Yoshimura
Publikováno v:
Stem Cells Translational Medicine.
We recently demonstrated that injury/ischemia-induced multipotent stem cells (iSCs) develop within post-stroke human brains. Because iSCs are stem cells induced under pathological conditions, such as ischemic stroke, the use of human brain-derived iS
Autor:
Yoshiaki Maruyama, Akira Sakurai, Shinichi Noda, Yasuhiro Fujiwara, Narumi Okura, Toshinori Takagi, Junichi Asano, Futaba Honda
Publikováno v:
The Oncologist.
In June 2021, the Ministry of Health, Labor and Welfare approved Delytact Injection as a regenerative medical product for oncolytic virus therapy. The active substance of Delytact Injection is teserpaturev, a genetically engineered herpes simplex vir